Results 101 to 110 of about 278,007 (254)
Advanced Science, EarlyView.Glucocorticoids (GC) are widely used to reduce inflammation. We show that the glucocorticoid receptor in myeloid cells regulates macrophage cell cycle and genome integrity during muscle regeneration. We demonstrate that dexamethasone administration during the early inflammatory phase delays muscle repair by increasing macrophage proliferation ...
Sirine Souali‐Crespo +11 more
wiley +1 more source
Acta Neuropathologica CommunicationsThe spectrum of frontotemporal dementia/amyotrophic lateral sclerosis (FTD/ALS) and Huntington disease (HD) are fatal neurodegenerative disorders with no major disease-modifying therapies. Recent work has shown that the hallmark pathological proteins TAR
Jennifer Oraha +5 more
doaj +1 more source
Everolimus and mTOR inhibition in pancreatic neuroendocrine tumors
, 2012 Kein-Leong YimVelindre Cancer Center, Cardiff, Wales, United KingdomAbstract: Pancreatic neuroendocrine tumors are rare and the majority of patients present in the advanced stage. Over the past few decades, treatment for patients with metastatic well- or
Yim K-L
core
Postirradiated Neuroendocrine Carcinoma of the Sinonasal Tract
, 2011 OBJECTIVES/HYPOTHESIS: Neuroendocrine carcinoma (NEC) of the sinonasal tract is rare. In this present study, we report our treatment experience with sinonasal NEC. STUDY DESIGN: Retrospective case series.
王成平;謝佳潁;張逸良;婁培人;楊宗霖;丁禮莉;柯政郁 +1 more
core +1 more source
Advanced Science, EarlyView.Using genetic code expansion, we engineered vascularized human cerebral organoids (vhCOs) with microglia‐like cells and blood‐brain barrier features. vhCOs recapitulate neurovascular interactions, regional identities, and neuronal subtypes resembling the fetal brain.
Haishuang Lin +7 more
wiley +1 more source
Targeting the YAP‐BST2 Axis Overcomes Intrinsic Anti‐PD‐1 Resistance in Metastatic Gastric Cancer
Advanced Science, EarlyView.Concurrent YAP hyperactivation and Tp53 loss in Atp4b‐expressed parietal cell lineage drives gastric cancer initiation, multi‐organ metastasis, and intrinsic resistance to anti‐PD‐1 therapy. BST2 emerges as a direct YAP‐TEAD transcriptional target that engages PIRA2 on myeloid cells to establish an immunosuppressive microenvironment.
Weihong Zhang +17 more
wiley +1 more source
Advanced Science, EarlyView.Orally administered recombinant human type III collagen protects the gastric mucosa from ethanol‐induced injury by coordinating redox homeostasis, epithelial barrier repair, and arachidonic acid–prostaglandin metabolism. Gastric digestion releases the pentapeptide GPAEF, which interacts with the Pla2g4a promoter G‐quadruplex in a structure‐dependent ...
Xinyue Lan +14 more
wiley +1 more source
European multicentre study on outcome of surgery for sporadic primary hyperparathyroidism
BJS (British Journal of Surgery), EarlyView., 2020 Some 5861 patients undergoing first‐time surgery for sporadic primary hyperparathyroidism were registered in the Eurocrine® database between 2015 and 2018. The use of intraoperative parathyroid hormone measurement decreased the risk of conversion and persistent hypercalcaemia.
A. Bergenfelz +3 more
wiley +1 more source
International Journal of Endocrinology, 2017 There are only a few published studies related to the population-based etiology of hypopituitarism. New risks for developing hypopituitarism have been recognized in the last 10 years. Aim.
M. Doknić +6 more
doaj +1 more source
Genitourinary Neuroendocrine Neoplasms
, 2020 Neuroendocrine neoplasms (NENs) of the genitourinary tract are uncommon, but the pathologist has to be prepared to recognize them and to assess the morphophenotypic factors that can drive their treatment and prognosis.
Silvia Uccella +5 more
core +1 more source