Results 1 to 10 of about 50,654 (188)

Neurofilament proteins as a potential biomarker in chemotherapy-induced polyneuropathy [PDF]

JCI Insight, 2022
BACKGROUND Paclitaxel chemotherapy frequently induces dose-limiting sensory axonal polyneuropathy. Given that sensory symptoms are challenging to assess objectively in clinical practice, an easily accessible biomarker for chemotherapy-induced ...
Petra Huehnchen, Christian Schinke, Nikola Bangemann, Adam D. Dordevic, Johannes Kern, Smilla K. Maierhof, Lois Hew, Luca Nolte, Peter Körtvelyessy, Jens C. Göpfert, Klemens Ruprecht, Christopher J. Somps, Jens-Uwe Blohmer, Jalid Sehouli, Matthias Endres, Wolfgang Boehmerle   +15 more
doaj   +2 more sources

Neurofilament Proteins as Biomarkers to Monitor Neurological Diseases and the Efficacy of Therapies [PDF]

Frontiers in Neuroscience, 2021
Biomarkers of neurodegeneration and neuronal injury have the potential to improve diagnostic accuracy, disease monitoring, prognosis, and measure treatment efficacy.
Aidong Yuan, Aidong Yuan, Ralph A. Nixon, Ralph A. Nixon, Ralph A. Nixon   +4 more
doaj   +2 more sources

The CRL3^gigaxonin ubiquitin ligase-USP15 pathway governs the destruction of neurofilament proteins. [PDF]

Proc Natl Acad Sci U S A, 2023
Park HM, Le L, Nguyen TT, Nam KH, Ordureau A, Lee JE, Nguyen TV.   +6 more
europepmc   +3 more sources

A Quantitative Systems Pharmacology Model That Describes Neurofilament Light Dynamics During Alzheimer's Disease Progression [PDF]

CPT: Pharmacometrics & Systems Pharmacology
Neurofilament proteins are important constituents of neuronal cytoskeleton, along with microtubules. An increased concentration of neurofilament light (NfL) protein in cerebrospinal fluid (CSF) and plasma is considered a potential biomarker of axonal ...
Polina Maliukova, Tatiana Karelina
doaj   +2 more sources

Humoral response to neurofilaments and dipeptide repeats in ALS progression

Annals of Clinical and Translational Neurology, 2021
Objective To appraise the utility as biomarkers of blood antibodies and immune complexes to neurofilaments and dipeptide repeat proteins, the products of translation of the most common genetic mutation in amyotrophic lateral sclerosis (ALS).
Fabiola Puentes, Vittoria Lombardi, Ching‐Hua Lu, Ozlem Yildiz, Pietro Fratta, Adrian Isaacs, Yoana Bobeva, Joanne Wuu, ALS Biomarker Consortium, CReATe Consortium, Michael Benatar, Andrea Malaspina   +11 more
doaj   +1 more source

The altered expression of cytoskeletal and synaptic remodeling proteins during epilepsy

Open Life Sciences, 2023
The cytoskeleton plays an important role in epilepsy; however, the mechanism is unknown. Therefore, this study aimed to reveal the mechanism of cytoskeletal proteins in epilepsy by investigating the expression of cytoskeletal proteins and synaptophysin ...
Xin Yanbao, Lin Guojiao, Hua Tianbao, Liang Jianmin, Sun Tianmeng, Wu Xuemei   +5 more
doaj   +1 more source

Plasma β‐synuclein, GFAP, and neurofilaments in patients with malignant gliomas undergoing surgical and adjuvant therapy

Annals of Clinical and Translational Neurology, 2023
We analyzed the longitudinal concentrations and prognostic roles of plasma β‐synuclein (β‐syn), glial fibrillary acidic protein (GFAP), and neurofilament proteins (NfL and NfH) in 33 patients with malignant gliomas, who underwent surgical and adjuvant ...
Samir Abu‐Rumeileh, Lorenzo Barba, Matthias Bache, Steffen Halbgebauer, Patrick Oeckl, Petra Steinacker, Antje Güttler, Jacqueline Keßler, Jörg Illert, Christian Strauss, Dirk Vordermark, Markus Otto   +11 more
doaj   +1 more source

(HIIT-The Track) High-Intensity Interval Training for People with Parkinson’s Disease: Individual Response Patterns of (Non-)Motor Symptoms and Blood-Based Biomarkers—A Crossover Single-Case Experimental Design

Brain Sciences, 2023
Introduction: Physical exercise is receiving increasing interest as an augmentative non-pharmacological intervention in Parkinson’s disease (PD). This pilot study primarily aimed to quantify individual response patterns of motor symptoms to alternating ...
Elvira S. Amaral Gomes, Odile A. Van den Heuvel, Marc B. Rietberg, Vincent De Groot, Mark A. Hirsch, Wilma D. J. Van de Berg, Richard T. Jaspers, Chris Vriend, Tim Vanbellingen, Erwin E. H. Van Wegen   +9 more
doaj   +1 more source

Research progression of neurofilament light chain in the diagnosis and differential diagnosis of Parkinson's disease

Chinese Journal of Contemporary Neurology and Neurosurgery, 2022
Parkinson's disease (PD) is a common neurodegenerative disease and the disease burden is increasing. Neurofilament light chain (NfL) is a neuronal cytoplasmic protein highly expressed in large calibre myelinated axons which may serve as a biomarker for ...
YIN Wei⁃fang, REN Hui, YANG Xing⁃long   +2 more
doaj   +1 more source

Inhibition of neurite outgrowth in differentiating mouse N2a neuroblastoma cells by phenyl saligenin phosphate: Effects on MAP kinase (ERK 1/2) activation, neurofilament heavy chain phosphorylation and neuropathy target esterase activity [PDF]

, 2006
Sub-lethal concentrations of the organophosphate phenyl saligenin phosphate (PSP) inhibited the outgrowth of axon-like processes in differentiating mouse N2a neuroblastoma cells (IC50 2.5 μM).
Abou-Donia, Abou-Donia, Alan J. Hargreaves, Barber, Barber, Brunet, Casida, Chambers, Denizot, Ehrich, El-Fawal, Eto, Flaskos, Flaskos, Forshaw, Fowler, Glynn, Glynn, Gupta, Hatch, Henschler, Ian C. Coutts, James, Jensen, John Flaskos, Johnson, Johnson, Johnson, Jortner, Jortner, Keilbaugh, Laemmli, Lee, Li, Lowry, Magdalini Sachana, Mary Bountouri, Maxine J. Fowler, Nixon, Nomeir, Nomeir, Nostrandt, Nostrandt, Paul Glynn, Perron, Rosenstock, Schmuck, Sharma, Song, Suwita, Towbin, Van Teinhoven, Veeranna, Veronesi, W. Graham McLean, Wayne Harris, Zhao   +56 more
core   +1 more source