Results 221 to 230 of about 9,572,367 (390)

The Fluorescent Congo Red Derivative, (Trans, Trans)−1-Bromo-2,5-Bis-(3-Hydroxycarbonyl-4-Hydroxy)Styrylbenzene (BSB), Labels Diverse β-Pleated Sheet Structures in Postmortem Human Neurodegenerative Disease Brains [PDF]

, 2001
Marie L. Schmidt, Theresa Schuck, Shelly Sheridan, Mei‐Ping Kung, Hank F. Kung, Zhi‐Ping Zhuang, Catherine Bergeron, Jacque S. Lamarche, Daniel Skovronsky, Benoit I. Giasson, Virginia M.‐Y. Lee, John Q. Trojanowski   +11 more
openalex   +1 more source

Aging on Chip: Harnessing the Potential of Microfluidic Technologies in Aging and Rejuvenation Research

Advanced Healthcare Materials, EarlyView.
This review highlights recent advances in microfluidic technologies for modeling human aging and age‐related diseases. It explores how organ‐on‐chip platforms improve physiological relevance, enable rejuvenation strategies, facilitate drug screening, detect senescent cells, and identify biomarkers.
Limor Zwi‐Dantsis, Vignesh Jayarajan, George M. Church, Roger D. Kamm, João Pedro de Magalhães, Emad Moeendarbary   +5 more
wiley   +1 more source

Attenuated Neurodegenerative Disease Phenotype in Tau Transgenic Mouse Lacking Neurofilaments [PDF]

, 2001
Takeshi Ishihara, Makoto Higuchi, Bin Zhang, Yasumasa Yoshiyama, Ming Hong, John Q. Trojanowski, Virginia M.-Y. Lee   +6 more
openalex   +1 more source

Membrane Fusion‐Inspired Nanomaterials: Emerging Strategies for Infectious Disease and Cancer Diagnostics

Advanced Healthcare Materials, EarlyView.
Membrane fusion‐inspired nanomaterials offer transformative potential in diagnostics by mimicking natural fusion processes to achieve highly sensitive and specific detection of disease biomarkers. This review highlights recent advancements in nanomaterial functionalization strategies, signal amplification systems, and stimuli‐responsive fusion designs,
Sojeong Lee, Khulan Nyamzaya, Jueun Han, Yejin Song, Jihee Lee, Jung Hyun Jo, Seungmin Bang, Eun‐Kyung Lim, Seungjoo Haam, Eunjung Kim   +9 more
wiley   +1 more source

Blood-based quantification of Aβ oligomers indicates impaired clearance from brain in ApoE ε4 positive subjects

Communications Medicine
Background Quantification of Amyloid beta (Aβ) oligomers in plasma enables early diagnosis of Alzheimer’s Disease (AD) and improves our understanding of underlying pathologies.
Lara Blömeke, Fabian Rehn, Marlene Pils, Victoria Kraemer-Schulien, Anneliese Cousin, Janine Kutzsche, Tuyen Bujnicki, Silka D. Freiesleben, Luisa-Sophie Schneider, Lukas Preis, Josef Priller, Eike J. Spruth, Slawek Altenstein, Anja Schneider, Klaus Fliessbach, Jens Wiltfang, Niels Hansen, Ayda Rostamzadeh, Emrah Düzel, Wenzel Glanz, Enise I. Incesoy, Katharina Buerger, Daniel Janowitz, Michael Ewers, Robert Perneczky, Boris-Stephan Rauchmann, Stefan Teipel, Ingo Kilimann, Christoph Laske, Matthias H. Munk, Annika Spottke, Nina Roy, Michael T. Heneka, Frederic Brosseron, Michael Wagner, Sandra Roeske, Alfredo Ramirez, Matthias Schmid, Frank Jessen, Oliver Bannach, Oliver Peters, Dieter Willbold   +41 more
doaj   +1 more source

Cognitive Deficits Associated With a Recently Reported Familial Neurodegenerative Disease [PDF]

, 2001
Charles B. Bradshaw, Richard L. Davis, Antony E. Shrimpton, P D Holohan, Cornelia B. Rea, David Fieglin, Paul F. Kent, George H. Collins   +7 more
openalex   +1 more source

Gene-based therapies for neurodegenerative diseases

Nature Neuroscience, 2021
Jichao Sun, Subhojit Roy
semanticscholar   +1 more source

Molecular Mechanisms of Extracellular Vesicle Biogenesis and Their Impact on the Design of Custom EVs

Advanced Healthcare Materials, EarlyView.
Extracellular vesicles (EVs) are pivotal mediators of intercellular communication and disease, yet the fundamental mechanisms controlling their biogenesis and cargo selection remain unclear. This limitation hinders their diagnostic utility and therapeutic development.
Luís Carvalho Ferraz, Paulo Pereira, João Vasco Ferreira   +2 more
wiley   +1 more source

Application of IVDr NMR spectroscopy to stratify Parkinson’s disease with absolute quantitation of blood serum metabolites and lipoproteins

Scientific Reports
The challenge of early detection and stratification in Parkinson’s disease (PD) is urgent due to the current emergence of mechanism-based disease-modifying treatments.
Georgy Berezhnoy, Gyuntae Bae, Leonie Wüst, Claudia Schulte, Claire Cannet, Isabel Wurster, Milan Zimmermann, Alexander Jäck, Eike Jakob Spruth, Julian Hellmann-Regen, Sandra Roeske, Dominik Pürner, Wenzel Glanz, Fabian Maass, Felix Hufschmidt, Ingo Kilimann, Elisabeth Dinter, Okka Kimmich, Anna Gamez, Johannes Levin, Josef Priller, Oliver Peters, Michael Wagner, Alexander Storch, Paul Lingor, Emrah Düzel, Christoph van Riesen, Ullrich Wüllner, Stefan Teipel, Björn Falkenburger, Mathias Bähr, Inga Zerr, Gabor C. Petzold, Annika Spottke, Patricia Rizzu, Frederic Brosseron, Hartmut Schäfer, Thomas Gasser, Christoph Trautwein   +38 more
doaj   +1 more source

Gene therapy for neurodegenerative diseases: fact or fiction? [PDF]

, 2001
Janet E. Carter, Edward H. Schuchman
openalex   +1 more source