Results 61 to 70 of about 251,798 (312)

Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang, Dongxu Zhang, Dongyuan Liu, Da Lin, Hao Wang   +4 more
wiley   +1 more source

P53, Somatostatin receptor 2a and Chromogranin A immunostaining as prognostic markers in high grade gastroenteropancreatic neuroendocrine neoplasms

BMC Cancer, 2020
Background High grade gastroenteropancreatic (GEP) neuroendocrine neoplasms (NEN) with a Ki67 proliferation index > 20%, include well-differentiated tumours grade 3 (NET G3) and poorly differentiated (PD) neuroendocrine carcinomas (NEC).
Kirstine Nielsen, Tina Binderup, Seppo W. Langer, Andreas Kjaer, Pauline Knigge, Veronica Grøndahl, Linea Melchior, Birgitte Federspiel, Ulrich Knigge   +8 more
doaj   +1 more source

Neuroendocrine neoplasms of the small bowel and pancreas

, 2019
The traditionally promulgated perspectives of neuroendocrine neoplasms as rare, indolent tumours are blunt and have been outdated for the last two decades.
Frilling, Andrea, Baum, Richard P., Oberg, Kjell, Kidd, Mark,, Kidd, Mark, Frilling, Andrea,, Clift, Ashley Kieran, Toumpanakis, Christos,, Baum, Richard P, Bodei, Lisa, Baum, Richard P.,, Clift, Ashley K, Modlin, Irvin, Öberg, Kjell,, Toumpanakis, Christos, Clift, Ashley Kieran,, Modlin, Irvin M.,, Bodei, Lisa,, Modlin, Irvin M.   +18 more
core   +1 more source

New Onset of Fibromyalgia After Exposure to a Combat Environment: A Longitudinal Cohort Study

Arthritis Care &Research, EarlyView.
Objective Traumatic life events are hypothesized to be triggers for the onset of fibromyalgia. Posttraumatic stress disorder (PTSD) is a common comorbidity of fibromyalgia. However, limited prospective data are available on the development of fibromyalgia after exposure to high‐magnitude stress.
Jay B. Higgs, Willie J. Hale, Casey L. Straud, Jim Mintz, Stacey Young‐McCaughan, Kimberly D. Gomes, Chelsea J. Sterne, Katrina M. Lawrence‐Wolff, Alan J. Bartholomew, Kevin M. Kelly, Douglas M. Maurer, Catherine Vriend, Brett T. Litz, Douglas E. Williamson, Alan L. Peterson, for the STRONG STAR Consortium   +15 more
wiley   +1 more source

Achievement of complete in vitro spermatogenesis in testicular tissues from prepubertal mice exposed to mono- or polychemotherapy

Scientific Reports, 2022
The assessment of the impact of chemotherapies on in vitro spermatogenesis in experimental models is required before considering the application of this fertility restoration strategy to prepubertal boys who received these treatments before testicular ...
Marion Delessard, Laura Stalin, Aurélie Rives-Feraille, Laura Moutard, Justine Saulnier, Ludovic Dumont, Nathalie Rives, Christine Rondanino   +7 more
doaj   +1 more source

China Anti-Cancer Association guideline for diagnosis and treatment of neuroendocrine neoplasms (2025 edition) [PDF]

Neuroendocrine neoplasms (NENs) are a rare group of tumors that originated from peptidergic neurons and neuroendocrine cells, which has neuroendocrine differentiation characteristics and expresses neuroendocrine markers.
Society of Neuroendocrine Neoplasm of China Anti-Cancer Association
core   +1 more source

Cystic Hepatic Neuroendocrine Tumor: A Rare Entity.

, 2021
A 70-year-old man presented with unspecific abdominal symptoms and weight loss was referred for a sonographic examination. Sonography revealed 3 cystic hepatic masses in an otherwise unremarkable liver. Contrast-enhanced MRI of the liver was performed to
Afshar Oromieh, Ali, Obmann, Verena Carola, Haupt, Fabian, Huber, Adrian Thomas, Maurer, Martin   +4 more
core   +1 more source

A Brain‐Wide Atlas of Astrocytic Oxytocin Receptors Reveals a Glial Basis for Nucleus Accumbens Modulation of Affiliative Behavior

Advanced Science, EarlyView.
The cellular actors of oxytocin signaling are under intense scrutiny. A brain‐wide anatomical and functional analysis in mice and rats reveals widespread expression of oxytocin receptors in astrocytes. These receptors are functionally active and, in the nucleus accumbens, selectively regulate male social affiliation.
Clémence Denis, Stefan Stojilkovic, Kai‐Yi Wang, Cristina Márquez, Annabel C. Kleinwächter, Angel Baudon, Yuval Podpecan, Aurélia Ces, Mélanie Kremer, Isabelle Arnoux, Nathalie Rouach, Jemima Helen, Sophie Trender, Andreas Wallkum, Selina Wunsch, Franziska Schommer, Moritz C. Wimmer, Tim Schubert, Felix Franke, Jabir Aliyu Muhammad, Eva M. Eisemann, Ingrid Camila Possa‐Paranhos, Cassandra Baumann, Pierre‐Alexis Derrien, Quirin Krabichler, Cosmo Garcia, Henning Fröhlich, Matthew K. Kirchner, Valery Grinevich, Pascal Darbon, Javier E. Stern, Ferdinand Althammer, Alexandre Charlet   +32 more
wiley   +1 more source

Cowden Syndrome and Concomitant Pulmonary Neuroendocrine Tumor: A Presentation of Two Cases

Case Reports in Medicine, 2015
Cowden Syndrome is a rare autosomal dominantly inherited disorder. Patients with Cowden Syndrome are at increased risk of various benign and malignant neoplasms in breast, endometrium, thyroid, gastrointestinal tract, and genitourinary system ...
Seppo W. Langer, Lene Ringholm, Christine I. Dali, Rene Horsleben Petersen, Åse Krogh Rasmussen, Anne-Marie Gerdes, Birgitte Federspiel, Ulrich Peter Knigge   +7 more
doaj   +1 more source

Current Treatments and Controversies in Neuroendocrine Neoplasia

, 2022
Although advances in understanding the mutational and transcriptomic landscape of neuroendocrine tumors (NETs) have been made, a dearth of targetable biomarkers and unclear therapeutic pathways remain.
Bolduan, Felix, Wiedenmann, Bertram, Pavel, Marianne, Perren, Aurel   +3 more
core