Results 251 to 260 of about 2,554,961 (312)

Self‐Assembly of Antigenic Peptide Nanofibrils Templates the Growth of Silica Nanoparticles for Nanovaccines

Advanced Science, EarlyView.
Antigenic peptides Aβ42 and E7 self‐assemble into nanofibrils; APTES and TEOS induce SiO2 NP formation on these fibrils to form SiO2@fibril nanovaccines, which activate BMDCs in vitro. In vivo, SiO2@Aβ42 fibril nanovaccines alleviate AD symptoms and clear Aβ42 plaques in APP/PS1 mice, and SiO2@E7 fibril nanovaccines inhibit tumor growth and promote ...
Xuecheng Yang, Min Li, Zhiying Yao, Yu Hu, Zhili Wang, Wendi Shi, Bingbing Sun   +6 more
wiley   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases. [PDF]

FEBS Lett
Halliwell B.
europepmc   +1 more source

Therapeutic Gene Editing of APOE4 in Sporadic Alzheimer's Disease via Prime Editor 7

Advanced Science, EarlyView.
Prime Editor 7‐mediated conversion of APOE4 to APOE3 alleviates Alzheimer's disease‐associated pathology in AD mouse models and patient‐derived neurons and improves cognitive performance in vivo, supporting therapeutic genome editing as a promising strategy for APOE4‐associated neurodegeneration.
Yunkyung Kim, Gaeun Lee, Saemin An, Hanseul Park, Hongwon Kim, Jisung Kim, Soi Kang, Sumin Kim, Daeyeol Kwon, Jeonghyun Park, Yerim Hwang, Seonghun Kim, Xiuwen Yuan, Jaehoon Jeong, Hamin Lee, Hui Kwon Kim, Jongpil Kim   +16 more
wiley   +1 more source

Pridopidine Mediated Sigma-1 Receptor Activation and Therapeutic Implications in Neurodegenerative Diseases. [PDF]

Neurol Int
Anwar AI, Hegazi AA, Bhuchakra HP, Nelson JR, Birdsong TL, Fontenot CJ, Zeibo M, Fazal-Ur-Rehman MM, Bieber HP, Spring CJ, Smith JL, Hachem IA, Singh T, Sawaya MF, Murnane KS, Kaye AD.   +15 more
europepmc   +1 more source

Gut Microbial Release of Ferulic Acid From Germinated Quinoa Alleviates Obesity‐Associated Cognitive Impairment by Activating Hippocampal Mitophagy Associated with PINK1/Parkin Pathway

Advanced Science, EarlyView.
Liberation of ferulic acid by gut microbial feruloyl esterase mediates cognitive enhancement of germinated quinoa (GQF) on obese mice. Ferulic acid enriched in GQF is released by gut microbes Roseburia hominis and R. intestinalis and subsequently mediates the neuroprotective effects of GQF on obesity‐induced cognitive decline by activating hippocampal ...
Yongli Lan, Wengang Zhang, Lei Wang, Shiyang Zhao, Yujie Song, Xinze Wang, Yutang Wang, Xijuan Yang, Shaobo Ma, Junlin Ge, Rui Guo, Xuebo Liu   +11 more
wiley   +1 more source

A standardized framework resolves ambiguity in motor neuron loss across neurodegenerative diseases. [PDF]

Acta Neuropathol Commun
Sowoidnich L, Norman AL, Gerstner F, Siemund JK, Buettner JM, Pagiazitis JG, Dreilich V, Pilz K, Tian D, Sumner CJ, Paradis A, Mentis GZ, Simon CM.   +12 more
europepmc   +1 more source

A Unifying Thermodynamic Model for Phase Separation and Aging of Biopolymers

Advanced Science, EarlyView.
Phase separation and aging of intrinsically disordered proteins are placed in a unifying framework. A thermodynamically consistent time‐dependent version of associating‐polymer theory shows how the processes are intricately coupled. Assuming aging to occur through interacting sites resulting from reversible conformational transitions, the model ...
Jasper J. Michels, Joana Caria, Edward A. Lemke   +2 more
wiley   +1 more source

Role of Microbial Toxins in Neurodegenerative Diseases: Insights and Future Perspectives. [PDF]

Biomolecules
Singh AA, Khan F, Song M.
europepmc   +1 more source

Editorial: Unraveling protein misfolding and innate immunity in neurodegenerative diseases. [PDF]

Front Immunol
Fang Q, Hong Y, Zhu B.
europepmc   +1 more source

Deep learning-based cortical thickness maps for diagnosis of neurodegenerative diseases: a rater study. [PDF]

Alzheimers Dement (Amst)
Riedel EO, Bongratz F, Zott B, Berberich C, Eichinger P, Yakushev I, Grimmer T, Wachinger C, Hedderich DM.   +8 more
europepmc   +1 more source