Results 271 to 280 of about 2,554,961 (312)
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Microglia in neurodegenerative disease
Nature Reviews Neurology, 2010Microglia, the resident macrophages of the CNS, are exquisitely sensitive to brain injury and disease, altering their morphology and phenotype to adopt a so-called activated state in response to pathophysiological brain insults. Morphologically activated microglia, like other tissue macrophages, exist as many different phenotypes, depending on the ...
Perry, V. Hugh +2 more
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Neuroprotection and Neurodegenerative Disease
Journal of Clinical Neuroscience, 2002This paper will focus on commonalities in the aetiology and pathology in five areas of neurological disease with illustrative examples of therapy. Possibilities of multimodal and neuroprotective therapies in human disease, employing currently available drugs and showing evidence of neuroprotective potential in animal models, are discussed.
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Neurodegenerative Diseases and Ageing
2019This chapter describes the main neuropathological features of the most common age associated neurodegenerative diseases including Alzheimer's disease, Lewy body diseases, vascular dementia and the various types of frontotemporal lobar degeneration.
Walker L +3 more
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Glycosaminoglycans in Neurodegenerative Diseases
2021Glycosaminoglycans (GAGs) are linear polysaccharides that consist of alternating disaccharides sequences of uronic acids and/or galactose hexamino sugars most of which are sulfated. GAGs are ubiquitously expressed on the cell surface, in the intracellular milieu and in the extracellular matrix of all animal cells.
Weihua, Jin +2 more
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Sleep in Neurodegenerative Diseases
Sleep Medicine Clinics, 2016Disorders of sleep are an integral part of neurodegenerative diseases and include insomnia, sleep-wake cycle disruption, excessive daytime sleepiness that may be manifested as persistent somnolence or sudden onset of sleep episodes, obstructive and central sleep apnea, rapid eye movement sleep behavior disorder, and restless legs syndrome.
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Apoptosis in Neurodegenerative Diseases
1997Publisher Summary This chapter reviews pathological features of various neurodegenerative diseases, the relevance of apoptosis in their pathogenesis, and underlying genetic abnormalities. The chapter also describes proposed mechanisms for Alzheimer's disease (AD) neurodegeneration.
I, Nishimoto +3 more
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Meditation and neurodegenerative diseases
Annals of the New York Academy of Sciences, 2013Neurodegenerative diseases pose a significant problem for the healthcare system, doctors, and patients. With an aging population, more and more individuals are developing neurodegenerative diseases and there are few treatment options at the present time.
Andrew B, Newberg +5 more
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Oxysterols and neurodegenerative diseases
Molecular Aspects of Medicine, 2009In contrast to their parent molecule cholesterol, two of its side-chain oxidized metabolites are able to cross the blood-brain barrier. There is a concentration-driven flux of 24S-hydroxycholesterol (24S-OHC) from the brain into the circulation, which is of major importance for elimination of excess cholesterol from the brain.
Björkhem I +3 more
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MicroRNAs in Neurodegenerative Diseases
2017MicroRNAs are small noncoding RNAs that regulate gene expression at the posttranscriptional level in a sequence-specific manner. After their discovery in 1993, mounting data have provided compelling evidence for their causal involvement in several human diseases, such as cancer and disorders of the brain.
Sean, Quinlan +4 more
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Ceruloplasmin in neurodegenerative diseases
Biochemical Society Transactions, 2008Two decades ago, patients lacking circulating serum ceruloplasmin (Cp) presented with neurodegeneration associated with brain iron accumulation. These patients, with mutations in the MCO (multi-copper oxidase), Cp, revealed an essential role for Cp in iron homoeostasis.
Sarah J, Texel +2 more
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