Results 61 to 70 of about 9,301,430 (292)

Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases

Signal Transduction and Targeted Therapy
The human gastrointestinal tract is populated with a diverse microbial community. The vast genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every aspect of human biology, including health maintenance, development ...
Jian Sheng Loh, Wen Qi Mak, Lily Tan, Chu Xin Ng, Hong Hao Chan, Shiau Hueh Yeow, J. Foo, Y. Ong, C. W. How, K. Khaw   +9 more
semanticscholar   +1 more source

Elevated Levels of Methylmalonate and Homocysteine in Parkinson's Disease, Progressive Supranuclear Palsy and Amyotrophic Lateral Sclerosis [PDF]

, 2010
Background/Aims: Increasing evidence suggests that elevated levels of homocysteine (Hcy) and methylmalonate (MMA) may be involved in the pathogenesis of neurodegenerative diseases. Methods: The urine levels of MMA and serum levels of Hcy as well as folic
Bötzel, Kai, Giese, Armin, Levin, Johannes, Lorenzl, Stefan, Vogeser, Michael   +4 more
core   +1 more source

TDP-43 proteinopathies: a new wave of neurodegenerative diseases

Journal of Neurology Neurosurgery & Psychiatry, 2020
Inclusions of pathogenic deposits containing TAR DNA-binding protein 43 (TDP-43) are evident in the brain and spinal cord of patients that present across a spectrum of neurodegenerative diseases.
E. M. J. de Boer, Viyanti K Orie, T. Williams, M. Baker, H. D. De Oliveira, T. Polvikoski, Matthew Silsby, P. Menon, M. V. D. van den Bos, G. Halliday, L. H. van den Berg, L. Van Den Bosch, P. van Damme, M. Kiernan, M. V. van Es, S. Vucic   +15 more
semanticscholar   +1 more source

Mitochondrial dynamics–fusion, fission, movement, and mitophagy–in neurodegenerative diseases [PDF]

, 2009
Neurons are metabolically active cells with high energy demands at locations distant from the cell body. As a result, these cells are particularly dependent on mitochondrial function, as reflected by the observation that diseases of mitochondrial ...
Alexander, Baloyannis, Banchs, Bossy-Wetzel, Brockmann, Cassidy-Stone, Chang, Chen, Cho, Clark, D. C. Chan, de Brito, Delettre, Dodson, Exner, Fransson, Frezza, Gispert, H. Chen, Hollenbeck, Kim, Kim, Li, Liot, Lustbader, Macaskill, Meeusen, Milone, Mortiboys, Okamoto, Orr, Park, Parone, Popp, Reis, Suen, Ten Dijke, Trushina, Wang, Waterham, Wood-Kaczmar, Zuchner, Z  chner   +42 more
core   +3 more sources

Anti-aggregant tau mutant promotes neurogenesis

Molecular Neurodegeneration, 2017
Background The microtubule-associated protein Tau plays a role in neurodegeneration as well as neurogenesis. Previous work has shown that the expression of the pro-aggregant mutant Tau repeat domain causes strong aggregation and pronounced neuronal loss ...
Maria Joseph, Marta Anglada-Huguet, Katharina Paesler, Eckhard Mandelkow, Eva-Maria Mandelkow   +4 more
doaj   +1 more source

Highly efficient intercellular spreading of protein misfolding mediated by viral ligand-receptor interactions

Nature Communications, 2021
Pathologic protein aggregates associated with neurodegenerative diseases have the ability to transmit to unaffected cells via extracellular vesicles or direct cell-to-cell contact. Here, Liu et al.
Shu Liu, André Hossinger, Stefanie-Elisabeth Heumüller, Annika Hornberger, Oleksandra Buravlova, Katerina Konstantoulea, Stephan A. Müller, Lydia Paulsen, Frederic Rousseau, Joost Schymkowitz, Stefan F. Lichtenthaler, Manuela Neumann, Philip Denner, Ina M. Vorberg   +13 more
doaj   +1 more source

Age-related cognitive effects of the COVID-19 pandemic restrictions and associated mental health changes in Germans

Scientific Reports, 2022
Restrictive means to reduce the spread of the COVID-19 pandemic have not only imposed broad challenges on mental health but might also affect cognitive health.
Inga Menze, Patrick Mueller, Notger G. Mueller, Marlen Schmicker   +3 more
doaj   +1 more source

The role of PARP1 in neurodegenerative diseases and aging

The FEBS Journal, 2021
Neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease (PD), are characterized by progressive memory loss and motor impairment. Aging is a major risk factor for neurodegenerative diseases.
Kanmin Mao, Guo Zhang
semanticscholar   +1 more source

Long-term dynamics of aberrant neuronal activity in awake Alzheimer’s disease transgenic mice

Communications Biology, 2021
To advance our understanding of aberrant neuronal activity in Alzheimer’s disease (AD) Korzhova et al. use in vivo two-photon calcium imaging to record activity from cortical neurons of awake APPPS1 transgenic mice over four weeks, during the early phase
V. Korzhova, P. Marinković, J. Rudan Njavro, P. M. Goltstein, F. Sun, S. Tahirovic, J. Herms, S. Liebscher   +7 more
doaj   +1 more source

Biomedical Informatics Applications for Precision Management of Neurodegenerative Diseases [PDF]

, 2018
Modern medicine is in the midst of a revolution driven by “big data,” rapidly advancing computing power, and broader integration of technology into healthcare. Highly detailed and individualized profiles of both health and disease states are now possible,
Jimenez-Maggoria, Gustavo, Lombardo, Joseph, Miller, Justin B., Shan, Guogen   +3 more
core   +2 more sources