Retrospective Analysis of Phase 4 Clinical Trial to Evaluate the Sustained Effect of Droxidopa in Symptomatic Neurogenic Orthostatic Hypotension [PDF]
, 2021 One of the biggest challenges patients with rare diseases face is the availability of safe and effective treatment options. Patients with symptomatic neurogenic orthostatic hypotension have a very limited number of pharmacological treatment options ...
Lombard, Diandra
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Six-Month Use of Droxidopa for Neurogenic Orthostatic Hypotension [PDF]
Movement Disorders Clinical Practice, 2019 Italo Biaggioni +2 more
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Progressively invalidating orthostatic hypotension: A common symptom for a challenging diagnosis
Journal of Research in Medical Sciences, 2016 We discuss here an uncommon condition of neurogenic hypotension in the context of immunoglobulin light chain (amyloid light-chain) amyloidosis. The most serious feature was autonomic nervous system impairment, mainly characterized by severe refractory ...
Serena Pelusi +6 more
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Norepinephrine Precursor Therapy in Neurogenic Orthostatic Hypotension [PDF]
Circulation, 2003 Background— In patients with neurogenic orthostatic hypotension (NOH), the availability of the sympathetic neurotransmitter norepinephrine (NE) in the synaptic cleft is insufficient to maintain blood pressure while in the standing posture.
Horacio, Kaufmann +7 more
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Pyridostigmine Treatment Trial in Neurogenic Orthostatic Hypotension [PDF]
Archives of Neurology, 2006 Midodrine hydrochloride is the only drug demonstrated in a placebo-controlled treatment trial to improve orthostatic hypotension (OH) but it significantly worsens supine hypertension. By enhancing ganglionic transmission, pyridostigmine bromide can potentially ameliorate OH without worsening supine hypertension.To evaluate the efficacy of a single 60 ...
Wolfgang, Singer +8 more
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Droxidopa and reduced falls in a trial of Parkinson disease patients with Neurogenic orthostatic hypotension [PDF]
, 2016 Objectives: Droxidopa is a prodrug of norepinephrine indicated for the treatment of orthostatic dizziness, lightheadedness, or the "feeling that you are about to black out" in adult patients with symptomatic neurogenic orthostatic hypotension caused by ...
Robert A. Hauser +9 more
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Reduced brainstem functional connectivity in patients with peripheral autonomic failure
NeuroImage: Clinical, 2019 Autonomic homeostasis is dependent upon several brainstem nuclei, as well as several cortical and subcortical structures. Together, these sites make up, in part, the central autonomic network.
Jacquie Baker, Kurt Kimpinski
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Cerebral perfusion in neurogenic orthostatic hypotension [PDF]
The Lancet Neurology, 2008 Contains fulltext : 69875.pdf (Author’s version postprint ) (Open Access)
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An Unusual Case of Neurogenic Orthostatic Hypotension Without Parkinsonian Features
Annals of Internal Medicine: Clinical CasesOrthostatic hypotension is a common cause of syncope, especially in the older adult population. While it is a commonly encountered issue as a cause of syncope, neurogenic orthostatic hypotension (nOH) is less common.
Betul Gok Yavuz, Darian Fard, Asma Malik
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Frontiers in Surgery, 2022 BackgroundIntracranial hypotension (IH) is usually associated with cerebrospinal fluid (CSF) leakage and/or CSF hypotension, and epidural blood patch (EBP) therapy has been proven to be effective for treating spontaneous IH and post-dural puncture ...
Hua Huang +4 more
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