Results 141 to 150 of about 9,496,868 (341)

Subjective memory impairment: No suitable criteria for case‐finding of dementia in primary care

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2015
Introduction Subjective memory impairment (SMI) might be used for the case‐finding of dementia. Present analyses aim to determine the diagnostic value and the predictive ability of SMI and related worries for the discrimination of patients screened ...
Tilly Eichler, Jochen René Thyrian, Johannes Hertel, Diana Wucherer, Bernhard Michalowsky, Katinka Reiner, Adina Dreier, Ingo Kilimann, Stefan Teipel, Wolfgang Hoffmann   +9 more
doaj   +1 more source

Early Language Impairment as an Integral Part of the Cognitive Phenotype in Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Huntington's disease (HD) speech/language disorders have typically been attributed to motor and executive impairment due to striatal dysfunction. In‐depth study of linguistic skills and the role of extrastriatal structures in HD is scarce.
Arnau Puig‐Davi, Carla Franch‐Marti, Iñigo Ruiz‐Barrio, Frederic Sampedro, Jesus Perez‐Perez, Jordi A. Matias‐Guiu, Fernando Cuetos, Gonzalo Olmedo‐Saura, Laura Perez‐Carasol, Andrea Horta‐Barba, Ignacio Aracil‐Bolaños, Javier Pagonabarraga, Jaime Kulisevsky, Saul Martinez‐Horta   +13 more
wiley   +1 more source

Neurodegeneration in tauopathies and synucleinopathies [PDF]

, 2016
While increasing life expectancy is a major achievement, the global aging of societies raises a number of medical issues, such as the development of age-related disorders, including neurodegenerative diseases.
Foguem, Clovis, Kamsu-Foguem, Bernard
core   +3 more sources

A Novel CHMP2B Splicing Variant in Atypical Presentation of Familial Frontotemporal Lobar Degeneration

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT C‐truncating variants in the charged multivesicular body protein 2B (CHMP2B) gene are a rare cause of frontotemporal lobar degeneration (FTLD), previously identified only in Denmark, Belgium, and China. We report a novel CHMP2B splice‐site variant (c.35‐1G>A) associated with familial FTLD in Spain. The cases were two monozygotic male twins who
Sara Rubio‐Guerra, Sara Bernal, David Almenta, Josefina Pérez‐Blanco, Valle Camacho, Isabel Sala, Mª Belén Sánchez‐Saudinós, Jesús García Castro, Judit Selma‐González, Miguel Ángel Santos‐Santos, Álvaro Carbayo, Janina Turon‐Sans, Ricard Rojas‐Garcia, Daniel Alcolea, Juan Fortea, Alberto Lleó, Oriol Dols‐Icardo, Ignacio Illán‐Gala   +17 more
wiley   +1 more source

Striatal dopamine neurotransmission is altered in age- and region-specific manner in a Parkinson’s disease transgenic mouse

Scientific Reports
Dopamine (DA) plays a critical role in striatal motor control. The drop in DA level within the dorsal striatum is directly associated with the appearance of motor symptoms in Parkinson’s disease (PD).
Jose Medina-Luque, Patrick Piechocinski, Paul Feyen, Carmelo Sgobio, Jochen Herms   +4 more
doaj   +1 more source

Brain tyrosinase overexpression implicates age-dependent neuromelanin production in Parkinson’s disease pathogenesis

Nature Communications, 2019
It is unclear if neuromelanin plays a role in Parkinson’s disease pathogenesis since common laboratory animals lack this pigment. Authors show here that overexpression of human tyrosinase in the substantia nigra of rats resulted in an age-dependent ...
Iria Carballo-Carbajal, Ariadna Laguna, Jordi Romero-Giménez, Thais Cuadros, Jordi Bové, Marta Martinez-Vicente, Annabelle Parent, Marta Gonzalez-Sepulveda, Núria Peñuelas, Albert Torra, Beatriz Rodríguez-Galván, Andrea Ballabio, Takafumi Hasegawa, Analía Bortolozzi, Ellen Gelpi, Miquel Vila   +15 more
doaj   +1 more source

Neural Stem Cell Transplantation for Neurodegenerative Diseases

International Journal of Molecular Sciences, 2020
Neurodegenerative diseases are disabling and fatal neurological disorders that currently lack effective treatment. Neural stem cell (NSC) transplantation has been studied as a potential therapeutic approach and appears to exert a beneficial effect ...
Roberta De Gioia, Fabio Biella, Gaia Citterio, F. Rizzo, E. Abati, M. Nizzardo, N. Bresolin, G. Comi, S. Corti   +8 more
semanticscholar   +1 more source

Molecular dynamics studies on the NMR and X-ray structures of rabbit prion protein wild-type and mutants

, 2013
Prion diseases are invariably fatal and highly infectious neurodegenerative diseases that affect a wide variety of mammalian species such as sheep, goats, mice, humans, chimpanzees, hamsters, cattle, elks, deer, minks, cats, chicken, pigs, turtles, etc ...
Barlow, Baron, Barry, Barry, Barry, Bastian, Bencsik, Bendheim, Bett, Biswas, Bitel, Bjorndahl, Bockman, Bode, Brun, Caughey, Chianini, Cho, Chou, Chou, Chou, Chou, Chou, Chou, Chou, Christen, Christen, Christen, Christen, Cong, Courageot, Damberger, Di Martino, Dong, Dupiereux, Farquhar, Fernandez-Funez, Fernandez-Funez, Fernandez-Funez, Fernández-Borges, Friedman-Levi, Gabizon, Gabizon, Gao, Garrec, Garssen, Gerber, Gilch, Golanska, Gossert, Groschup, Groschup, Groschup, Guiroy, Handisurya, Hanoux, Hashimoto, Hay, Huang, Ikegami, Ishiguro, Ishikawa, Jackman, Jiapu Zhang, Julien, Kabsch, Kascsak, Kascsak, Kelker, Khan, Kim, Kirby, Kirkwood, Kitamoto, Kocisko, Komar, Korth, Laude, Lawson, Li, Li, Loftus, Lopez, Lührs, Ma, Madec, Mays, Meli, Merz, Miller, Nisbet, Oboznaya, Onodera, Polymenidou, Pérez, Riek, Robakis, Roberts, Rossetti, Sachsamanoglou, Sakudo, Schmerr, Senator, Shin, Shinagawa, Sigurdson, Sigurdson, Sigurdson, Stanker, Sweeting, Takahashi, Takahashi, Takekida, Tang, Timmes, Vidal, Vilette, Vol'pina, Vorberg, Wade, Wang, Wen, Wen, Wiley, Xi, Xiao, Yokoyama, Yokoyama, Yost, Yuanli Zhang, Zahn, Zhang, Zhang, Zhang, Zhang, Zhang, Zhao, Zhou, Zhou, Zhou, Zhou, Zhou, Zocche Soprana   +142 more
core   +1 more source

Neurodegenerative Diseases – Is Metabolic Deficiency the Root Cause?

Frontiers in Neuroscience, 2020
Neurodegenerative diseases, including Alzheimer, Parkinson, Huntington, and amyotrophic lateral sclerosis, are a prominent class of neurological diseases currently without a cure. They are characterized by an inexorable loss of a specific type of neurons.
V. R. Muddapu, S. Dharshini, V. Chakravarthy, M. M. Gromiha   +3 more
semanticscholar   +1 more source

AAD-2004, a potent spin trapping molecule and microsomal prostaglandin E synthase-1 inhibitor, shows safety and efficacy in a mouse model of ALS [PDF]

, 2010
While free radicals and inflammation constitute major routes of neuronal injury occurring in neurodegenerative diseases, neither antioxidants nor nonsteroidal anti-inflammatory drugs (NSAIDs) have shown significant efficacy in human clinical trials.
Bok Yun, Byoung Gwag, Doo Im, Jae Lee, Jin Lee, Jin Shin, Joe Springer, Soo Byun, Sun Park, Sun Son, Woong Cho, Yong Lee, Young Lee   +12 more
core   +1 more source