Results 31 to 40 of about 1,400 (148)

Trametinib in Adults with Neurofibromatosis Type 1‐Related Symptomatic Plexiform Neurofibromas

Annals of Neurology, Volume 99, Issue 1, Page 73-83, January 2026.
Objective Mitogen‐activated protein kinase kinase inhibitors have shown promising results in treatment of plexiform neurofibromas in neurofibromatosis type 1 patients, but data in adults are limited. The aim of this phase 2 study was to investigate the efficacy and safety of trametinib in adults with neurofibromatosis type 1.
D. Christine Noordhoek, David F. Hanff, Pim J. French, Sarah A. van Dijk, Erik A.C. Wiemer, Olivier C. Manintveld, Martin J. van den Bent, Walter Taal   +7 more
wiley   +1 more source

Case for diagnosis [PDF]

, 2011
O termo úlcera de Marjolin é usado para designar a transformação maligna que se origina na pele cronicamente lesada. Trata-se de neoplasia mais agressiva do que aquelas não relacionadas com cicatriz e, frequentemente, é subdiagnosticada ou tratada de ...
ALMEIDA, José Roberto Paes de, DINATO, Marcelo Mattos e, DINATO, Sandra Lopes Mattos e, NÓVOA, Estela Gemha de, ROMITI, Ney   +4 more
core   +3 more sources

Nanodroplet‐Array‐Plattform zur integrierten Synthese und Screening von MEK Inhibitoren: Ein miniaturisierter Ansatz für die frühe Pharmaforschung

Angewandte Chemie, Volume 137, Issue 48, November 24, 2025.
Wir präsentieren eine Nanodroplet‐Array‐Plattform, die die Integration von Festphasensynthese, MALDI‐MS‐Analyse und zellbasiertem Screening von 325 potenziellen MEK‐Inhibitoren (Mitogen‐aktivierte‐Proteinkinase‐Kinase) in Nanoliter‐Volumina ermöglicht.
Maximilian Seifermann, Julius Höpfner, Liana Bauer, Divya Varadharajan, Stefan Schmidt, Björn Fröhlich, Benjamin Wellenhofer, Charlotte Luchena, Carsten Hopf, Anna A. Popova, Pavel A. Levkin   +10 more
wiley   +1 more source

Aetiopathogenesis of infantile epileptic spasms syndrome and mechanisms of action of adrenocorticotrophin hormone/corticosteroids in children: A scoping review

Developmental Medicine &Child Neurology, Volume 67, Issue 8, Page 1004-1025, August 2025.
Why does infantile epileptic spasms syndrome (IESS) occur with a variety of underlying conditions and why does it respond to adrenocorticotrophin hormone (ACTH)/corticosteroids? Our scoping review summarizes five hypotheses from the literature: gene/epigenetic regulation, stress/HPA axis activation, neuroinflammation/immune function, altered neuronal ...
Emily A. Innes, Velda X. Han, Shrujna Patel, Michelle A. Farrar, Deepak Gill, Shekeeb S. Mohammad, Russell C. Dale   +6 more
wiley   +1 more source

Multiple endocrine neoplasia [PDF]

, 2007
The knowledge of genetics has increased in recent years and has led to important changes in management of hereditary diseases. Multiple endocrine neoplasia is characterized by the occurrence of benign or malign tumours involving two or more endocrine ...
Guimarães, J
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Diagnostic Importance of Cutaneous Manifestations of Neurofibromatosis—A Systematic Review

Neurology and Clinical Neuroscience, Volume 13, Issue 3, Page 165-173, May 2025.
ABSTRACT A class of hereditary diseases known as neurofibromatoses results in tumor growth on tissue from nerves. The spinal cord, nerves, and brain are among the parts of the nervous framework where these tumors can form. Similar to other genetic disorders, neurofibromatosis discloses complicated phenotypes, exhibiting varying benign and malignant ...
Hina Aslam, Inshal Jawed, Ali Farhan, Vikash Karmani, Agha Muhammad Wali Mirza, Farah Alam, Hina Khan, Abdul Haseeb, Mohammad Omer Alam, Javed Iqbal, Brijesh Sathian, Abu Huraira Bin Gulzar   +11 more
wiley   +1 more source

Lamotrigine for cognitive deficits associated with neurofibromatosis type 1: A phase II randomized placebo‐controlled trial

Developmental Medicine &Child Neurology, Volume 67, Issue 4, Page 537-549, April 2025.
Plain language summary: https://onlinelibrary.wiley.com/doi/10.1111/dmcn.16157 In this double‐blind, placebo‐controlled, randomized clinical trial, 31 adolescents with neurofibromatosis type 1 (NF1) were enrolled to test the effects of lamotrigine on cognitive functioning.
Myrthe J. Ottenhoff, Sabine E. Mous, Jesminne Castricum, André B. Rietman, Rianne Oostenbrink, Thijs van der Vaart, Joke H. M. Tulen, Alba Parra, Federico J. Ramos, Eric Legius, Henriette A. Moll, Ype Elgersma, Marie‐Claire Y. de Wit, ENCORE Expertise Center for NF1, Walter Taal, Sarah van Dijk, Laura de Graaff, Yvette van Ierland, Margreethe van Vliet, Jeroen Legerstee, Pieter de Nijs, Maarten van Schijndel   +21 more
wiley   +1 more source

CD95 maintains stem cell-like and non-classical EMT programs in primary human glioblastoma cells [PDF]

, 2016
Glioblastoma (GBM) is one of the most aggressive types of cancer with limited therapeutic options and unfavorable prognosis. Stemness and non-classical epithelial-to-mesenchymal transition (ncEMT) features underlie the switch from normal to neoplastic ...
Chen, S., Cirovic, B., Drachsler, M., Gieffers, C., Kleber, S., Martin-Villalba, A., Mateos, A., Mohr, N., Mueller, W., Sykora, J., Synowitz, M., Tuettenberg, J., Volk, K., Wirtz, C. R.   +13 more
core   +2 more sources

An Unexplored Diversity for Adaptation of Germination to High Temperatures in Brassica Species

Evolutionary Applications, Volume 18, Issue 3, March 2025.
ABSTRACT Elevated temperatures inhibit the germination of a concerning number of crop species. One strategy to mitigate the impact of warming temperatures is to identify and introgress adaptive genes into elite germplasm. Diversity must be sought in wild populations, coupled with an understanding of the complex pattern of adaptation across a broad ...
M. Tiret, M.‐H. Wagner, L. Gay, E. Chenel, A. Dupont, C. Falentin, L. Maillet, F. Gavory, K. Labadie, S. Ducournau, A.‐M. Chèvre   +10 more
wiley   +1 more source

Le gradient entre la pression pulmonaire artérielle diastolique et la pression pulmonaire d'occlusion est important dans l'évaluation des hypertensions pulmonaires post- capillaires [PDF]

, 2012
Les hypertensions pulmonaires post-capillaires sont définies par une pression artérielle moyenne (PAPm) ≥ 25mmHg et une pression pulmonaire d'occlusion (PAPO) > 15mmHg.
Stettler, S.
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