Results 41 to 50 of about 50,787 (316)

Maintenance and degradation of proteins in intact and severed axons: Implications for the mechanism of long-term survival of anucleate crayfish axons [PDF]

, 1995
Protein maintenance and degradation are examined in the severed distal (anucleate) portions of crayfish medial giant axons (MGAs), which remain viable for over 7 months following axotomy.
Bittner, George D., Storm, Elaine E., Tanner, Sandra L.   +2 more
core   +1 more source

Pea3 transcription factor promotes neurite outgrowth

Frontiers in Molecular Neuroscience, 2014
Pea3 subfamily of ETS transcription factors consist of three major proteins, Pea3, ERM and ER81. Although important for many different tissues that exhibit branching morphogenesis, the function of Pea3 family in nervous system development and ...
BASAK eKANDEMIR, BERRAK eCAGLAYAN, BARBARA eHAUSOTT, BURCU eERDOGAN, UGUR eDAG, OZLEM eDEMIR, MELIS eSAVASAN SOGUT, Lars eKlimaschewski, ISIL eAKSAN KURNAZ   +8 more
doaj   +1 more source

Induction of autophagy mitigates TDP-43 pathology and translational repression of neurofilament mRNAs in mouse models of ALS/FTD

Molecular Neurodegeneration, 2021
Background TDP-43 proteinopathy is a pathological hallmark of many neurodegenerative diseases including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). So far, there is no therapy available for these neurodegenerative diseases.
Sunny Kumar, Daniel Phaneuf, Pierre Cordeau, Hejer Boutej, Jasna Kriz, Jean-Pierre Julien   +5 more
doaj   +1 more source

Quantification of mutant huntingtin protein in cerebrospinal fluid from Huntington's disease patients. [PDF]

, 2015
Quantification of disease-associated proteins in the cerebrospinal fluid (CSF) has been critical for the study and treatment of several neurodegenerative disorders; however, mutant huntingtin protein (mHTT), the cause of Huntington's disease (HD), is at ...
Andreas Weiss, Benjamini, Blair R. Leavitt, Douglas Langbehn, Douglas Macdonald, Edward J. Wild, Henrik Zetterberg, James R.C. Miller, Jeromin, Ko, Lewczuk, Nicola Robertson, Rainer Kuhn, Roberto Boggio, Rosengren, Salman Haider, Sarah J. Tabrizi   +16 more
core   +1 more source

A Single Dose of Atorvastatin Applied Acutely after Spinal Cord Injury Suppresses Inflammation, Apoptosis, and Promotes Axon Outgrowth, Which Might Be Essential for Favorable Functional Outcome. [PDF]

, 2018
The aim of our study was to limit the inflammatory response after a spinal cord injury (SCI) using Atorvastatin (ATR), a potent inhibitor of cholesterol biosynthesis.
Bacova, Maria, Bimbova, Katarina, Fedorova, Jana, Galik, Jan, Jachova, Jana, Kisucka, Alexandra, Lukacova, Nadezda, Marsala, Martin, Papcunova, Stefania, Pavel, Jaroslav, Stropkovska, Andrea, Zavacky, Peter   +11 more
core   +2 more sources

Impaired Neurofilament Integrity and Neuronal Morphology in Different Models of Focal Cerebral Ischemia and Human Stroke Tissue

Frontiers in Cellular Neuroscience, 2018
As part of the neuronal cytoskeleton, neurofilaments are involved in maintaining cellular integrity. In the setting of ischemic stroke, the affection of the neurofilament network is considered to mediate the transition towards long-lasting tissue damage.
Bianca Mages, Bianca Mages, Bianca Mages, Susanne Aleithe, Susanne Aleithe, Stephan Altmann, Stephan Altmann, Alexandra Blietz, Alexandra Blietz, Björn Nitzsche, Björn Nitzsche, Henryk Barthel, Anja K. E. Horn, Constance Hobusch, Wolfgang Härtig, Martin Krueger, Dominik Michalski   +16 more
doaj   +1 more source

Phosphorylated proteomics-based analysis of the effects of semaglutide on hippocampi of high-fat diet-induced-obese mice

Diabetology & Metabolic Syndrome, 2023
The aim of this paper was to investigate the effects of semaglutide on phosphorylated protein expression, and its neuroprotective mechanism in hippocampi of high-fat-diet-induced obese mice. In total, 16 obese mice were randomly divided into model group (
Xiaoyi Chen, Liang Ma, Kexin Gan, Xiaoyu Pan, Shuchun Chen   +4 more
doaj   +1 more source

Neurofilament light chain in the assessment of patients with multiple sclerosis

Arquivos de Neuro-Psiquiatria
Multiple sclerosis (MS) is an autoimmune, inflammatory, and degenerative disease of the central nervous system. Axonal degeneration is triggered by inflammation and is the pathological substrate of progressive disability in patients with MS.
Renan Barros DOMINGUES, Gustavo Bruniera Peres FERNANDES, Fernando Brunale Vilela de Moura LEITE, Carlos SENNE   +3 more
doaj   +1 more source

Fingolimod modulates microglial activation to augment markers of remyelination [PDF]

, 2011
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work ...
Baker, D, Giovannoni, G, Jackson, SJ
core   +3 more sources

Anti-neurofilament heavy chain antibody-associated encephalitis: one case report and literature review

Chinese Journal of Contemporary Neurology and Neurosurgery
Objective To report and analyze the clinical features of the first documented case in China of anti-neurofilament heavy chain (NfH) antibody-associated encephalitis.
CHENG Jing, ZHANG Wei-wei, ZHOU Qin-ming, MENG Huan-yu, HE Lu, CHEN Sheng   +5 more
doaj   +1 more source