Results 161 to 170 of about 50,787 (316)

Upregulation of sphingomyelin and ABCA8 in response to TDP‐43 pathology in amyotrophic lateral sclerosis brain

Brain Pathology, EarlyView.
Increases in sphingomyelin in response to TDP‐43 pathology in the disease‐affected motor cortex of amyotrophic lateral sclerosis (ALS) brain. Abstract Amyotrophic lateral sclerosis (ALS) is a rapidly progressing neurodegenerative disease characterized by the degeneration of motor neurons and the presence of TAR DNA‐binding protein 43 (TDP‐43 ...
Finula I. Isik, Russell Pickford, Nicolas Dzamko, Kerry‐Anne Rye, Woojin Scott Kim   +4 more
wiley   +1 more source

Storage time affects the level and diagnostic efficacy of plasma biomarkers for neurodegenerative diseases

Neural Regeneration Research
Several promising plasma biomarker proteins, such as amyloid-β (Aβ), tau, neurofilament light chain, and glial fibrillary acidic protein, are widely used for the diagnosis of neurodegenerative diseases.
Lifang Zhao, Mingkai Zhang, Qimeng Li, Xuemin Wang, Jie Lu, Ying Han, Yanning Cai   +6 more
doaj   +1 more source

Plasma Neurofilament Light and Glial Fibrillary Acidic Protein Levels over Thirty Days in a Porcine Model of Traumatic Brain Injury

, 2022
Samuel S. Shin, Marco M. Hefti, Vanessa Mazandi, David Issadore, David F. Meaney, Andrea Schneider, Ramon Diaz‐Arrastia, Todd J. Kilbaugh   +7 more
openalex   +2 more sources

Tau‐targeting active immunotherapy slows progression and reduces pathology in mouse models of tauopathy

Brain Pathology, EarlyView.
The efficacy of the novel anti‐tau active immunotherapy, p5555kb, was tested using two mouse models of tau pathology. p5555kb inoculation increased the survival rate and reduced tau pathology in tau‐overexpressing P301L mice and decreased tau seeding in the brains of C57BL/6 mice injected with human‐purified Alzheimer's disease tau.
Christopher M. Brown, Jeanne K. Brooks, Louise Kelly, Madeline M. Vroom, Matthew Longo, Jean‐Cosme Dodart, Roxana Carare, Justin D. Boyd   +7 more
wiley   +1 more source

Evaluation of cerebrospinal fluid ubiquitin C-terminal hydrolase-L1, glial fibrillary acidic protein, and neurofilament light protein as novel markers for the diagnosis of neurosyphilis among HIV-negative patients

, 2022
Rui Chen, Li‐Rong Lin, Yao Xiao, Wujian Ke, Tian‐Ci Yang   +4 more
openalex   +1 more source

Serum Neurofilament Light Chain and Glial Fibrillary Acidic Protein as Potential Diagnostic Biomarkers in Autism Spectrum Disorders: A Preliminary Study [PDF]

, 2023
Marta Simone, Andrea De Giacomo, Roberto Palumbi, Claudia Palazzo, Giuseppe Lucisano, Francesco Pompamea, Stefania Micella, Mara Pascali, Alessandra Gabellone, Lucia Marzulli, Paola Giordano, Concetta Domenica Gargano, Lucia Margari, Antonio Frigeri, Maddalena Ruggieri   +14 more
openalex   +1 more source

Dysphagia in Multiple System Atrophy Does Not Correlate with Serum Neurofilament Light Chain and Glial Fibrillary Acidic Protein

Movement Disorders, EarlyView.
Martin Klietz, Katharina Pannewitz‐Makaj, Franziska Baacke, Florian Wegner, Matthias Höllerhage, Lea Krey, Lan Ye, Christoph Schrader, Günter U. Höglinger, Tobias Warnecke   +9 more
wiley   +1 more source

LPC18:0 Secreted by Exogenous Neural Stem Cells Potentiates Neurogenesis and Functional Recovery via GPR55‐Mediated Signalling in Spinal Cord Injury

Cell Proliferation, EarlyView.
LPC18:0 secreted by exogenous neural stem cells potentiates neurogenesis via the GPR55/AKT/GSK3β signalling axis, which ultimately promotes spinal cord injury recovery. ABSTRACT Spinal cord injury (SCI) is a devastating condition with limited therapeutic options. Although neural stem cell (NSC) transplantation shows regenerative potential, its efficacy
Dong Chen, Shuo Liu, Le‐Yi Tu, Ming‐Mei Yang, Cong‐Wang Xu, Yue Jiang, Hui Yang, Chen‐Xu Tai, Yan‐Ning Wang, Yuan‐Yuan Xie, Ping‐Ping Shen, Bin Wang   +11 more
wiley   +1 more source

Long‐term effects of a multidomain intervention on cognitive function and metabolic control in older adults with type 2 diabetes and mild cognitive impairment: A 42‐month follow‐up of the J‐MIND‐Diabetes study

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims This study investigated the long‐term effects of a multidomain intervention on cognition and metabolic control in patients with type 2 diabetes and mild cognitive impairment (MCI). Materials and methods Outpatients aged 70–85 years were randomized to an 18‐month multidomain intervention (comprising metabolic/vascular risk management ...
Taiki Sugimoto, Takuya Omura, Atsushi Araki, Chie Haneda, Keiko Honda, Minoru Kishi, Toshimasa Takahashi, Kenji Toyoshima, Suguru Tsuume, Kazuaki Uchida, Hisashi Noma, Ayaka Onoyama, Yoko Yokoyama, Mio Shinozaki, Paul K. Crane, Takashi Sakurai, J‐MIND‐Diabetes Study Group   +16 more
wiley   +1 more source

Phosphorylation-Induced Mechanical Regulation of Intrinsically Disordered Neurofilament Proteins. [PDF]

Biophys J, 2017
Malka-Gibor E, Kornreich M, Laser-Azogui A, Doron O, Zingerman-Koladko I, Harapin J, Medalia O, Beck R.   +7 more
europepmc   +1 more source