Results 101 to 110 of about 1,553,841 (335)
Advanced Science, EarlyView.Our study reveals a novel mechanism of a positive regulatory circuit between Cav1.2 and H3K27ac for pancreatic neuroendocrine neoplasms (pNENs) progression. Cav1.2 is identified as a crucial target for promoting disease progression and correlates with malignant behaviors, which are remarkably inhibited by the administration of calcium channel blockers (
Yangyinhui Yu +12 more
wiley +1 more source
Fine needle aspiration cytology of hepatic metastases of neuroendocrine tumors: A 20‐year retrospective, single institutional study [PDF]
, 2017 Background Fine needle aspiration (FNA) is considered an excellent technique for documenting metastatic neuroendocrine tumors (NETs). This study aims to evaluate the accuracy of FNA in diagnosing metastatic NETs to the liver and determining the grade ...
Cramer, Harvey +3 more
core +1 more source
GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy
Advanced Science, EarlyView.Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu +11 more
wiley +1 more source
PLoS ONE, 2019 This study aimed to identify the trends in the incidence of thymic cancer, i.e., thymoma, thymic carcinoma, and thymic neuroendocrine tumor, in the United States.
Chun-Hsiang Hsu +5 more
semanticscholar +1 more source
Annals of Gastroenterological Surgery, EarlyView.ABSTRACT Background The annual number of pancreatoduodenectomies (PDs) in the United States has increased over the past decade, but the facility types driving this growth and whether outcomes have improved remain unclear. We aimed to identify characteristics of facilities with increasing PD volumes and assess national trends in centralization ...
Koichi Tomita, Naruhiko Ikoma
wiley +1 more source
FGFR2 amplification in colorectal adenocarcinoma [PDF]
, 2017 FGFR2 is recurrently amplified in 5% of gastric cancers and 1%–4% of breast cancers; however, this molecular alteration has never been reported in a primary colorectal cancer specimen.
Carter, Jamal H +6 more
core +2 more sources
Advanced esophageal neuroendocrine carcinoma
Revista Española de Enfermedades DigestivasCase report of an advanced esophageal neuroendocrine carcinoma with hepatic metastasis.
Fernando, Muñoz Agel +1 more
openaire +2 more sources
Annals of Gastroenterological Surgery, EarlyView.ABSTRACT Background/Objectives Postoperative complications following pancreaticoduodenectomy (PD) remain high, particularly in patients with soft pancreatic texture. Abdominal aortic calcification volume (AACV), a surrogate marker of systemic arteriosclerosis, has been associated with increased surgical risk in lower gastrointestinal procedures ...
Masaki Horiuchi +9 more
wiley +1 more source
Otolaryngology Case Reports, 2019 Introduction: Paucity of reported cases and lack of significant follow-up preclude definitive statements regarding the prognosis of sinonasal non-small cell neuroendocrine carcinoma (NSNEC). The validity of histologic grading as a prognostic indicator in
Shivesh Maharaj, Farzana Mahomed
doaj +1 more source
Meta-analysis of stomatitis in clinical studies of everolimus: incidence and relationship with efficacy. [PDF]
, 2016 BackgroundEverolimus, an oral mammalian target of rapamycin (mTOR) inhibitor, is used to treat solid tumors and tuberous sclerosis complex (TSC). Stomatitis, an inflammation of the mucous membranes of the mouth, is a common adverse event associated with ...
Anak, O +10 more
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