Results 111 to 120 of about 114,486 (309)

Lactoferrin Deficiency During Lactation Causes Adult Obesity‐Related Metabolic Disease Through Persistent Adipose Dysfunction Driven by Impaired Adipocyte Development

Advanced Science, EarlyView.
Lactational lactoferrin deficiency exerts lasting effects on epididymal adipose tissue development from lactation into adulthood: it impairs adipocyte hyperplasia and induces pathological hypertrophy, resulting in lower body weight yet exacerbated metabolic dysfunction under a high‐fat diet in adulthood.
Qin An, Yunxia Zou, Wenli Wang, Zhimei Cheng, Zhuoxing Zhang, Ruwei Liu, Xiong Wang, Kunlun Huang, Fangrong Ding, Yunping Dai, Qingyong Meng, Yali Zhang   +11 more
wiley   +1 more source

Artificial intelligence for tracking social behaviours and supporting an autism spectrum disorder diagnosis: systematic review and meta-analysisResearch in context

EBioMedicine
Summary: Background: Artificial intelligence (AI) holds promise for developing tools that can track social behaviours and support clinical assessments and outcomes in Autism Spectrum Disorders (ASD).
Carter Sun, Alistair McEwan, Kelsie A. Boulton, Eleni Andrea Demetriou, Ayesha K. Sadozai, Amit Lampit, Adam J. Guastella   +6 more
doaj   +1 more source

Evaluating the INTER-NDA for standardised neurodevelopmental screening at 2 years of age for all children born preterm

Background: Children born preterm are at increased risk of compromised neurodevelopment. The risk of adverse neurodevelopmental outcomes increases with decreasing gestational age.
Agyeman-Duah, Josephine Nana Afrakoma
core   +1 more source

CHCHD10 Mitigates Alzheimer's Disease‐Related Phenotypes in Association With Epigenetic Remodeling in Directly Reprogrammed Neurons

Advanced Science, EarlyView.
CHCHD10 loss in Alzheimer's disease is associated with mitochondrial dysfunction, epigenomic disruption, and tau pathology. Restoration of CHCHD10 shifts DNA methylation toward a non‐disease state and reduces tau and amyloid pathology, with KATNAL2 acting as a downstream effector.
Teresa M. Thomas, Ching‐Yao Yang, Kexin Zhang, Liam Wetzel, Dina Bugybayeva, Julia Ferguson, Md Mahmudul Hasan, William Samsa, Nandita Patil, Anshul Dash, Tarini Gowda, Xiongwei Zhu, Feixiong Cheng, Tian Liu   +13 more
wiley   +1 more source

Joint distribution of chronic undernutrition status and neurodevelopment outcomes.

, 2023
Joint distribution of chronic undernutrition status and neurodevelopment outcomes.
Edson Serván-Mori (5474423), Carlos Pineda-Antunez (10687414), Abby Madrigal (12902470), Lourdes Schnaas (62668), Amado D. Quezada-Sánchez (12322792), María del Carmen Hernández-Chávez (12902467), Evelyn Fuentes-Rivera (8993756), Gerónimo Medrano (17327905), Angélica García-Martínez (12322789), Bárbara Guerrero (17327902), Raquel García-Feregrino (12902473)   +10 more
core   +1 more source

A Robust Deep Temporal Causal Discovery Platform for Single‐Cell Gene Regulatory Network Reconstruction

Advanced Intelligent Discovery, EarlyView.
scTIGER2.0 is a deep‐learning framework that infers gene regulatory networks from single‐cell RNA sequencing data. By integrating correlation, pseudotime ordering, deep learning and bootstrap‐based significance testing, it reduces false positives and reveals directional gene interactions.
Nishi Gupta, Madison Dautle, Shaoqiang Zhang, Yong Chen   +3 more
wiley   +1 more source

Smoking and alcohol drinking during pregnancy as the risk factors for poor child neurodevelopment – A review of epidemiological studies

, 2015
Maternal active and passive smoking and low or moderate alcohol drinking during pregnancy, taking into account the level of exposure and developmental or behavioral outcomes, are recognized as a significant issue from both a clinical and a public health ...
Joanna Jurewicz, Wojciech Hanke
core   +1 more source

The 9th International RASopathies Symposium

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT The RASopathies are a group of congenital disorders with overlapping clinical manifestations that are caused by pathogenic germline or early somatic variants that result in the hyperactivation of the RAS/mitogen‐activated protein kinase (MAPK) signaling pathway.
Pau Castel, Lisa Schoyer, Beth Stronach, Raya Bogdanova, Anton M. Bennett, Jaishri Blakeley, Miriam Bornhorst, Tammy Bowers, Saskia M. Brachmann, Emma Burkitt‐Wright, Kathryn Chatfield, Alessandro De Luca, Khalil El‐Chammas, Abdul Elkadri, John E. Fortunato, Bruce D. Gelb, Anne Goriely, Karen Gripp, Kassidy Grover, Lindsay Homan, Kenneth A. Kern, Maija Kiuru, Charles (Chuck) Lawson, Yong‐Seok Lee, Frank McCormick, Gina Ney, Cristina Nuevo‐Tapioles, Sara Pardej, Elizabeth I. Pierpont, Julia Plank, Nancy Ratner, Katherine A. Rauen, J. Elliott Robinson, Les Rogers, Sarah E. Sheppard, Keir Shiels, David Stevenson, Dagmar Tiemens, Matthew Traylor, K. Nicole Weaver, Marielle Yohe, Tamar Green   +41 more
wiley   +1 more source

Intergenerational associations in inhibitory control in FMR1 families

Frontiers in Psychiatry
Inhibitory control (IC), the capacity to resist or suppress a dominant or automatic response, is a central component of self-regulation and executive functioning.
Erin E. Hunt, Erin E. Hunt, Holley P. Arnold, Holley P. Arnold, Kaitlyn B. Cortez, Kaitlyn B. Cortez, Jane E. Roberts, Jane E. Roberts   +7 more
doaj   +1 more source

Mercury, APOE, and children's neurodevelopment

, 2014
The benefit of the nutritious elements in fish is insufficient for explaining the controversial finding regarding prenatal mercury (Hg) exposure and neurodevelopment; the varying frequency of susceptible genes among these populations may shed light on ...
Ng, Sharon;Lin, Ching-Chun;Hwang, Yaw-Huei;Hsieh, Wu-Shiun;Liao, Hua-Fang;Chen, Pau-Chung, 陳保中 ;謝武勳 ;黃耀輝 ;廖華芳   +1 more
core   +1 more source