Common CHD8 Genomic Targets Contrast With Model-Specific Transcriptional Impacts of CHD8 Haploinsufficiency. [PDF]
, 2018 The packaging of DNA into chromatin determines the transcriptional potential of cells and is central to eukaryotic gene regulation. Case sequencing studies have revealed mutations to proteins that regulate chromatin state, known as chromatin remodeling ...
Catta-Preta, Rinaldo +3 more
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Therapeutic Environment and Premature newborns Development [PDF]
, 2019 Introduction: Prematurity is the leading cause of neonatal mortality, however, the survival of preterm infants is guaranteed. Prolonged exposure to numerous sensory stimuli during early neonatal intensive care units contributes to the increased ...
Calado, Gabriela, Costa, Mónica
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Orphanet Journal of Rare Diseases, 2018 Background Krabbe disease is a rare neurodegenerative disorder caused by a deficiency in the lysosomal enzyme galactocerebrosidase. Patients with Krabbe disease present with a variable disease course depending on their age of onset.
Nicholas Bascou +3 more
doaj +1 more source
Patient-derived iPSCs show premature neural differentiation and neuron type-specific phenotypes relevant to neurodevelopment. [PDF]
, 2018 Ras/MAPK pathway signaling is a major participant in neurodevelopment, and evidence suggests that BRAF, a key Ras signal mediator, influences human behavior.
Camacho, FM +10 more
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BMJ OpenIntroduction Treatment non-adherence is common in young people with inflammatory bowel disease (IBD), yet support is lacking. A self-led self-management intervention supporting teens with IBD (ASSIST-IBD) is a new theory-based digital treatment adherence
Rafeeq Muhammed +4 more
doaj +1 more source
Latest clinical recommendations on valproate use for migraine prophylaxis in women of childbearing age. Overview from European Medicines Agency and European Headache Federation [PDF]
, 2018 Migraine is a common and burdensome neurological condition which affects mainly female patients during their childbearing years. Valproate has been widely used for the prophylaxis of migraine attacks and is also included in the main European Guidelines ...
Dogne, Jean-Michel +5 more
core +2 more sources
ERP correlates of word onset priming in infants and young children
Developmental Cognitive Neuroscience, 2014 Using word onset priming with early learned words, we tracked access to phonological representations and predictive phonological processing at 6, 12, 18, and 24 months after birth.
Angelika B.C. Becker +2 more
doaj +1 more source
Frontiers in Neurology, 2020 Midkine (MK) is a small secreted heparin-binding protein highly expressed during embryonic/fetal development which, through interactions with multiple cell surface receptors promotes growth through effects on cell proliferation, migration, and ...
Emily Ross-Munro +9 more
doaj +1 more source
The many roads to psychosis: recent advances in understanding risk and mechanisms. [PDF]
, 2018 Schizophrenia is a chronic and severe mental illness which frequently leads to substantial lifelong disability. The past five years have seen major progress in our understanding of the complex genetic architecture of this disorder.
Bearden, Carrie E, Forsyth, Jennifer K
core
Association of a MET genetic variant with autism-associated maternal autoantibodies to fetal brain proteins and cytokine expression. [PDF]
, 2011 The contribution of peripheral immunity to autism spectrum disorders (ASDs) risk is debated and poorly understood. Some mothers of children with ASD have autoantibodies that react to fetal brain proteins, raising the possibility that a subset of ASD ...
Ashwood, P +4 more
core +2 more sources