Differential dynamics of neurofilament-H protein and neurofilament-L protein in neurons. [PDF]
The Journal of cell biology, 1994 Neurofilaments (NFs) are composed of triplet proteins, NF-H, NF-M, and NF-L. To understand the dynamics of NFs in vivo, we studied the dynamics of NF-H and compared them to those of NF-L, using the combination of microinjection technique and fluorescence recovery after photobleaching.
S, Takeda +3 more
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Minimal genetically encoded tags for fluorescent protein labeling in living neurons
Nature Communications, 2022 Site-specific labelling of proteins can be performed with unnatural amino acids combined with bioorthogonal click chemistry. Here the authors establish this in living neurons, using neurofilament light chain; they show combination with CRISPR/Cas9 ...
Aleksandra Arsić +4 more
doaj +1 more source
Characterization of immune response to neurofilament light in experimental autoimmune encephalomyelitis [PDF]
, 2013 PMCID: PMC3856490This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided ...
Amor, S +13 more
core +5 more sources
Diffuse axonal injury in brain trauma: insights from alterations in neurofilaments
Frontiers in Cellular Neuroscience, 2014 Traumatic brain injury from penetrating or closed forces to the cranium can result in a range of forms of neural damage, which culminate in mortality or impart mild to significant neurological disability.
Declan Guenter Siedler +9 more
doaj +1 more source
Serum neurofilament light reflects cognitive dysfunctions in children with obstructive sleep apnea
BMC Pediatrics, 2022 Background In children, obstructive sleep apnea (OSA) can cause cognitive dysfunctions. Amyloid-beta and tau are elevated in OSA. Neurofilament light (NfL) is a marker of neuro-axonal damage, but there are no reports of NfL for OSA.
Yewen Shi +12 more
doaj +1 more source
Cas Adaptor Proteins Coordinate Sensory Axon Fasciculation. [PDF]
, 2018 Development of complex neural circuits like the peripheral somatosensory system requires intricate mechanisms to ensure axons make proper connections. While much is known about ligand-receptor pairs required for dorsal root ganglion (DRG) axon guidance ...
Estep, Jason A +5 more
core +2 more sources
TDP-43 mislocalization drives neurofilament changes in a novel model of TDP-43 proteinopathy
Disease Models & Mechanisms, 2021 Mislocalization of the TAR DNA-binding protein 43 (TDP-43; encoded by TARDBP) from the nucleus to the cytoplasm is a common feature of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD ...
Rachel Atkinson +5 more
doaj +1 more source
14-3-3 proteins interact with neurofilament protein-L and regulate dynamic assembly of neurofilaments [PDF]
Journal of Cell Science, 2013 Summary Neurofilament protein-L (NF-L) is the core component of neurofilaments. Recent studies indicate that the NF-L mutations reported in human Charcot–Marie–Tooth (CMT) disease lead to the formation of NF-L aggregates and result in axon degeneration of motor and sensory neurons, which are thought to be the cause of CMT disease type 2E.
Linqing, Miao +4 more
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Analysis of the Catecholaminergic Phenotype in Human SH-SY5Y and BE(2)-M17 Neuroblastoma Cell Lines upon Differentiation [PDF]
, 2015 Human cell lines are often used to investigate cellular pathways relevant for physiological or pathological processes or to evaluate cell toxicity or protection induced by different compounds, including potential drugs.
Beltramini, Mariano +7 more
core +8 more sources
Frontiers in Neurology, 2018 Aims and hypothesisHypoxic-ischemic encephalopathy (HIE) remains an important cause of death and disability in newborns. Mild therapeutic hypothermia (TH) is safe and effective; however, there are no tissue biomarkers available at the bedside to select ...
Divyen K. Shah +10 more
doaj +1 more source