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RBD and Neurodegenerative Diseases
Molecular Neurobiology, 2016Rapid eye movement (REM) sleep behavior disorder (RBD) is a sleep disorder characterized by enacting one's dreams during the REM sleep, with most of the dreams being violent or aggressive, so that patients often come to see the doctor complaining hurting themselves or bed partners during sleep.
Haiyang, Jiang +12 more
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Prions and Neurodegenerative Diseases
New England Journal of Medicine, 1987CREUTZFELDT–JAKOB disease (CJD), kuru, and the Gerstmann–Straussler syndrome are human neurodegenerative diseases that can be transmitted experimentally to animals.
Franklin H. Epstein, Stanley B. Prusiner
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Neurodegenerative Diseases and Ageing
2019This chapter describes the main neuropathological features of the most common age associated neurodegenerative diseases including Alzheimer's disease, Lewy body diseases, vascular dementia and the various types of frontotemporal lobar degeneration.
Walker L +3 more
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Neuroprotection and Neurodegenerative Disease
Journal of Clinical Neuroscience, 2002This paper will focus on commonalities in the aetiology and pathology in five areas of neurological disease with illustrative examples of therapy. Possibilities of multimodal and neuroprotective therapies in human disease, employing currently available drugs and showing evidence of neuroprotective potential in animal models, are discussed.
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Meditation and neurodegenerative diseases
Annals of the New York Academy of Sciences, 2013Neurodegenerative diseases pose a significant problem for the healthcare system, doctors, and patients. With an aging population, more and more individuals are developing neurodegenerative diseases and there are few treatment options at the present time.
Andrew B, Newberg +5 more
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Oxysterols and neurodegenerative diseases
Molecular Aspects of Medicine, 2009In contrast to their parent molecule cholesterol, two of its side-chain oxidized metabolites are able to cross the blood-brain barrier. There is a concentration-driven flux of 24S-hydroxycholesterol (24S-OHC) from the brain into the circulation, which is of major importance for elimination of excess cholesterol from the brain.
Björkhem I +3 more
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Ceruloplasmin in neurodegenerative diseases
Biochemical Society Transactions, 2008Two decades ago, patients lacking circulating serum ceruloplasmin (Cp) presented with neurodegeneration associated with brain iron accumulation. These patients, with mutations in the MCO (multi-copper oxidase), Cp, revealed an essential role for Cp in iron homoeostasis.
Sarah J, Texel +2 more
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Sleep in Neurodegenerative Diseases
Sleep Medicine Clinics, 2016Disorders of sleep are an integral part of neurodegenerative diseases and include insomnia, sleep-wake cycle disruption, excessive daytime sleepiness that may be manifested as persistent somnolence or sudden onset of sleep episodes, obstructive and central sleep apnea, rapid eye movement sleep behavior disorder, and restless legs syndrome.
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Metabolomics of Neurodegenerative Diseases
2015Neurodegenerative diseases are progressive, devastating, and terminal, carrying both personal and societal burden. Currently, their diagnosis depends on their clinical presentation. No quantitative biomarkers exist to enable early verdict and commencement of therapy.
Alejandro, Botas +3 more
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Ageing and neurodegenerative diseases
Ageing Research Reviews, 2010Ageing, which all creatures must encounter, is a challenge to every living organism. In the human body, it is estimated that cell division and metabolism occurs exuberantly until about 25 years of age. Beyond this age, subsidiary products of metabolism and cell damage accumulate, and the phenotypes of ageing appear, causing disease formation.
Chia-Wei, Hung +4 more
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