Results 321 to 330 of about 9,268,601 (369)

TDP-43 as a potential retinal biomarker for neurodegenerative diseases. [PDF]

Front Neurosci
Glashutter M, Wijesinghe P, Matsubara JA.   +2 more
europepmc   +1 more source

MeCP2 Lactylation Protects against Ischemic Brain Injury by Transcriptionally Regulating Neuronal Apoptosis

Advanced Science, EarlyView.
MeCP2 lactylation protects against ischemic stroke by reducing brain infarct volume and improving neurological outcomes. Lactylation at K210/K249 exerts neuroprotective effects by repressing the transcription of apoptosis‐associated genes, including Pdcd4 and Pla2g6. HDAC3 and p300 serve as key regulatory enzymes for MeCP2 lactylation following stroke.
Min Sun, Yuxin Zhang, Rui Mao, Yan Chen, Pinyi Liu, Lei Ye, Siyi Xu, Junqiu Jia, Shu Shu, Huiya Li, Yanping Yin, Shengnan Xia, Yanting Chen, Yun Xu   +13 more
wiley   +1 more source

VPS35-Retromer: Multifunctional Roles in Various Biological Processes - A Focus on Neurodegenerative Diseases and Cancer. [PDF]

J Inflamm Res
Fan X, Xie Y, Cao S, Zhu L, Wang X.
europepmc   +1 more source

Development of MDM2‐Targeting PROTAC for Advancing Bone Regeneration

Advanced Science, EarlyView.
This work presents a creative pipeline for developing MDM2‐targeting PROTACs (MDM2‐PROTACs) for application in bone regeneration. The developed PROTACs (CL144 and CL174) are validated for their degradation efficiency and osteogenic effects in human BMSCs.
Sol Jeong, Jae‐Kook Cha, Wasim Ahmed, Jaewan Kim, Minsup Kim, Kyung Tae Hong, Wonji Choi, Sunjoo Choi, Tae Hyeon Yoo, Hyun‑Ju An, Seung Chan An, Jaemin Lee, Jimin Choi, Sun‐Young Kim, Jun‐Seok Lee, Soonchul Lee, Junwon Choi, Jin Man Kim   +17 more
wiley   +1 more source

Ferroptosis in neurodegenerative diseases: mechanisms and therapeutic potential of stem cell derivatives. [PDF]

Front Cell Dev Biol
Zhang T, Zhang Y, Xie J, Lu D, Wang L, Zhao S, Zhou J, Cheng Y, Kou T, Wang J, Chen Y, Xu L, Hu X, Ying Y, Wang J, Xin X, Xu X, Lei S, Qiu C, Wu J, Lyu Q, Cao T.   +21 more
europepmc   +1 more source

Insights into Siglec‐7 Binding to Gangliosides: NMR Protein Assignment and the Impact of Ligand Flexibility

Advanced Science, EarlyView.
The molecular recognition of the sugar moiety of GD3 and Gb3 (globotriaosylceramide) derivatives by Siglec‐7 has been thoroughly studied offering insights for cancer diagnostics and therapies. A combination of structural biology techniques, nuclear magnetic resonance (NMR) spectroscopy, physicochemical analysis, and in silico methods suggested that ...
Cristina Di Carluccio, Luis Padilla‐Cortés, Marta Tiemblo‐Martìn, Giulia Roxana Gheorghita, Rosario Oliva, Linda Cerofolini, Alessandro Antonio Masi, Celeste Abreu, Hsin‐Kai Tseng, Antonio Molinaro, Pompea Del Vecchio, Ondřej Vaněk, Chun‐Cheng Lin, Roberta Marchetti, Marco Fragai, Alba Silipo   +15 more
wiley   +1 more source

Selenoproteins: Zoom-In to Their Metal-Binding Properties in Neurodegenerative Diseases. [PDF]

Int J Mol Sci
Duță C, Muscurel C, Dogaru CB, Stoian I.   +3 more
europepmc   +1 more source

Improving Adult Vision Through Pathway‐Specific Training in Augmented Reality

Advanced Science, EarlyView.
Traditional perceptual training approaches are limited by stimulus specificity, treatment efficacy, and patient compliance. A novel altered reality (AR) method is developed to enhance pathway‐specific functions in human adults while performing everyday activities.
Yige Gao, Yulian Zhou, Qing He, Wen Wen, Peng Zhang   +4 more
wiley   +1 more source