Results 111 to 120 of about 1,437,159 (301)

Reversing Neurodevelopmental Disorders in Adults [PDF]

, 2008
Abnormalities in brain development, thought to be irreversible in adults, have long been assumed to underlie the neurological and psychiatric symptoms associated with neurodevelopmental disorders.
Michael P. Stryker, Ehninger, Dan, Stryker, Michael P., Li, Weidong, Fox, Kevin, Weidong Li, Kevin Fox, Dan Ehninger, Alcino J. Silva, Silva, Alcino J.   +9 more
core   +1 more source

Gestational Hypoxia Disrupts Medial Ganglionic Eminence Progenitor Dynamics and Interneuron Development in Schizophrenia

Advanced Science, EarlyView.
FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni, Qiancheng Zhang, Youhui Jiang, Huiying Yao, Chuqing Zhou, Xiaoyi Tian, Shiyingnan Gao, Jun Zhao, Xinyi Ren, Naxin Xu, Mengshan Fu, Liansheng Zhao, Xueyu Qi, Xueli Yu, Wanjun Guo, Sangmi Chung, Fan Guo, Tao Li   +17 more
wiley   +1 more source

Children and Adolescents with Neurodevelopmental Disabilities: Ecological Assessment Tools and Cognitive Analysis

The Special Issue, “Children and Adolescents with Neurodevelopmental Disabilities: Ecological Assessment Tools and Cognitive Analysis,” brings together a diverse collection of articles that highlight the rapidly evolving landscape of ...
Yael Fogel, Josman, Naomi, Naomi Josman, Fogel, Yael   +3 more
core   +1 more source

Long Noncoding RNA PCALRx Interacts with Pyruvate Carboxylase to Drive Multi‐Organ Developmental Toxicity in Zebrafish Embryos Exposed to Amoxicillin

Advanced Science, EarlyView.
Embryonic amoxicillin exposure disrupts multi‐organ development in zebrafish larvae through a lncRNA–metabolic enzyme regulatory axis. PCALRx associates with pyruvate carboxylase, promotes PC protein ubiquitination, and impairs mitochondrial energy metabolism, while vitamin B1 partially restores PC‐centered metabolic function and developmental outcomes.
Yixue Yao, Ping Jiang, Xinli Zhou, Mengying Yin, Qiong Luo, Hui Wang   +5 more
wiley   +1 more source

Neurodevelopmental Disorders Associated with Gut Microbiome Dysbiosis in Children

The formation of the human gut microbiome initiates in utero, and its maturation is established during the first 2–3 years of life. Numerous factors alter the composition of the gut microbiome and its functions, including mode of delivery, early onset of
Juan J. Borrego, Alejandro Borrego-Ruiz
core   +1 more source

Inflammation Unchecked: Concurrent Kawasaki Disease and Stevens‐Johnson Syndrome in an 18‐Month‐Old Child

Arthritis Care &Research, EarlyView.
Catherine Deffendall, Jodi Backalar, Elizabeth Acevedo Zapata, Adriana Della Porta, Lorin Bibb, Tyler Reese, Charlotte M. Brown   +6 more
wiley   +1 more source

RNA Promotes Synapsin Condensates That Organize Synaptic Vesicles in Live Neurons and Enable Localized Translation in Reconstituted System

Advanced Science, EarlyView.
Condensates at synapses organize synaptic vesicles (SVs) and are crucial for efficient neurotransmitter release, yet how RNA contributes to this mesoscale architecture remains poorly understood. Here we uncover that RNA modulates synapsin–driven condensates.
Branislava Rankovic, Zachary M. Geisterfer, Akshita Chhabra, Vladimir M. Jovanovic, Ian Seim, Christian Hoffmann, Antonela Condric, Gerard Aguilar Pérez, Rinse de Boer, Lars T. Hofstede, Jingao Sun, Kiara Freitag, Katja Nowick, Marina Jendrach, Frank L. Heppner, Vladimir Despic, Michaela Müller‐McNicoll, Stephan Sigrist, Geert van den Bogaart, Sofiia Reshetniak, Amy S. Gladfelter, Dragomir Milovanovic   +21 more
wiley   +1 more source

Parent training tailored for parents with ADHD: a randomized controlled trial

BMC Psychiatry
Background Parents who themselves have Attention-Deficit/Hyperactivity Disorder (ADHD) tend to benefit less from conventional parent training (PT) interventions than parents without ADHD, reporting suboptimal effects on both parenting-related outcomes ...
Therese Lindström, Sofia Buddgård, Lena Westholm, Martin Forster, Sven Bölte, Tatja Hirvikoski   +5 more
doaj   +1 more source

EU-AIMS Longitudinal European Autism Project (LEAP): the autism twin cohort

Molecular Autism, 2018
ᅟ EU-AIMS is the largest European research program aiming to identify stratification biomarkers and novel interventions for autism spectrum disorder (ASD).
Johan Isaksson, Kristiina Tammimies, Janina Neufeld, Élodie Cauvet, Karl Lundin, Jan K. Buitelaar, Eva Loth, Declan G. M. Murphy, Will Spooren, Sven Bölte, the EU-AIMS LEAP group   +10 more
doaj   +1 more source

Clinical and Research Insights from Pre-Emptive Early Intervention for Neurodevelopmental Disorders: A Case Series

Background: Siblings of children with autism spectrum disorder (ASD) are considered biologically at risk of developing neurodevelopmental disorders (NDDs) that may involve sensorimotor, adaptive, and social–communication domains.
Biancardi, Stefania, Caporali, Camilla, Camilla Caporali, Giulia Purpura, Alice Restelli, Mantegazza, Giulia, Purpura, Giulia, Restelli, Alice, Giulia Mantegazza, Piazza, Elena, Cavallini, Anna, Stefania Biancardi, Silvia Annunziata, Anna Cavallini, Elena Piazza, Brivio, Michelle, Michelle Brivio, Annunziata, Silvia   +17 more
core   +1 more source