Results 101 to 110 of about 114,486 (309)

Paternal Caffeine Exposure Programs Offspring Stress Vulnerability via Sperm Dlk1‐Dio3 Imprinting‐Directed Remodeling of a Novel Neural Circuit

Advanced Science, EarlyView.
The study elucidates that paternal preconception stress can drive offspring hyperresponsivity of the stress system via hypomethylation of a specific DNA region in sperm. This key link is confirmed in a cohort of prospective fathers: the epigenetic alteration is associated with elevated stress hormone levels.
Mengxi Lu, Gaole Dai, Sen Zhu, Shuai Zhang, Tingting Wang, Yuan Meng, Fang Yang, Xiaoyi Han, Hui Wang, Hao Kou, Dan Xu   +10 more
wiley   +1 more source

Mdivi-1 improves cognitive dysfunction in immature SD rats induced by hypoxia combined with propofol by inhibiting excessive mitophagy

陆军军医大学学报
Objective To investigate the protective effect of mitochondrial division inhibitor 1 (Mdivi-1), a mitophagy inhibitor, on cognitive dysfunction in immature SD rats induced by hypoxia combined with propofol.
XU Yao, YANG Shun, YANG Fei
doaj   +1 more source

Combining Spatial Multi‐Omics Data to Decipher Spatial Domains and Elucidate Cell Heterogeneity Based on Self‐Supervised Graph Learning

Advanced Science, EarlyView.
A self‐supervised multi‐view graph fusion framework integrates spatial multi‐omics, excelling in domain identification and denoising. It reconstructs spatial pseudo‐expression, jointly analyzes multi‐omics data, infers RNA velocity, predicts spatial omics features from single‐cell multi‐omics, and detects spatially dark genes and transcription factors,
Yuejing Lu, Rui Qiao, Ying Li, Junhong Li, Nuoya Yue, Jing Ge, Jiao Wang, Luonan Chen, Peiluan Li   +8 more
wiley   +1 more source

A Self-led Self-management Intervention Supporting Teens with IBD (ASSIST-IBD): protocol for a feasibility study of a novel digital treatment adherence intervention

BMJ Open
Introduction Treatment non-adherence is common in young people with inflammatory bowel disease (IBD), yet support is lacking. A self-led self-management intervention supporting teens with IBD (ASSIST-IBD) is a new theory-based digital treatment adherence
Rafeeq Muhammed, Rachel Shaw, Gemma Heath, Lou Atkinson, Cassandra Screti   +4 more
doaj   +1 more source

Parenteral Nutrition Compromises Neurodevelopment of Preterm Pigs

, 2014
Background: Despite advances in nutritional support and intensive care, preterm infants are at higher risk of compromised neurodevelopment.
Buddington, Randal K., Karyl K Buddington, Choudhri, Asim F., Helen J Sable, Randal K Buddington, Viktor V Chizhikov, Asim F Choudhri, Buddington, Karyl K., Sable, Helen J., Chizhikov, Viktor V.   +9 more
core   +1 more source

“Membrane‐Guided” Repair Strategy: Precision Delivery of GGT1 Degrader for Targeted Repair and Regeneration of Spinal Cord Neurons

Advanced Science, EarlyView.
This study confirms that GGT1 is a key driver of neuronal ferroptosis following spinal cord injury. We developed NSCm@EA, a biomimetic delivery system coated with neural stem cell membranes, for precise delivery of enocyanin to injured neurons. By combining targeted delivery with ubiquitination degradation mechanisms, this system promotes MGRN1 ...
Tao Yang, Lei Ye, Peigen Xie, Tao Song, Jian Chen, Heng Zhao, Zhengshan Liu, Xi Chen, Jianing Ding, Xintian Ding, Ao Shao, Miaomiao Wu, Fengdong Zhao, Siyue Tao, Tao You   +14 more
wiley   +1 more source

A novel variant of DNM1L expanding the clinical phenotypic spectrum: a case report and literature review

BMC Pediatrics
Background Mitochondrial diseases are heterogeneous in terms of clinical manifestations and genetic characteristics. The dynamin 1-like gene (DNM1L) encodes dynamin-related protein 1 (DRP1), a member of the GTPases dynamin superfamily responsible for ...
Zhenkun Zhang, Xiaofan Bie, Zhehui Chen, Jing Liu, Zhenhua Xie, Xian Li, Mengjun Xiao, Qiang Zhang, Yaodong Zhang, Yanling Yang, Dongxiao Li   +10 more
doaj   +1 more source

A prospective natural history study of Krabbe disease in a patient cohort with onset between 6 months and 3 years of life

Orphanet Journal of Rare Diseases, 2018
Background Krabbe disease is a rare neurodegenerative disorder caused by a deficiency in the lysosomal enzyme galactocerebrosidase. Patients with Krabbe disease present with a variable disease course depending on their age of onset.
Nicholas Bascou, Anthony DeRenzo, Michele D. Poe, Maria L. Escolar   +3 more
doaj   +1 more source

Modulation of atypical brain activation during executive functioning in autism: a pharmacological MRI study of tianeptine

Molecular Autism, 2021
Background Autism spectrum disorder (ASD) is associated with deficits in executive functioning (EF), and these have been suggested to contribute to core as well as co-occurring psychiatric symptoms.
Robert H. Wichers, James L. Findon, Auke Jelsma, Vincent Giampietro, Vladimira Stoencheva, Dene M. Robertson, Clodagh M. Murphy, Sarah Blainey, Grainne McAlonan, Christine Ecker, Katya Rubia, Declan G. M. Murphy, Eileen M. Daly   +12 more
doaj   +1 more source

Delayed childhood neurodevelopment and neurosensory alterations in the second year of life in a prospective cohort of ZIKV-exposed children.

Nature Medicine, 2019
We report neurodevelopmental outcomes in 216 infants followed since the time of PCR-confirmed maternal Zika virus (ZIKV) infection in pregnancy during the Rio de Janeiro epidemic of 2015–2016 (refs. 1,2). Neurodevelopment was assessed by Bayley Scales of
K. Nielsen‐Saines, P. Brasil, T. Kerin, Zilton F. M. Vasconcelos, C. Gabaglia, L. Damasceno, Marcos V. Pone, L. M. Abreu de Carvalho, S. Pone, A. Zin, I. Tsui, T. R. S. Salles, D. C. da Cunha, R. P. Costa, Jociele Malacarne, A. B. Reis, R. Hasue, C. Aizawa, F. F. Genovesi, C. Einspieler, P. Marschik, J. Pereira, S. Gaw, K. Adachi, J. Cherry, Zhiheng Xu, G. Cheng, M. E. Moreira   +27 more
semanticscholar   +1 more source