Results 291 to 300 of about 50,787 (316)

Neurofilament triplet proteins

1999
Abstract The neurofilament triplet proteins (i.e. the low, middle, and high molecular weight neurofilament proteins NF-L, NF-M, and NF-H) are the most abundant cytoskeletal components found in neurones and their precursor cells. In vivo they assemble into obligate heteropolymeric filaments that, different from the other intermediate ...
Harald Herrmann, Ueli Aebi
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Neurofilament 68 and Neurofilament 200 Protein Levels Decrease After Traumatic Brain Injury

Journal of Neurotrauma, 1994
We have examined the effect of lateral cortical impact injury on the levels of axonal cytoskeletal proteins in adult rats. Traumatic brain injury (TBI) causes a significant decrease in the protein levels of two prominent neurofilament (NF) proteins, NF68 and NF200.
R, Posmantur, R L, Hayes, C E, Dixon, W C, Taft   +3 more
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Genetic Manipulation of Neurofilament Protein Phosphorylation

2016
Neurofilament biology is important to understanding structural properties of axons, such as establishment of axonal diameter by radial growth. In order to study the function of neurofilaments, a series of genetically modified mice have been generated. Here, we describe a brief history of genetic modifications used to study neurofilaments, as well as an
Maria R, Jones, Eric, Villalón, Michael L, Garcia   +2 more
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A batchwise purification procedure of neurofilament proteins

Analytical Biochemistry, 1983
A rapid batchwise purification procedure for neurofilament proteins from bovine spinal cord is described. A crude filament fraction can be obtained by treating the tissue with Triton X-100, followed by centrifugation through sucrose. From this crude filament fraction the protein is processed through a batch purification procedure using hydroxyapatite ...
S, Tokutake, S B, Hutchison, J S, Pachter, R K, Liem   +3 more
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The protein subunit of calf brain neurofilament

Journal of Neurobiology, 1974
AbstractA preparation of the protein subunits from calf neurofilaments has been obtained. Axon segments from an homogenate of calf brain white matter have been concentrated by a subcellular fractionation procedure. After further steps to achieve a complete elimination of unbound lipid, the neurofilament protein was dissolved in 4M guanidine ...
P F, Davison, B, Winslow
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Evolutionary trends of neurofilament proteins in fish

Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 1991
1. Neurofilament complement was studied in an early chordate (Ciona intestinalis) and six fish species by immunoblot with antisera specific for each of the three mammalian NF subunits. 2. The anti-NF-H and anti-NF-M antisera were characterized as strictly specific for phosphorylated epitopes located in the carboxyterminal domain. 3. The NF-L subunit is
MENCARELLI C., MAGI B., MARZOCCHI B., CONTORNI M., PALLINI V.   +4 more
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Chromatin Proteins Share Antigenic Determinants with Neurofilaments

Journal of Neurochemistry, 1985
Abstract:Antigenic determinants common to distinct proteins may be unambiguously identified by the use of monoclonal antibodies. Some monoclonal antibodies to mammalian neurofilaments have recently been shown to cross‐react with the neurofibrillary tangles found at high density in the brains of senile dements with Alzheimers disease (SDAT).
J N, Wood, N B, Lathangue, D R, McLachlan, B J, Smith, B H, Anderton, A J, Dowding   +5 more
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Neurofilament proteins in avian auditory hair cells

The Journal of Comparative Neurology, 1997
The distribution of middle-weight neurofilament protein (NF-M), an intermediate filament of neurons, was examined in the developing and mature avian inner ear by using immunocytochemical techniques. NF-M was detected in auditory hair cells and VIIIth cranial nerve neurons.
E C, Oesterle, D I, Lurie, E W, Rubel
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Degradation of neurofilament protein in cerebral ischemia

Journal of Neurosurgery, 1989
✓ Degradation of neurofilament (NF) triplet proteins: NF200 (molecular weight (MW) 200,000), NF150 (MW 150,000), and NF68 (MW 68,000) as well as of other cytoskeletal proteins in the rat brain during ischemia was investigated. Sodium dodecyl sulfate-gel electrophoresis and immunoblot methods with anti-NF200 antibody were used for the study.
N, Ogata, Y, Yonekawa, W, Taki, R, Kannagi, T, Murachi, T, Hamakubo, H, Kikuchi   +6 more
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Neurofilament Proteins as Prognostic Biomarkers in Neurological Disorders

Current Pharmaceutical Design, 2020
Neurofilaments: light, medium, and heavy (abbreviated as NF-L, NF-M, and NF-H, respectively), which belong to Type IV intermediate filament family (IF), are neuron-specific cytoskeletal components. Neurofilaments are axonal structural components and integral components of synapses, which are important for neuronal electric signal transmissions along ...
Yichen Lee, Bo H. Lee, William Yip, Pingchen Chou, Bak-Sau Yip   +4 more
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