Results 101 to 110 of about 251,798 (312)

ISL1 expression is not restricted to pancreatic well-differentiated neuroendocrine neoplasms, but is also commonly found in well and poorly differentiated neuroendocrine neoplasms of extrapancreatic origin

, 2013
The human insulin gene enhancer-binding protein islet-1 (ISL1) is a transcription factor involved in the differentiation of the neuroendocrine pancreatic cells.
Hartmann, Arndt, Konukiewitz, Björn, Agaimy, Abbas, Rieker, Ralf J., Erlenbach-Wünsch, Katharina, Vieth, Michael, Kiesewetter, Franklin, Schmitt Kurrer, Anja, Zamboni, Giuseppe, Perren, Aurel, Klöppel, Günter   +10 more
core   +1 more source

Small Pancreas Neuroendocrine Tumors: How Small is Small?

, 2023
Objective: The current study aimed to investigate the issues in contemporary management strategies that focus on small pancreatic neuroendocrine tumors (PNETs).
Chia Hsun Hsieh, Hui-Jen Tsai, Ming-Huang Chen, Ching-Yao Yang, Li-Tzong Chen, On Behalf of Taiwan Neuroendocrine Tumor Society   +5 more
core   +1 more source

Heat Shock Protein 90: From Molecular Chaperone Function to Therapeutic Targeting in Malignancies

Advanced Science, EarlyView.
In this review, an integrated conceptual framework linking HSP90's molecular chaperone functions to its pathological roles in cancer is proposed. HSP90 serves as a central node that integrates oncogenic signaling, buffers proteotoxic stress, maintains cancer stem cell plasticity, and shapes tumor‐immune interactions, all of which converge to drive ...
Beibei Zhang, Xinxin Zou, Jiansong Zhou, Qinmiao Sun, Dahua Chen   +4 more
wiley   +1 more source

China Anti-Cancer Association guideline for diagnosis and treatment of neuroendocrine neoplasm (2022 edition)

Zhongguo aizheng zazhi, 2022
Neuroendocrine neoplasm (NEN) is a kind of rare tumor that originated from peptidergic neurons and neuroendocrine cells, which has neuroendocrine differentiation and expresses neuroendocrine markers.
of Neuroendocrine Neoplasm of China Anti-Cancer Association Society
doaj  

Clinical and molecular characterization of endocrine and neuroendocrine tumors

, 2007
Endocrine and neuroendocrine tumors are a heterogeneous groups of tumors which show peculiar biological pathways and clinical features. The comprehension of the peculiar biological mechanisms of endocrine and neuroendocrine cells has a relevant impact on
COLAO, ANNAMARIA
core  

Neuroendocrine Neoplasms of the Upper Aerodigestive Tract, Ear, and Salivary Glands

, 2020
Neuroendocrine neoplasms (NENs) of the head and neck (H&N) region include a heterogeneous group of neoplastic proliferations arising in the nasal cavity, paranasal sinuses, nasopharynx, larynx, salivary glands, middle ear, and skin.
Silvia Uccella, Uccella, Silvia, Stefano La Rosa, La Rosa, Stefano   +3 more
core   +1 more source

CCT2 Promotes Prostate Cancer Progression Through EIF3F‐Dependent Stabilization of FASN

Advanced Science, EarlyView.
ABSTRACT Prostate cancer (PCa) is increasingly recognized to be driven by dysregulated lipid metabolism. Although fatty acid synthase (FASN) is highly expressed in PCa, the mechanisms governing FASN protein stability and its functional integration into oncogenic lipid metabolism remain poorly defined.
Shun Xu, Yifan Zhang, Haolin Li, Shengyu Zhao, Xiaoran Dai, Qili Xu, Mintian Fei, Chun Li, Zhihui Zou, Baojun Wang, Li Zhang, Hui Wang, Ligang Zhang, Chaozhao Liang   +13 more
wiley   +1 more source

Cholesterol‐Mediated Metabolic‐mechanotransductive Crosstalk Orchestrates Castration Resistance in Prostate Cancer

Advanced Science, EarlyView.
Full androgen deprivation (FAD) induces paracrine cholesterol in prostate cancer that drives the polarization of cancer‐associated fibroblasts (CAFs) and subsequent elevated matrix stiffness. Matrix stiffness in turn potentiates tumor cell survival under FAD pressure via dual mechanotransductive activation of the IRE1α‐XBP1s stress‐response axis ...
Shaojie Liu, Chao Xu, Jun Jiang, Limin He, Yike Zhou, Zhengxuan Li, Yu Li, Keying Zhang, Fa Yang, Tong Lu, Hongtao Song, Hai Zhu, Zhihao Hu, Xiaolong Zhao, Kai Gan, Hongji Li, Bo Yang, Rui Zhang, Weihong Wen, Donghui Han, Weijun Qin   +20 more
wiley   +1 more source

Inhibition of KDEL Receptors Remodels the Tumor Microenvironment for T Cell Independent Tumor Regression

Advanced Science, EarlyView.
Inhibition of KDELR2 in a small fraction of tumor cells generates sustainable immunogenic cell death conditions within the tumor microenvironment. These conditions promote the regression of tumors in a T cell independent manner. During regression, macrophages prime T cells that subsequently provide systemic protection against recurrence. The potency of
Shakti P Pattanayak, Hong Wang, Belinda Willard, Timothy A. Chan, William C Merrick, Zheng‐Rong Lu, Boaz Tirosh   +6 more
wiley   +1 more source

Immunotherapy in the neoadjuvant treatment of gastrointestinal tumors: is the time ripe?

Journal for ImmunoTherapy of Cancer
Immune checkpoint inhibitors (ICIs) revolutionized the management of mismatch repair-deficient (dMMR)/microsatellite instability-high (MSI-H) gastrointestinal (GI) cancers.
Davide Ciardiello, Francesca Spada, Nicola Fazio, Maria Giulia Zampino, Lorenzo Gervaso, Rivadavio Antunes Oliveira, Michele Borghesani, Lorenzo Guidi, Lavinia Benini, Laura Algeri, Chiara Alessandra Cella   +10 more
doaj   +1 more source