Results 121 to 130 of about 251,798 (312)

Investigation of Clinical, Laboratory, Imaging Findings and Histopathological Features of Patients with Gastric Neuroendocrine Cell Hyperplasia

Background/Aims: Neuroendocrine cell hyperplasia is a non-neoplastic proliferation of enterochromaffin-like cells and is considered a premalignant lesion because of their potential to progress to neuroendocrine tumor.
Ünlü, Şadiye Mehtat, Çoban, Burcu, Kahraman, Dudu Solakoğlu, Burcu Çoban, Kaya, Gamze Çapa, Şadiye Mehtat Ünlü, BENGİ, GÖKSEL, Dudu Solakoğlu Kahraman, BARLIK, FUNDA, Göksel Bengi, Gamze Çapa Kaya, Müjde Soytürk, Hakim, Gözde Derviş, SOYTÜRK, MÜJDE, Gözde Derviş Hakim, Funda Barlık   +15 more
core   +1 more source

Effect of Broad‐Spectrum Antibiotic Prophylaxis on Post‐Pancreatoduodenectomy Infectious Complications: Nationwide Inpatient Database Study in Japan

Annals of Gastroenterological Surgery, EarlyView.
Using a nationwide Japanese inpatient database, we evaluated whether broad‐spectrum antibiotic prophylaxis improves postoperative outcomes after pancreatoduodenectomy compared with narrow‐spectrum antibiotics. In propensity score–weighted analyses of 45 099 patients, broad‐spectrum prophylaxis was associated with significantly lower rates of intra ...
Hiroki Kitagawa, Shotaro Aso, Yuki Hirano, Kenichiro Uemura, Keita Kouzu, Satoru Matsuda, Hiroki Matsui, Kiyohide Fushimi, Junichi Sasaki, Yuko Kitagawa, Hideo Yasunaga   +10 more
wiley   +1 more source

Pancreatic Atrophy: A Narrative Review and Surgical Interpretation

Annals of Gastroenterological Surgery, EarlyView.
Pancreatic parenchymal atrophy pattern and intraoperative margin assessment guide surgical strategy. ABSTRACT Despite recent advances in multimodal management, pancreatic ductal adenocarcinoma remains a fatal malignancy. Early detection of indirect findings of pancreatic ductal adenocarcinoma is essential to improve treatment outcomes, drawing ...
Rika Fujino, Ken‐ichi Okada, Yohei Masugi, Eisuke Iwasaki, Masaki Mori   +4 more
wiley   +1 more source

Multicomponent Stapling of Glucagon‐Like Peptide‐1 Enables Receptor‐Guided PROTAC Delivery

Angewandte Chemie, EarlyView.
We report a stapled glucagon‐like peptide‐1 (GLP‐1) analogue created via multicomponent tryptophan‐mediated Petasis reaction (TMPR). This strategy yields a stabilised peptide with superior helicity and improved potency. Conjugation to a bromodomain‐containing protein 4 (BRD4) degrader creates the first GLP‐1‐guided targeted protein degrader (PROTAC ...
Jan L. Venne, Sona Krajcovicova, Graeme Davies, Hannah Bolt, Jefferson Revell, David R. Spring   +5 more
wiley   +2 more sources

Evidence that tyrosine hydroxylase does not have enzymatic activity in neurons of the supraoptic nucleus

Frontiers in Endocrinology
IntroductionAlthough numerous neurons expressing tyrosine hydroxylase (TH), the first enzyme of catecholamine synthesis, were discovered in the supraoptic nucleus (SON) of hypothalamus in animals almost forty years ago, mainly under osmotic stress, the ...
Tatiana S. Pronina, Dmitry V. Troshev, Anna A. Kolacheva, Vsevolod V. Bogdanov, Michael V. Ugrumov   +4 more
doaj   +1 more source

Automating AI Discovery for Biomedicine Through Knowledge Graphs and Large Language Models Agents

Advanced Intelligent Discovery, EarlyView.
This work proposes a novel framework that automates biomedical discovery by integrating knowledge graphs with multiagent large language models. A biologically aligned graph exploration strategy identifies hidden pathways between biomedical entities, and specialized agents use this pathway to iteratively design AI predictors and wet‐lab validation ...
Naafey Aamer, Muhammad Nabeel Asim, Shan Munir, Andreas Dengel   +3 more
wiley   +1 more source

π‐Extended COUPY Fluorophores for Targeted Near‐Infrared Fluorescence and Lifetime Imaging in Live Cells

Angewandte Chemie, EarlyView.
π‐Extended COUPY dyes, obtained by vinylogation of coumarin‐based COUPY scaffolds, shift absorption, and emission deep into the NIR region while preserving compactness and synthetic accessibility. These bright, photostable dyes enable live‐cell imaging, FLIM, and site‐specific peptide conjugation, offering a modular platform for targeted bioimaging and
Diego Abad‐Montero, Manel Bosch, Rodrigo Garcés‐Castellanos, Michael Q. Schottenhamel, Sergio Pedraza‐Arevalo, Alejandro Ibáñez‐Costa, Justo P. Castaño, Tania García‐Becerra, Elena Rebollo, Marta E. Alberto, Antonio Francés‐Monerris, Vicente Marchán   +11 more
wiley   +2 more sources

Hitherto unseen survival in an ALK‐positive‐patient with advanced stage adult ganglioneuroblastoma treated with personalized medicine

Clinical Case Reports, 2017
Key Clinical Message Survival of stage 4 ganglioneuroblastoma (GNB) patients is poor; no reports exist of patients surviving up to 5 years (1, 2). We report the clinical and therapeutic course of a patient with stage 4 GNB surviving beyond expectations ...
Signe Risum, Ulrich Knigge, Seppo W. Langer   +2 more
doaj   +1 more source

Pancreatic Divisum Associated with Ampullary Neuroendocrine Tumor and the Role of Magnetic Resonance Imaging

, 2017
Pancreatic divisum is the most common anomaly of the pancreas. Pancreatic divisum associated with malignant tumor is rarely seen. The ampulla of Vater is formed by the union of the common bile duct and the pancreatic duct.
Yaşar Bükte, Fatma Kulalı, Aslıhan Semiz Oysu   +2 more
core   +1 more source

Descriptive Epidemiology From the Myhre Syndrome Foundation Registry: The Value of Self‐Reported Data

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Myhre syndrome is an ultrarare genetic disease characterized by short stature, distinct craniofacial features, cardiovascular and respiratory fibrosis and stenosis, neurodevelopmental delays, autism, intellectual disability, and hearing loss. The natural history of Myhre syndrome is still not fully understood due to a small patient population ...
Mary K. Young, Armelle Pindon, Maggie R. Brand, Kate Wears, Katherine H. Young, Alyssa Mendel, Michael J. Lyons   +6 more
wiley   +1 more source