Neurogenic Orthostatic Hypotension in Parkinson Disease: A Primer [PDF]
Neurology and Therapy, 2019 Abstract Parkinson disease (PD) is associated with a variety of motor and non-motor clinical manifestations, including cardiovascular autonomic dysfunction. Neurogenic orthostatic hypotension (nOH) is a potentially serious manifestation of cardiovascular
Jeremy K. Cutsforth-Gregory +1 more
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Droxidopa as an effective treatment for refractory neurogenic orthostatic hypotension and reflex bradycardia in amyloid light-chain amyloidosis: a case report [PDF]
Journal of Medical Case Reports, 2020 Background Droxidopa is an oral treatment for the stepwise treatment of neurogenic orthostatic hypotension from autonomic dysfunction. It has been shown to be useful predominantly with neurogenic orthostatic hypotension secondary to Parkinson’s disease ...
Annie H. Ho +4 more
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Neurogenic Orthostatic Hypotension: a Common Complication of Successful Pancreas Transplantation [PDF]
Transplantation Direct, 2021 Background. Orthostatic hypotension (OH) is a poorly understood complication of simultaneous pancreas–kidney (SPK) transplantation. We sought to determine the incidence, timing, and relationship of OH to rapid glycemic control in the early posttransplant
Samantha A. Kuten, PharmD +9 more
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Genetics of Neurogenic Orthostatic Hypotension in Parkinson’s Disease, Results from a Cross-Sectional In Silico Study [PDF]
Brain Sciences, 2023 The genetic basis of Neurogenic Orthostatic Hypotension (NOH) in Parkinson’s disease (PD) has been inadequately explored. In a cross-sectional study, we examined the association between NOH and PD-related single-nucleotide polymorphisms (SNPs) and mapped
Guenson Chevalier +7 more
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Neurogenic orthostatic hypotension after treatment with sorafenib. [PDF]
BMJ Case Rep, 2022 A man in his 70s with a history of fatigue, abdominal pain, and a palpable abdominal mass was found to have a peritoneal desmoid tumour. One year after diagnosis, he was prescribed sorafenib to limit tumour growth. Two months later, he developed dyspnoea on exertion and lower extremity weakness and was reported to have supine hypertension and ...
Wegner Wippel C +3 more
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Neurogenic Orthostatic Hypotension. Lessons From Synucleinopathies. [PDF]
Am J Hypertens, 2021 Abstract Maintenance of upright blood pressure critically depends on the autonomic nervous system and its failure leads to neurogenic orthostatic hypotension (NOH). The most severe cases are seen in neurodegenerative disorders caused by abnormal α-synuclein deposits: multiple system atrophy (MSA), Parkinson’s disease, Lewy body dementia,
Idiaquez JF +3 more
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Neurogenic Orthostatic Hypotension: State of the Art and Therapeutic Strategies [PDF]
Clinical Medicine Insights: Cardiology, 2020 Neurogenic orthostatic hypotension (nOH) is a subtype of orthostatic hypotension in which patients have impaired regulation of standing blood pressure due to autonomic dysfunction. Several primary and secondary causes of this disease exist.
Dinesh K Kalra, Anvi Raina, Sumit Sohal
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Reduction in Pulse Pressure during Standing Can Distinguish Neurogenic Orthostatic Hypotension [PDF]
Diagnostics, 2021 Background: We investigated whether changes in the pulse pressure (PP) reduction ratio during the head-up tilt test (HUTT) can aid in distinguishing neurogenic orthostatic hypotension (OH) from non-neurogenic OH. Methods: We enrolled consecutive patients
Kyu-On Jung +3 more
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Efficacy of atomoxetine versus midodrine for neurogenic orthostatic hypotension [PDF]
Annals of Clinical and Translational Neurology, 2020 Objective The efficacy and safety of 1‐month atomoxetine and midodrine therapies were compared. Three‐month atomoxetine and combination therapies were investigated for additional benefits.
Jung‐Ick Byun +13 more
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Droxidopa Persistence in Neurogenic Orthostatic Hypotension May Be Affected by Titration Approach [PDF]
International Journal of General Medicine, 2021 Fahd Amjad,1 Brett Polenchar,2 Antonella Favit3 1Department of Neurology, Georgetown University Hospital Pasquerilla Healthcare Center, Washington, DC, USA; 2Business Insights, Lundbeck, Deerfield, IL, USA; 3Medical Affairs, Lundbeck, Deerfield, IL ...
Amjad F, Polenchar B, Favit A
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