Results 21 to 30 of about 25,703 (229)

Isolated plexiform neurofibroma over left palm: A case report and review of literature

Indian Journal of Dermatology, 2013
Plexiform neurofibroma is common over the branches of trigeminal and cervical nerves over the face. Plexiform neurofibroma over palm is rare and affects the individuals with fine motor functions of hand.
Mohan H Kudur, Manjunath Hulmani
doaj   +1 more source

Cdkn2a (Arf) loss drives NF1-associated atypical neurofibroma and malignant transformation.

Human Molecular Genetics, 2019
Plexiform neurofibroma (PN) tumors are a hallmark manifestation of neurofibromatosis type 1 (NF1) that arise in the Schwann cell (SC) lineage. NF1 is a common heritable cancer predisposition syndrome caused by germline mutations in the NF1 tumor ...
Steven D. Rhodes, Yongzheng He, A. Smith, Li Jiang, Qingbo Lu, Julie A. Mund, Xiaohong Li, Waylan K Bessler, Shaomin Qian, William Dyer, G. Sandusky, A. Horvai, Amy E. Armstrong, D. Clapp   +13 more
semanticscholar   +1 more source

Lumbar plexiform neurofibroma, short stature, and kyphoscoliosis in neurofibromatosis-1: A Rare entity

Sahel Medical Journal, 2019
The incidence of neurofibromatosis (NF), comprising NF-1 and NF-2, seems to be rising in Nigeria. The features of NF-1 have not been completely identified in the country.
Ernest Ndukaife Anyabolu
doaj   +1 more source

A phase 2 study of trametinib for patients with pediatric glioma or plexiform neurofibroma with refractory tumor and activation of the MAPK/ERK pathway: TRAM-01

BMC Cancer, 2019
Pediatric low-grade gliomas (PLGG) are the most frequent brain tumors in children. Up to 50% will be refractory to conventional chemotherapy. It is now known that the majority of PLGG have activation of the MAPK/ERK pathway.
S. Perreault, Valérie Larouche, U. Tabori, Cynthia Hawkin, S. Lippé, B. Ellezam, J. Décarie, Y. Théorêt, Marie-Élaine Métras, S. Sultan, Édith Cantin, Marie-Ève Routhier, M. Caru, G. Legault, E. Bouffet, L. Lafay-Cousin, J. Hukin, C. Erker, N. Jabado   +18 more
semanticscholar   +1 more source

A molecular basis for neurofibroma-associated skeletal manifestations in NF1

Genetics in Medicine, 2020
Purpose Plexiform neurofibromas (pNF) develop in children with neurofibromatosis type 1 (NF1) and can be associated with several skeletal comorbidities.
Yun Ma, A. Gross, E. Dombi, A. Pemov, Kwangmin Choi, K. Chaney, Steven D. Rhodes, Steven P. Angus, N. Sciaky, D. Clapp, N. Ratner, B. Widemann, J. Rios, Florent Elefteriou   +13 more
semanticscholar   +1 more source

Neurofibroma plexiforme gigante da região lombar com transformação hemorrágica – Relato de caso

Brazilian Neurosurgery, 2013
A neurofibromatose tipo 1 é uma facomatose que apresenta, entre outras características, tumores oriundos da bainha dos nervos como o neurofibroma plexiforme. Neste artigo é relatado o caso de um paciente que sofreu transformação hemorrágica espontânea de
Mayara Dalila Cardoso de Lima, Washington Luiz de Oliveira, Carlos Elizeu Barcelos, Sergio Luiz Sprengel, João Cândido Araújo   +4 more
doaj   +1 more source

Management of cutaneous neurofibroma: current therapy and future directions

Neuro-Oncology Advances, 2019
Neurofibromatosis type 1 (NF1) is a life-long neurocutaneous disorder characterized by a predisposition to tumor development, including cutaneous neurofibroma (cNF), the hallmark of the disease.
B. Chamseddin, L. Le
semanticscholar   +1 more source

Cellular Neurofibroma with Atypia Mimics Sarcoma: Report of a Case with Immunohistochemical Staining Pattern Analysis and Literature Review

Kaohsiung Journal of Medical Sciences, 2006
A case of two sporadic cellular neurofibromas with atypia and one widespread hyalinization neurofibroma of the lumbar spine in a 51-year-old man without evidence of neurofibromatosis-1 is reported. Cellular neurofibroma with atypia is an unusual variant.
Shih-Wen Hu, Shiuh-Lin Hwang, Wei-Chen Lin, Kun-Bow Tsai   +3 more
doaj   +1 more source

After Nf1 loss in Schwann cells, inflammation drives neurofibroma formation

Neuro-Oncology Advances, 2019
Plexiform neurofibromas (PNF) are peripheral nerve tumors caused by bi-allelic loss of NF1 in the Schwann cell (SC) lineage. PNF are common in individuals with Neurofibromatosis type I (NF1) and can cause significant patient morbidity, spurring research ...
Jonathan S. Fletcher, Jay Pundavela, N. Ratner   +2 more
semanticscholar   +1 more source

Pigmented neurofibroma of the skin

Archives of Medicine and Health Sciences, 2015
Pigmented neurofibroma is a rare variant of neurofibroma commonly associated with neurofibromatosis 1 of diffuse type. Histopathologic examination is essential to differentiate it from other pigmented lesions.
Hemalata Mahantappa, Suguna Belur Venugopal, Swati Agarwal   +2 more
doaj   +1 more source