Results 221 to 230 of about 50,787 (316)

Top-Down Proteomics Study of Aging and Sexual Dimorphism of Zebrafish Brains. [PDF]

J Mass Spectrom
Askarani MF, Poulos W, Dashtaki MR, Sadeghi SA, Cibelli JB, Fang F, Sun L.   +6 more
europepmc   +1 more source

Targeted blood proteome profiling using NULISAseq identifies a high‐performance biomarker panel for Aβ pathology quantification and staging

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION While current blood‐based biomarkers for Alzheimer's disease (AD) are effective for determining amyloid beta (Aβ) pathology positivity/negativity, they are insufficient for quantifying Aβ plaque deposition. METHODS We profiled 325 plasma proteins in a Hong Kong Chinese cohort using the Nucleic Acid Linked Immuno‑Sandwich Assay ...
Wenyue Zheng, Yuanbing Jiang, Hiu Yi Wong, Wan Wa Wong, Lily K. W. Cheng, Elaine Y. L. Cheng, Bonnie W. Y. Wong, Ronnie M. N. Lo, Siu Ki Leung, Fanny C. Ip, Jacqueline K. Y. Yuen, Yat Fung Shea, Wai Ming Wong, Chun Keung Shum, Hok Man Wai, Vincent C. T. Mok, Timothy C. Y. Kwok, Kin Y. Mok, Amanda Heslegrave, John Hardy, Henrik Zetterberg, Amy K. Y. Fu, Nancy Y. Ip   +22 more
wiley   +1 more source

Fractionated Gamma Knife Radiation for Papillary Tumor of the Pineal Region: A Case Report and Literature Review

Clinical Case Reports, Volume 14, Issue 2, February 2026.
ABSTRACT Papillary tumor of the pineal region (PTPR) is a rare central nervous system neoplasm with an unpredictable clinical course. Gross total resection, the preferred treatment, is often unachievable due to the tumor's deep‐seated location, necessitating alternative therapies.
Arad Iranmehr, Negin Safari Dehnavi, Mohammad Shirani, Reza Samiee, Moein Targhi, Nooshin Banaee, Fatemeh Jafari   +6 more
wiley   +1 more source

Distribution of Voltage‐Gated Sodium Channels and Scaffolding Proteins on Vestibular Calyx Ending Delineates the Axon Initial Segment

Journal of Comparative Neurology, Volume 534, Issue 2, February 2026.
Various sodium channel isoforms and their scaffolding proteins are found in four different microdomains in vestibular calyx‐bearing afferents. These microdomains serve different purposes, analogous to the heminode, axon initial segment, and synaptic domains of other types of sensory afferents.
Anna Lysakowski, Aravind Chenrayan Govindaraju, Steven D. Price, Sophie Gaboyard‐Niay, Irina Calin‐Jageman, Robstein L. Chidavaenzi, Ruth Anne Eatock, Robert M. Raphael, Jay M. Goldberg   +8 more
wiley   +1 more source

Microbial‐Immune Interplay in CNS Autoimmune Diseases: Lessons from Animal Models and Clinical Studies

European Journal of Immunology, Volume 56, Issue 2, February 2026.
Mechanism of action of the intestinal microbiota on CNS autoimmune diseases. Environmental factors shape gut microbiota composition; dysbiosis alters microbial metabolites and antigenic signals. These modulate innate and adaptive immunity, affect barrier integrity, and influence CNS‐resident cells such as microglia and astrocytes, contributing to ...
Matteo Ceccon, Francesca Ronchi
wiley   +1 more source

Ras Homolog Enriched in Brain Protein Reverses Amyloid Beta-Induced Escape of Inflammatory Cytokine mRNAs From Immunoisolated RNA Processing Bodies of Glioblastoma Cells. [PDF]

FASEB J
Ray S, Mukherjee K, Bhattacharyya SN.
europepmc   +1 more source

Acute Intermittent Hypoxia Exerts Beneficial Effects and Promotes Repair in Male Mice in the Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis

Glia, Volume 74, Issue 2, February 2026.
Acute intermittent hypoxia is a novel, noninvasive therapy that shows promising and similar beneficial repair and remyelination following demyelination in male experimental autoimmune encephalomyelitis, as was previously shown in female mice. ABSTRACT Multiple sclerosis (MS) affects women more frequently than men, but the disease progresses more ...
Nataliya Tokarska, Josh Roberts, Sameer Rathnayaka Koralage, Justin M. A. Naniong, Jayne M. Johnston, Zelan Wei, Valerie M. K. Verge   +6 more
wiley   +1 more source

A Human Model of Oligodendrocyte Development Shows MCL‐1 Influences Oligodendrocyte Morphogenesis

Glia, Volume 74, Issue 2, February 2026.
A unified model of oligodendrocyte differentiation from human embryonic stem cells revealed that MCL‐1 is critical for regulating the expression of oligodendrocyte‐related genes and the morphogenesis of myelinating oligodendrocytes. ABSTRACT Oligodendrocytes are the myelinating cells of the central nervous system.
Melanie Gil, Marina R. Hanna, Vivian Gama   +2 more
wiley   +1 more source

Neuro‐Immune Crosstalk: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Neurons, immune cells, and other cellular components within the disease microenvironment (such as stromal cells and tumor cells) constitute a dynamically evolving ecosystem. Neurons directly modulate immune cell activity and inflammatory responses through the release of neurotransmitters (e.g., norepinephrine and CGRP), while also promoting tumor ...
Xin Guo, Hui Liu, Yu‐Jing Song, Jian‐Hua Wang, Danfeng Liu, Zhi‐Wei Zheng, Jia‐Jun Li, Boya Li, An Song, Wei He, Lei‐Lei Yang, Shuo Wang   +11 more
wiley   +1 more source

Plasma concentrations of glial fibrillary acidic protein, neurofilament light, and tau in Alexander disease [PDF]

Nicholas J. Ashton, Guglielmo Di Molfetta, Kübra Tan, Kaj Blennow, Henrik Zetterberg, Albee Messing   +5 more
openalex   +1 more source