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Neuroendocrine differentiation in prostatic carcinoma [PDF]
Prostate, 1999 Information is presented on prostatic neuroendocrine cells and neuroendocrine differentiation in prostatic carcinoma. The prognostic and therapeutic implications of neuroendocrine differentiation in prostatic carcinoma are reviewed.Data are presented that support the intriguing link between neuroendocrine differentiation, tumor progression, and ...
Per-Anders Abrahamsson, P A Abrahamsson
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Nephroblastoma with Neuroendocrine Differentiation
Tumori Journal, 1989A nephroblastoma (Wilms' tumor) with morphological, histochemical, immunohistochemical and ultrastructural evidence of neuroendocrine differentiation is described. Whereas areas of neural differentiation and occasional argyrophilic cells in cases of Wilms' tumor have been previously reported, the unique characteristic in this case was the extent of the
A, Orazi +4 more
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Prostate Cancer and Neuroendocrine Differentiation
International Urology and Nephrology, 1999A retrospective study was conducted in 41 patients with adenocarcinoma of the prostate to investigate the correlation between pathological stage, Gleason score and neuroendocrine differentiation in order to evaluate the prognostic significance of neuroendocrine differentiation. Patients' ages ranged from 50 to 84 (mean 69.1) years. Clinical staging was
ÇELİK, BÜLENT +5 more
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NEUROENDOCRINE DIFFERENTIATION IN LUNG CANCER
The Journal of Pathology, 1997The human lung has a resident population of neuroendocrine (NE) cells. These are characterised by the presence of neurosecretory granules and by a number of histochemical and immunocytochemical reactions. NE differentiation is a defining feature of classical and atypical carcinoid tumours and is seen in most small cell lung cancers (SCLC).
F A, Carey, V E, Save
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Neuroendocrine Differentiation in Prostatic Carcinoma
Scandinavian Journal of Urology and Nephrology, 2003Knowledge and understanding of the pathophysiology of prostate cancer remain rudimentary. However, insight into epigenetic events and cellular interactions between cancer cells and the surrounding milieu has recently opened up a broader concept of cancer development. Throughout the entire process of prostate cancer aetiology, progression and metastasis,
Jens, Hansson, Per-Anders, Abrahamsson
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Neuroendocrine Differentiation in Breast Lesions
Pathology - Research and Practice, 1988A review of neuroendocrine features in breast carcinomas is presented and markers for neuroendocrine cells are discussed. Immunostaining for neuron specific enolase is the best screening marker for neuroendocrine cells in breast carcinomas, but immunoreactivity for hormones is not present in all neuron specific enolase (NSE) positive cases.
J M, Nesland +3 more
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Neuroendocrine differentiation in prostatic carcinoma
Human Pathology, 1987Specimens from 53 cases of prostatic carcinoma obtained during total prostatectomy or transurethral resection of prostate were analyzed for neuroendocrine differentiation with immunocytochemical tests for serotonin, neuron-specific enolase, and chromogranin as well as with the Churukian-Schenk argyrophil reaction. Forty-seven per cent (25 of 53) of the
P A, di Sant'Agnese, K L, de Mesy Jensen
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Neuroendocrine Differentiation, Neuropeptides, and Neprilysin
American Journal of Respiratory Cell and Molecular Biology, 1999Pulmonary neuroendocrine cells exhibit highly specialized differentiation with a neurosecretory phenotype and significant bioactive peptide hormone content. In addition to these functions, pulmonary neuroendocrine cells have been demonstrated to act as chemoreceptors for hypoxia (1).
A J, Cohen, Y E, Miller
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Virchows Archiv
Gastroenteropancreatic well-differentiated neuroendocrine tumors (NETs) exhibit markedly different behavior and responses to therapy compared to poorly-differentiated neuroendocrine carcinomas (NECs). However, in certain NETs-particularly grade 3 (Ki-67 > 20%) and the more recently recognized subgroup of G2b (Ki-67 of 10%- ≤ 20%)-often display ...
Dorukhan Bahceci +2 more
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Gastroenteropancreatic well-differentiated neuroendocrine tumors (NETs) exhibit markedly different behavior and responses to therapy compared to poorly-differentiated neuroendocrine carcinomas (NECs). However, in certain NETs-particularly grade 3 (Ki-67 > 20%) and the more recently recognized subgroup of G2b (Ki-67 of 10%- ≤ 20%)-often display ...
Dorukhan Bahceci +2 more
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Secretagogin Is a Novel Marker for Neuroendocrine Differentiation
Neuroendocrinology, 2005Our previous microarray-based studies identified secretagogin to be highly expressed in normal colon mucosa compared to basal expression in colon adenocarcinomas. The aim of this study was to analyze the differential expression of secretagogin in normal mucosa, adenocarcinomas, and neuroendocrine tumors.
Birkenkamp-Demtröder, Karin +8 more
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