Results 61 to 70 of about 241,511 (306)

Biomarkers in Neurodegenerative Diseases [PDF]

Biomedicines, 2022
An increasing number of people are affected by various neurodegenerative diseases each year, impacting the quality of life of millions of people worldwide [...]
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Advances in Neurodegenerative Diseases

Neurology International, 2022
A multitude of diseases presenting a wide variety of phenotypic appearances are included in neurodegenerative disorders [...]
Vasileios Siokas, Efthimios Dardiotis
openaire   +3 more sources

The role of clearance mechanisms in the kinetics of toxic protein aggregates involved in neurodegenerative diseases [PDF]

, 2020
Protein aggregates in the brain play a central role in cognitive decline and structural damage associated with neurodegenerative diseases. For instance, in Alzheimer's disease the formation of Amyloid-beta plaques and tau proteins neurofibrillary tangles follows from the accumulation of different proteins into large aggregates through specific ...
arxiv   +1 more source

Characterization and clinical use of inflammatory cerebrospinal fluid protein markers in Alzheimer’s disease

Alzheimer’s Research & Therapy, 2018
Background Neuroinflammation has gained increasing attention as a potential contributing factor in Alzheimer’s disease (AD) pathology. A clinical cerebrospinal fluid biomarker capable of monitoring this process during the course of the disease has yet to
Frederic Brosseron, Andreas Traschütz, Catherine N. Widmann, Markus P. Kummer, Pawel Tacik, Francesco Santarelli, Frank Jessen, Michael T. Heneka   +7 more
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Oxidative Stress in Neurodegenerative Diseases [PDF]

, 2022
Non peer ...
Domanskyi, Andrii, Parlato, Rosanna
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Klotho pathways, myelination disorders, neurodegenerative diseases, and epigenetic drugs [PDF]

, 2020
In this review we outline a rationale for identifying neuroprotectants aimed at inducing endogenous Klotho activity and expression, which is epigenetic action, by definition. Such an approach should promote remyelination and/or stimulate myelin repair by
Chen, Xiaohong, Faller, Douglas V., Glavas, Ioannis P., Harpp, David N., Kanara, Iphigenia, Kodukula, Krishna, Mavrakis, Anastasios N., Moos, Walter H., Pernokas, Julie, Pernokas, Mark, Pinkert, Carl A., Powers, Whitney R., Sampani, Konstantina, Steliou, Kosta, Vavvas, Demetrios G., Zamboni, Robert J.   +15 more
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A novel CHCHD10 mutation implicates a Mia40‐dependent mitochondrial import deficit in ALS

EMBO Molecular Medicine, 2018
CHCHD10 mutations are linked to amyotrophic lateral sclerosis, but their mode of action is unclear. In a 29‐year‐old patient with rapid disease progression, we discovered a novel mutation (Q108P) in a conserved residue within the coiled‐coil‐helix‐coiled‐
Carina Lehmer, Martin H Schludi, Linnea Ransom, Johanna Greiling, Michaela Junghänel, Nicole Exner, Henrick Riemenschneider, Julie van der Zee, Christine Van Broeckhoven, Patrick Weydt, Michael T Heneka, Dieter Edbauer   +11 more
doaj   +1 more source

Age-related cognitive effects of the COVID-19 pandemic restrictions and associated mental health changes in Germans

Scientific Reports, 2022
Restrictive means to reduce the spread of the COVID-19 pandemic have not only imposed broad challenges on mental health but might also affect cognitive health.
Inga Menze, Patrick Mueller, Notger G. Mueller, Marlen Schmicker   +3 more
doaj   +1 more source

Mixture of Input-Output Hidden Markov Models for Heterogeneous Disease Progression Modeling [PDF]

arXiv, 2022
A particular challenge for disease progression modeling is the heterogeneity of a disease and its manifestations in the patients. Existing approaches often assume the presence of a single disease progression characteristics which is unlikely for neurodegenerative disorders such as Parkinson's disease.
arxiv  

Neurodegenerative Diseases and Autophagy [PDF]

, 2018
Most neurodegenerative diseases are characterized by the accumulation of aggregated proteins within neurons. These aggregate-prone proteins cause toxicity, a phenomenon that is further exacerbated when there is defective protein clearance.
Aflaki, Aflaki, Aguado, Aguib, Akizu, Al-Saif, Alves, Ando, Ando, Andrew, Argov, Argov, Arrasate, Ashkenazi, Axe, Ballabio, Belzil, Benjamin, Bento, Berger, Bernhardt, Biazik, Bitoun, Bjorkoy, Blanz, Blommaart, Boland, Bouhouche, Bryceson, Butzlaff, Byrne, Caccamo, Caccamo, Caccamo, Cadwell, Castillo, Castillo, Cataldo, Cataldo, Chan, Chang, Chen, Chen, Chen, Cheroni, Chesser, Chung, Cirulli, Citron, Coffey, Colacurcio, Conner, Corcelle-Termeau, Cortes, Cortes, Criado, Cullup, Cunha-Santos, Cunningham, Daud, Davies, de Duve, DeBosch, Decressac, Dehay, DeJesus-Hernandez, del Campo, Deng, Deretic, DeSelm, Di Bartolomeo, Dierks, Dionisi Vici, Dooley, Dowdle, Dressel, Du, Duran, Durcan, Durcan, Durieux, Egan, Eisenberg, Eisenberg, Emanuele, Endo, Fader, Fang, Farg, Farrer, Fecto, Fernandes, Filimonenko, Fink, Fleming, Fraldi, Freischmidt, Fujita, Fullgrabe, Furuta, Gal, Ganley, Ganley, Gatchel, Gautam, Ge, Ge, Ghavidel, Goedert, Goedert, Gomez-Sanchez, Goode, Graef, Haack, Hadano, Hamacher-Brady, Hamasaki, Hansen, Hara, Harms, Harris, Hawkins-Salsbury, Hayashi-Nishino, Heitman, Heo, Hirst, Hong, Hosokawa, Hsieh, Huang, Huett, Huotari, Ichimura, Itakura, Jaeger, Jahn, Jang, Jang, Jiang, Jung, Kamiya, Kane, Kaneb, Karanasios, Kaushik, Kazlauskaite, Kett, Khaminets, Khaminets, Khurana, Kim, Kim, Kim, Kim, Kimura, Kimura, Kirkin, Kitada, Knaevelsrud, Knorr, Komatsu, Komatsu, Komatsu, Komatsu, Kondapalli, Koyano, Kraft, Krasniak, Kruger, Kuma, Kyttala, Labuzek, Lacovich, Lamb, Laplante, Lazarou, Lee, Lee, Lee, Lee, Lee, Levine, Li, Li, Liang, Lin, Liu, Liu, Liu, Lloyd-Evans, Lloyd-Evans, Longatti, Lonskaya, Lonskaya, Lopez, Lopez de Maturana, Lu, Lu, Lunemann, Luty, Luzio, Lv, Ma, Ma, Magalhaes, Majid, Mancias, Mandell, Manzanillo, Marshall, Martinez-Vicente, Maruyama, Matikainen-Ankney, Mawuenyega, Mayer, Mazzulli, Mazzulli, McWilliams, Mealer, Medina, Melser, Menzies, Menzies, Menzies, Michaud, Millecamps, Minassian, Mizuno, Mizushima, Mizushima, Mizushima, Mochida, Moore, Moreau, Moreau, Morimoto, Murphy, Murray, Myeku, Nakatogawa, Narang, Narendra, Nascimento-Ferreira, Nazio, Newman, Nguyen, Nilsson, Nishiyama, Nixon, Nixon, Noda, Onofre, Ordureau, Orsi, Oz-Levi, Ozcelik, Pacheco, Palikaras, Pankiv, Papinski, Park, Park, Pavel, Perez, Pickford, Pickrell, Pilli, Piras, Platt, Potter, Poupetova, Proikas-Cezanne, Pryor, Puls, Puri, Pyo, Ramesh Babu, Randow, Ravikumar, Ravikumar, Ravikumar, Ravikumar, Ravikumar, Razi, Reinwald, Renvoise, Richards, Rockenstein, Roczniak-Ferguson, Rodriguez-Navarro, Rogov, Rohn, Roosen, Rose, Rubinsztein, Rubinsztein, Rui, Russell, Rusten, Saftig, Sahu, Saitsu, Sanchez-Martinez, Sandoval, Sanjuan, Sano, Sardiello, Sarkar, Sarkar, Sato, Schaeffer, Schreiber, Schroder, Sellier, Seok, Serrano-Puebla, Settembre, Settembre, Settembre, Shaid, Shen, Shibata, Shibutani, Siddiqi, Siddiqui, Simonsen, Singh, Small, Son, Sorbara, Sou, Spampanato, Spilman, Staats, Stadel, Sun, Sundaramoorthy, Svenning, Tan, Tanaka, Tang, Tanji, Teyssou, Thurston, Tian, Tian, Tiede, Tien, Tsuboyama, Tsunemi, Tumbarello, Ugolino, Ulgherait, Ushio, Valente, Vantaggiato, Varga, Velikkakath, Vidoni, Vingtdeux, Vollrath, Wang, Wang, Wang, Watabe, Webb, Webster, Weedon, Wei, West, Wild, Williams, Williams, Winklhofer, Winslow, Wolfe, Wong, Wraith, Wu, Xi, Yamamoto, Yazdankhah, Yla-Anttila, Yoshii, Yu, Yu, Yu, Yuan, Yue, Zare-Shahabadi, Zavodszky, Zhang, Zhang, Zhang, Zhang, Zhang, Zhao, Zhao, Zheng, Zhou, Zhou, Zuchner   +401 more
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