Results 231 to 240 of about 2,554,961 (312)

Polyphenols and microglial dynamics in neurodegenerative diseases: mechanistic advances and therapeutic perspectives. [PDF]

PeerJ
Liu L, Xiao H, Zhou J, Zhang M, Duan J.
europepmc   +1 more source

Label‐Free Myelin Fingerprinting: An Adult Human Post‐Mortem Brain Slice Platform via Coherent Anti‐Stokes Raman Spectroscopy

Advanced Science, EarlyView.
A serum‐free, air–liquid interface organotypic slice culture model preserves human post‐mortem corpus callosum tissue, successfully recovering from slicing trauma to reflect the donor's underlying disease state. Pairing label‐free Coherent anti‐Stokes Raman scattering (CARS) microscopy with k‐means clustering enables objective, high‐resolution ...
Kasra Roya‐Kouchaki, Jeroen P. Korterik, Femke Tjebbes, Geert J. Schenk, Herman L. Offerhaus, Antonio Luchicchi   +5 more
wiley   +1 more source

Pollutants regulate changes in pathological markers of neurodegenerative diseases: a new perspective in environmental toxicology. [PDF]

Front Toxicol
Kou X, Hu Q, Kou Y, An D.
europepmc   +1 more source

EphB1‐Mediated Transient Blood‐Brain Barrier Opening Facilitates a Ferritin‐Based Nanotherapeutic for Alzheimer's Disease

Advanced Science, EarlyView.
We constructed a brain‐targeted AFn‐DPZ nanodrug delivery system and identified EphB1 as its receptor on the blood‐brain barrier (BBB). This system facilitates drug transport across the BBB and thereby ameliorates cognitive impairment in Alzheimer's disease.
Shilin Wen, Jingjing Gao, Zhixian Wang, Qiumin Ma, Xiao‐Ling Xu, Jianer Chen   +5 more
wiley   +1 more source

Thermodynamic Frontiers in Hemoglobin-Inspired Polymer Science for Diagnosis and Modulation of Neurodegenerative Diseases. [PDF]

Cell Biochem Funct
Edrisi M, Rabiee N.
europepmc   +1 more source

Deconstruction of Human Age‐Related Cataract Capsules Defines Aging

Advanced Science, EarlyView.
We generate a comprehensive atlas of age‐related cataracts (ARC) at a single‐cell resolution, encompassing three disease states—mild cataract group (Mild), severe cortical cataract group (Severe_C), and severe nuclear cataract group (Severe_N). We find that ARC involves seven distinct lens capsule cell types, with notable differences in cellular ...
Qiaomei Tang, Ziyang Tong, Chunmei Fan, Silong Chen, Jiarui Guo, Jianghua Hu, Ke Yao, Zi Yin, Xiao Chen, Yibo Yu   +9 more
wiley   +1 more source

Targeting cellular senescence through nutritional senotherapeutics in brain aging and neurodegenerative diseases. [PDF]

Front Nutr
Salas-Venegas V, López-Diazguerrero NE, Ramírez-Carreto RJ, Konigsberg M, Chavarría A.   +4 more
europepmc   +1 more source

Coordination‐Tuned Iridium Single‐Atom Nanozymes Boost Multienzyme Activity for Colorimetric Sensing

Advanced Science, EarlyView.
Breaking the coordination symmetry of Ir single‐atom sites through asymmetric Ir–N3S1 engineering tailors interfacial electron transfer, oxygen activation, and multienzyme‐like catalytic pathways. Operando spectroscopy and theoretical modeling uncover the atomic‐level origin of activity enhancement, providing a strategy for designing multifunctional ...
Tao Li, Xinyu Zhang, Jiashan Xia, Mengyu Wu, Cong Liu, Yapei Sun, Wanjiang Zhao, Min Qian, Wei Wang, Weixia Duan, Shangcheng Xu   +10 more
wiley   +1 more source

Sex-aware causal inference assessment of the immune system in complex neurodegenerative diseases. [PDF]

Brain
Lona-Durazo F, Byrne RP, Pilon MO, Greicius MD, Dubé MP, Belloy ME, McLaughlin RL, Gagliano Taliun SA.   +7 more
europepmc   +1 more source