Results 71 to 80 of about 369,175 (312)

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Achievement of complete in vitro spermatogenesis in testicular tissues from prepubertal mice exposed to mono- or polychemotherapy

Scientific Reports, 2022
The assessment of the impact of chemotherapies on in vitro spermatogenesis in experimental models is required before considering the application of this fertility restoration strategy to prepubertal boys who received these treatments before testicular ...
Marion Delessard, Laura Stalin, Aurélie Rives-Feraille, Laura Moutard, Justine Saulnier, Ludovic Dumont, Nathalie Rives, Christine Rondanino   +7 more
doaj   +1 more source

Stress induced polarization of immune-neuroendocrine phenotypes in Gallus gallus [PDF]

, 2017
Immune-neuroendocrine phenotypes (INPs) stand for population subgroups differing in immune-neuroendocrine interactions. While mammalian INPs have been characterized thoroughly in rats and humans, avian INPs were only recently described in Coturnix ...
A Fallahsharoudi, A Wirén, AA Cohen, AF Soleimani, B Eklund, BG Miner, CC Rittschof, CL Butts, D Huss, D Renaudeau, E Ottaviani, EM Sternberg, EM Sternberg, FN Nazar, FN Nazar, FN Nazar, FS Dhabhar, FS Dhabhar, G Fusco, GE Demas, H Besedovsky, HL Carson, HW Cheng, IJ Elenkov, IJ Elenkov, IJ Elenkov, J Kaufman, JM Fair, JM Koolhaas, K LoGiudice, KA Schmidt, KM Dlugosch, L Calandreau, L Lara, LB Martin, M Ericsson, M Hau, M Jafarian-Tehrani, MA Cheema, MF Flajnik, MH Kogut, ML Roberts, MM Mashaly, NT Ashley, P Kaiser, P Zelazowski, PJ Most van der, R Adriaansen-Tennekes, R Wei, RH Marin, RJ Blanchard, RL Dennis, S Davies, S Puvadolpirod, S Shini, T Cornetto, T Maruyama, TJ DeWitt, WB Gross, WJ Kuenzel, WM Rauw, YH Hong   +61 more
core   +1 more source

New Onset of Fibromyalgia After Exposure to a Combat Environment: A Longitudinal Cohort Study

Arthritis Care &Research, EarlyView.
Objective Traumatic life events are hypothesized to be triggers for the onset of fibromyalgia. Posttraumatic stress disorder (PTSD) is a common comorbidity of fibromyalgia. However, limited prospective data are available on the development of fibromyalgia after exposure to high‐magnitude stress.
Jay B. Higgs, Willie J. Hale, Casey L. Straud, Jim Mintz, Stacey Young‐McCaughan, Kimberly D. Gomes, Chelsea J. Sterne, Katrina M. Lawrence‐Wolff, Alan J. Bartholomew, Kevin M. Kelly, Douglas M. Maurer, Catherine Vriend, Brett T. Litz, Douglas E. Williamson, Alan L. Peterson, for the STRONG STAR Consortium   +15 more
wiley   +1 more source

P53, Somatostatin receptor 2a and Chromogranin A immunostaining as prognostic markers in high grade gastroenteropancreatic neuroendocrine neoplasms

BMC Cancer, 2020
Background High grade gastroenteropancreatic (GEP) neuroendocrine neoplasms (NEN) with a Ki67 proliferation index > 20%, include well-differentiated tumours grade 3 (NET G3) and poorly differentiated (PD) neuroendocrine carcinomas (NEC).
Kirstine Nielsen, Tina Binderup, Seppo W. Langer, Andreas Kjaer, Pauline Knigge, Veronica Grøndahl, Linea Melchior, Birgitte Federspiel, Ulrich Knigge   +8 more
doaj   +1 more source

Somatostatin Analogues in the Treatment of Neuroendocrine Tumors: Past, Present and Future [PDF]

, 2019
In recent decades, the incidence of neuroendocrine tumors (NETs) has steadily increased. Due to the slow-growing nature of these tumors and the lack of early symptoms, most cases are diagnosed at advanced stages, when curative treatment options are no ...
Amthauer, Holger, Jann, Henning, Kayser, Antonin, Roderburg, Christoph, Stueven, Anna Kathrin, Tacke, Frank, Wetz, Christoph, Wiedenmann, Bertram, Wree, Alexander   +8 more
core   +1 more source

Aptamer‐Based Delivery Systems for VEGF and NGF Modulation in Ocular Therapies

Advanced Healthcare Materials, EarlyView.
Aptamer‐based delivery systems targeting NGF and VEGF hold significant potential for precise and sustained treatment of complex diseases affecting both the anterior and posterior segments of the eye. This review critically summarizes current strategies for NGF and VEGF delivery as well as VEGF sequestration, providing a clinical perspective on how ...
Nadine Best, Gizem Karabiyik, Gerd Geerling, Sarah Barbara Zwingelberg, Gregor Lang, Martin Humenik   +5 more
wiley   +1 more source

Enhanced at puberty 1 (EAP1) is a new transcriptional regulator of the female neuroendocrine reproductive axis [PDF]

, 2007
The initiation of mammalian puberty and the maintenance of female reproductive cycles are events controlled by hypothalamic neurons that secrete the decapeptide gonadotropin-releasing hormone (GnRH).
Sabine Heger, Claudio Mastronardi, Gregory A. Dissen, Alejandro Lomniczi, Ricardo Cabrera, Christian L. Roth, Heike Jung, Francesco Galimi, Wolfgang Sippell, Sergio R. Ojeda, Ojeda, Terasawa, Dungan, DeFazio, Krewson, Seminara, Palmert, de Vries, Ojeda, Davidson, Basso, Rampazzo, Sutton, Martin, Bhanot, Ebling, Morris-Desbois, Burkhard, Sauring, Freemont, Waterman, Bridge, Tiscornia, Sledz, Simerly, Farooqi, Ahima, Shimono, Childs, Treacy, Ma, Ojeda, Kimura, Lee, Mastronardi, Ojeda, Watanabe, Nelson, Prevot, Dissen, Dissen, Shahab, Miyagishi, Singer, Chen, Naldini, Kootstra   +56 more
core   +1 more source

A Biomarker‐Driven Ovary–Endometrium Organ‐on‐a‐Chip Mimicking 3D Multicellular Complexity and Menstrual Cyclicity for Predicting Reproductive Toxicity

Advanced Science, EarlyView.
We present a dual‐organ, biomarker‐integrated ovaryendometrium organ‐on‐a‐chip that recapitulates 3D tissue complexity, menstrual cycle dynamics, and hormonal crosstalk. This platform enables real‐time, cell‐typespecific fluorescent readouts of reproductive toxicity using ANGPTL4 and SERPINB2 as early‐response reporters.
Soo‐Rim Kim, Eun‐kyung Min, Choon‐Mi Lee, Chan Hum Park, Byung‐Chul Oh, YunJae Jung, In‐Sun Hong   +6 more
wiley   +1 more source

S005-GNRH-1 VE GNRH-2’NIN PERİFERAL LENFOSİT PROLİFERASYONU VE IL-2 RESEPTÖR (IL-2R) EKSPRESYONU ÜZERİNE FARKLI ETKİLER

Endocrinology Research and Practice, 2022
-
Fatih Tanrıverdi, Youli Hu, D. Gonzalez Martinez, Pierre M.G. Bouloux, Fahrettin Keleştimur   +4 more
doaj   +4 more sources