Results 291 to 300 of about 415,236 (314)

Cannabinoids and Neurodegenerative Diseases

CNS & Neurological Disorders - Drug Targets, 2009
Although significant advances have taken place in recent years on our understanding of the molecular mechanisms of different neurodegenerative diseases, its translation into effective therapeutic treatments has not been as successful as could be expected.
J, Romero, J Martínez, Orgado
openaire   +2 more sources

Curcuminoids in Neurodegenerative Diseases

Recent Patents on CNS Drug Discovery, 2012
Neurodegeneration is a term used to describe progressive deterioration of structure and/or function of neurons that affects different parts of the central nervous system and leads to eventual death. Neurodegenerative diseases include Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), Huntington's disease (HD), and ...
Darrick S H L, Kim, Jin Y, Kim, Yesun, Han   +2 more
openaire   +2 more sources

Ceruloplasmin in neurodegenerative diseases

Brain Research Reviews, 2005
For decades, abnormalities in ceruloplasmin (Cp) synthesis have been associated with neurodegenerative disease. From the early observation that low circulating serum ceruloplasmin levels served as a marker for Wilson's disease to the recent characterization of a neurodegenerative disorder associated with a complete lack of serum ceruloplasmin, the link
Vassiliev V, Harris ZL, Zatta P.
openaire   +3 more sources

Minocycline and neurodegenerative diseases

Behavioural Brain Research, 2009
Minocycline is a semi-synthetic, second-generation tetracycline analog which is effectively crossing the blood-brain barrier, effective against gram-positive and -negative infections. In addition to its own antimicrobacterial properties, minocycline has been reported to exert neuroprotective effects over various experimental models such as cerebral ...
Hye-Sun, Kim, Yoo-Hun, Suh
openaire   +2 more sources

Microglia in neurodegenerative disease

Nature Reviews Neurology, 2010
Microglia, the resident macrophages of the CNS, are exquisitely sensitive to brain injury and disease, altering their morphology and phenotype to adopt a so-called activated state in response to pathophysiological brain insults. Morphologically activated microglia, like other tissue macrophages, exist as many different phenotypes, depending on the ...
Perry, V. Hugh, Nicoll, James A.R., Holmes, Clive   +2 more
openaire   +3 more sources

Biomarkers for neurodegenerative diseases

Current Opinion in Neurology, 2005
A major goal of current clinical research in neurodegenerative diseases is to improve early detection of disease and presymptomatic detection of neuronal dysfunction. We also need better tools to assess disease progression in this group of disorders.
Susie M D, Henley, Gillian P, Bates, Sarah J, Tabrizi   +2 more
openaire   +2 more sources

Anosognosia in neurodegenerative disease

Neurocase, 2011
Patients with neurological disorders are often partially or completely unaware of the deficits caused by their disease. This impairment is referred to as anosognosia, and it is very common in neurodegenerative disease, particularly in frontotemporal dementia.
openaire   +2 more sources

Prions and neurodegenerative diseases

Current Opinion in Genetics & Development, 2000
The long-term, progressive decay of the central nervous system typifies prion diseases, a group of rare, transmissible maladies affecting humans, sheep, cattle and some other types of mammal. Little is known about the early molecular events in its pathogenesis but the diverse roles of PrP, the prion protein, in its destructive action have recently been
openaire   +2 more sources

Sleep and Neurodegenerative Diseases

Seminars in Neurology, 2009
Sleep disturbances are common in neurodegenerative diseases. Disturbed sleep can result in fatigue, irritability, morning headaches, impaired motor and cognitive skills, depression, and daytime somnolence. The major sleep complaints include insomnia, hypersomnia, parasomnia, excessive nocturnal motor activity, circadian sleep-wake rhythm disturbance ...
openaire   +2 more sources

Biomarkers in Neurodegenerative Diseases

2017
The past decade has seen tremendous efforts in biomarker discovery and validation for neurodegenerative diseases. The source and type of biomarkers has continued to grow for central nervous system diseases, from biofluid-based biomarkers (blood or cerebrospinal fluid (CSF)), to nucleic acids, tissue, and imaging.
Andreas, Jeromin, Robert, Bowser
openaire   +2 more sources