Results 41 to 50 of about 251,798 (312)

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Tumor-derived apolipoprotein E confers resistance to temozolomide in pancreatic neuroendocrine tumors

Cell Death and Disease
Temozolomide (TMZ) is a first-class clinical drug for patients with pancreatic neuroendocrine tumors (pNETs). However, the therapeutic effects of TMZ are limited because of the chemoresistance of pNET cells, which has not been fully elucidated.
Xin Lou, Yihua Shi, Yi Qin, Wuhu Zhang, Zeng Ye, Fei Wang, Yan Wang, Tian Ding, Desheng Jing, Guixiong Fan, Yue Zhang, Xuemin Chen, Xiaowu Xu, Xianjun Yu, Shunrong Ji, Junfeng Xu   +15 more
doaj   +1 more source

Duodenal Gastric Metaplasia and Duodenal Neuroendocrine Neoplasms: More Than a Simple Coincidence? [PDF]

, 2022
Background: Duodenal gastric metaplasia (DGM) is considered a precancerous lesion. No data are available regarding its possible role as a risk factor for duodenal neuroendocrine neoplasms (dNENs).
Rossi, Roberta Elisa, on behalf of ItaNet (Italian Association for Neuroendocrine Tumours) Study Group on behalf of ItaNet (Italian Association for Neuroendocrine Tumours) Study Group, Nappo, Gennaro, Roberta Elisa Rossi, Sara Massironi, Valentina Andreasi, Milanetto, Anna Caterina, Stefano Partelli, Claudio Pasquali, Scaravaglio, Miki, Falconi, Massimo, Massironi, Sara, Davide Campana, On Behalf Of ItaNet Italian Association For Neuroendocrine Tumours Study Group, null, Francesco Panzuto, Invernizzi, Pietro, Massimo Falconi, Gennaro Nappo, Pasquali, Claudio, Pietro Invernizzi on behalf of ItaNet (Italian Association for Neuroendocrine Tumours) Study Group, Alessandro Zerbi, Andreasi, Valentina, Gallo, Camilla, Zerbi, Alessandro, Miki Scaravaglio, Campana, Davide, Partelli, Stefano, Camilla Gallo, Pietro Invernizzi, Anna Caterina Milanetto, Panzuto, Francesco   +30 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Hypoxia upregulating ACSS2 enhances lipid metabolism reprogramming through HMGCS1 mediated PI3K/AKT/mTOR pathway to promote the progression of pancreatic neuroendocrine neoplasms

Journal of Translational Medicine
Background Pancreatic neuroendocrine neoplasms (pNENs) are relatively rare. Hypoxia and lipid metabolism-related gene acetyl-CoA synthetase 2 (ACSS2) is involved in tumor progression, but its role in pNENs is not revealed.
Danyang Gu, Mujie Ye, Guoqin Zhu, Jianan Bai, Jinhao Chen, Lijun Yan, Ping Yu, Feiyu Lu, Chunhua Hu, Yuan Zhong, Pengfei Liu, Qibin He, Qiyun Tang   +12 more
doaj   +1 more source

DNA methylation reveals distinct cells of origin for pancreatic neuroendocrine carcinomas and pancreatic neuroendocrine tumors. [PDF]

, 2022
BACKGROUND Pancreatic neuroendocrine neoplasms (PanNENs) fall into two subclasses: the well-differentiated, low- to high-grade pancreatic neuroendocrine tumors (PanNETs), and the poorly-differentiated, high-grade pancreatic neuroendocrine carcinomas ...
Khouja, Slim, Bormann, Felix, Riemer, Pamela, Jarosch, Armin, Lenze, Dido, Horst, David, Marinoni, Ilaria, Detjen, Katharina, Rossner, Florian, Menne, Andrea, Childs, Liam H, Mamlouk, Soulafa, Simon, Tincy, Childs, Liam H., Blüthgen, Nils, Sers, Christine, Domenico, Annunziata Di, Di Domenico, Annunziata, Leser, Ulf, Monjé, Nanna, Pavel, Marianne, Capper, David, Morkel, Markus, Perren, Aurel   +23 more
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Obesity and Hypogonadism—A Narrative Review Highlighting the Need for High-Quality Data in Adolescents

Children, 2019
The prevalence of obesity continues to rise in adult and pediatric populations throughout the world. Obesity has a direct impact on all organ systems, including the reproductive system.
Tasnim Mushannen, Priscilla Cortez, Fatima Cody Stanford, Vibha Singhal   +3 more
doaj   +1 more source

Consensus Guidelines for High Grade Gastro-Entero Pancreatic (GEP) Neuroendocrine Tumours and Neuroendocrine Carcinomas (NEC). [PDF]

, 2016
Consensus Guidelines for High Grade Gastro-Entero Pancreatic (GEP) Neuroendocrine Tumours and Neuroendocrine Carcinomas (NEC)
Raymond, E, Caplin, M, Perren, A, Garcia-Carbonero, R, Ferone D, O'Toole, D, Anlauf, M, Niederle, B, Rindi, Guido, Baudin, E, Sedlackova, E, Toumpanakis, C, Sorbye, H, Wiedenmann, B, Cwikla, J B, Perren, Aurel   +15 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source