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Pediatric Discovery, EarlyView.Through network pharmacology and molecular docking, it has been discovered that CA can target MAOB, among other proteins, to exert a therapeutic effect in IBS. In vivo, CA lowered visceral hypersensitivity, anxiety and depression‐like behaviors, and fecal water content, highlighting its therapeutic potential for IBS via anti‐inflammatory pathways ...
Qingyang Yu +4 more
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Pediatric Discovery, EarlyView.Utilizing network toxicology, molecular docking, and dynamic simulations to investigate the potential reproductive toxicity of bisphenol S (BPS). ABSTRACT The aim of this study was to investigate the potential reproductive toxicity of bisphenol S (BPS) and the related molecular mechanisms through a network toxicology approach.
Siyuan Wang +7 more
wiley +1 more source
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Current Opinion in Neurobiology, 2012
Franck Polleux is a Professor at The Scripps Research Institute in La Jolla, California. He was an Associate Professor at University of North Carolina – Chapel Hill. Dr Polleux was trained at INSERM U371 in Bron, France and then in the Department of Neuroscience at Johns Hopkins University in Baltimore.
Joseph G, Gleeson, Franck, Polleux
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Franck Polleux is a Professor at The Scripps Research Institute in La Jolla, California. He was an Associate Professor at University of North Carolina – Chapel Hill. Dr Polleux was trained at INSERM U371 in Bron, France and then in the Department of Neuroscience at Johns Hopkins University in Baltimore.
Joseph G, Gleeson, Franck, Polleux
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Norepinephrine, neurodevelopment and behavior
Neurochemistry International, 2020Neurotransmitters play critical roles in the developing nervous system. Among the neurotransmitters, norepinephrine (NE) is in particular postulated to be an important regulator of brain development. NE is expressed during early stages of development and is known to regulate both the development of noradrenergic neurons and the development of target ...
Ehsan, Saboory +2 more
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Critical aspects of neurodevelopment
Neurobiology of Learning and Memory, 2021Organisms have the unique ability to adapt to their environment by making use of external inputs. In the process, the brain is shaped by experiences that go hand-in-hand with optimisation of neural circuits. As such, there exists a time window for the development of different brain regions, each unique for a particular sensory modality, wherein the ...
Ranabir, Chakraborty +2 more
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2020
Abstract The pre- and post-natal development of the human nervous system is briefly described, with special emphasis on the brain, particularly the cerebral and cerebellar cortices. The central nervous system originates from a specialized region of the ectoderm—the neural plate—which develops into the neural tube. The rostral part of the
Karl Zilles, Nicola Palomero-Gallagher
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Abstract The pre- and post-natal development of the human nervous system is briefly described, with special emphasis on the brain, particularly the cerebral and cerebellar cortices. The central nervous system originates from a specialized region of the ectoderm—the neural plate—which develops into the neural tube. The rostral part of the
Karl Zilles, Nicola Palomero-Gallagher
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Antiepileptic drugs and neurodevelopment
Current Neurology and Neuroscience Reports, 2006Clinical studies have documented the teratogenic potential of antiepileptic drugs (AEDs). More recent cohort studies have been trying to sort out which AEDs impose the highest risk of teratogenicity. Currently, there is evidence demonstrating an increased risk of major congenital malformations (MCMs) for valproate, phenobarbital, and polytherapy during
Gholam K, Motamedi, Kimford J, Meador
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Neurodevelopment in Children with Albinism
Ophthalmology, 2008To evaluate neurologic development in children with albinism.Observational cohort series.Seventy-eight children with albinism, ages 4 to 18 years.Parents completed a developmental questionnaire and were interviewed to evaluate their child for attention deficit hyperactivity disorder (ADHD) utilizing Diagnostic and Statistical Manual IV criteria.
Beth R, Kutzbach +3 more
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Schizophrenia as a Disorder of Neurodevelopment
Annual Review of Neuroscience, 2002▪ Abstract A combination of genetic susceptibility and environmental perturbations appear to be necessary for the expression of schizophrenia. In addition, the pathogenesis of the disease is hypothesized to be neurodevelopmental in nature based on reports of an excess of adverse events during the pre- and perinatal periods, the presence of cognitive ...
David A, Lewis, Pat, Levitt
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Pollution, the thyroid and neurodevelopment.
La Clinica terapeutica, 2016The global prevalence of neurodevelopmental diseases is on the rise. The number of autistic babies in the US has jumped from 1 in 68 to 1 in 42. Plus more and more children have attention disorders or hyperactivity disorders. The genetic causes of these disorders of neurological development cannot explain such radical increases in the incidence and ...
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