Results 61 to 70 of about 278,007 (254)

Cowden Syndrome and Concomitant Pulmonary Neuroendocrine Tumor: A Presentation of Two Cases

Case Reports in Medicine, 2015
Cowden Syndrome is a rare autosomal dominantly inherited disorder. Patients with Cowden Syndrome are at increased risk of various benign and malignant neoplasms in breast, endometrium, thyroid, gastrointestinal tract, and genitourinary system ...
Seppo W. Langer, Lene Ringholm, Christine I. Dali, Rene Horsleben Petersen, Åse Krogh Rasmussen, Anne-Marie Gerdes, Birgitte Federspiel, Ulrich Peter Knigge   +7 more
doaj   +1 more source

P53, Somatostatin receptor 2a and Chromogranin A immunostaining as prognostic markers in high grade gastroenteropancreatic neuroendocrine neoplasms

BMC Cancer, 2020
Background High grade gastroenteropancreatic (GEP) neuroendocrine neoplasms (NEN) with a Ki67 proliferation index > 20%, include well-differentiated tumours grade 3 (NET G3) and poorly differentiated (PD) neuroendocrine carcinomas (NEC).
Kirstine Nielsen, Tina Binderup, Seppo W. Langer, Andreas Kjaer, Pauline Knigge, Veronica Grøndahl, Linea Melchior, Birgitte Federspiel, Ulrich Knigge   +8 more
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

S005-GNRH-1 VE GNRH-2’NIN PERİFERAL LENFOSİT PROLİFERASYONU VE IL-2 RESEPTÖR (IL-2R) EKSPRESYONU ÜZERİNE FARKLI ETKİLER

Endocrinology Research and Practice, 2022
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Fatih Tanrıverdi, Youli Hu, D. Gonzalez Martinez, Pierre M.G. Bouloux, Fahrettin Keleştimur   +4 more
doaj   +4 more sources

China Anti-Cancer Association guideline for diagnosis and treatment of neuroendocrine neoplasms (2025 edition) [PDF]

Neuroendocrine neoplasms (NENs) are a rare group of tumors that originated from peptidergic neurons and neuroendocrine cells, which has neuroendocrine differentiation characteristics and expresses neuroendocrine markers.
Society of Neuroendocrine Neoplasm of China Anti-Cancer Association
core   +2 more sources

Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang, Dongxu Zhang, Dongyuan Liu, Da Lin, Hao Wang   +4 more
wiley   +1 more source

Metastatic neuroendocrine carcinoma in inguinal region complicated with membranous nephropathy: a case report

Discover Oncology
Neuroendocrine neoplasms (NENs) are rare, malignant tumors characterized by variable incidence rates globally, with an overall trend of increasing frequency. The gastrointestinal tract and lungs are the most common primary sites for NENs. Between 11% and
Xinyun Qiang, Jieyu Lu, Mujie Ye, Ruitong Xu, Qiyun Tang   +4 more
doaj   +1 more source

Single‐Cell Dissection of Therapy‐Induced Remodeling Uncovers a Fibroblast‐Driven Immunosuppressive Niche and Targetable Vulnerabilities in Lethal Prostate Cancer

Advanced Science, EarlyView.
Single‐cell longitudinal profiling reveals that androgen‐deprivation therapy induces a DPT+ fibroblast‐complement axis that suppresses macrophage inflammation and drives CD8+ T cell exhaustion in prostate cancer. Concurrently, resistant epithelial subpopulations persist and engage TSPAN1‐ and NRXN1‐mediated programs promoting CRPC and neuroendocrine ...
Yang Chen, Dandan Dong, Jinling Liao, Naikai Liao, Mengqi Liu, Qin Zhang, Siting Chen, Qi Liu, Ying Lu, Tianyu Li, Chunlin Zou, Qiong Song, Qiuyan Wang, Jian Liang, Qiji Xie, Chengyang Li, Mengyun Wang, Jiwen Cheng, Zengnan Mo, Gong‐Hong Wei   +19 more
wiley   +1 more source

Transient sex-related changes in the mice hypothalamo–pituitary–adrenal (HPA) axis during the acute phase of the inflammatory process

Mediators of Inflammation, 1993
The potential role of endogenous sex hormones in regulating hypothalamo–pituitary–adrenal (HPA) axis function was investigated after a single injection of endotoxin in adult (8 week old) BALB/c mice of both sexes.
T. Daneva, E. Spinedi, R. Hadid, M.-C. Jacquier, M. Giacomini, R. C. Gaillard   +5 more
doaj   +1 more source

Pharmacological Management of Gastrointestinal Neuroendocrine Tumors

, 2022
Gastrointestinal Neuroendocrine tumors are a rare diverse group of tumors arising from the diffuse neuroendocrine system. In recent times the incidence and prevalence of these tumors have increased which has led to further investigations on the treatment
Lawrence, Janet
core