Partial pharmacologic blockade shows sympathetic connection between blood pressure and cerebral blood flow velocity fluctuations [PDF]
Cerebral autoregulation (CA) dampens transfer of blood pressure (BP)-fluctuations onto cerebral blood flow velocity (CBFV). Thus, CBFV-oscillations precede BP-oscillations.
Hauck, P +10 more
core +1 more source
Integrated analysis of droxidopa trials for neurogenic orthostatic hypotension
Background Droxidopa, a prodrug of norepinephrine, was approved for treatment of neurogenic orthostatic hypotension (nOH) due to primary autonomic disorders based on 3 randomized double-blind studies.
Italo Biaggioni +3 more
doaj +1 more source
BackgroundIntracranial hypotension (IH) is usually associated with cerebrospinal fluid (CSF) leakage and/or CSF hypotension, and epidural blood patch (EBP) therapy has been proven to be effective for treating spontaneous IH and post-dural puncture ...
Hua Huang +4 more
doaj +1 more source
Reduced brainstem functional connectivity in patients with peripheral autonomic failure
Autonomic homeostasis is dependent upon several brainstem nuclei, as well as several cortical and subcortical structures. Together, these sites make up, in part, the central autonomic network.
Jacquie Baker, Kurt Kimpinski
doaj +1 more source
Cerebral perfusion in neurogenic orthostatic hypotension [PDF]
Contains fulltext : 69875.pdf (Author’s version postprint ) (Open Access)
openaire +2 more sources
Prospects for Droxidopa in Neurogenic Orthostatic Hypotension [PDF]
See related article, pp 101–107 Neurogenic orthostatic hypotension (nOH) is a debilitating disorder defined by a sustained decrease in systolic blood pressure of 20 mm Hg or in diastolic blood pressure of 10 mm Hg within 3 minutes of head-up tilt or standing.1 The disorder is associated with attenuated increases in plasma norepinephrine and peripheral
Amanda J, Ross, Julian M, Stewart
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Cardiac 123I-MIBG Scintigraphy in Neurodegenerative Parkinson Syndromes: Performance and Pitfalls in Clinical Practice [PDF]
Purpose: Cardiac [I-123]metaiodobenzylguanidine scintigraphy (123I-MIBG), reflecting postganglionic cardiac autonomic denervation, is proposed for early detection of Parkinson's disease (PD; reduced tracer uptake) and separation from Multiple System ...
Lipp, Axel +2 more
core +3 more sources
Orthostatic hypotension (OH) frequently accompanies autonomic dysfunction and is an important risk factor for cognitive impairment in Parkinson's disease (PD).
Ryota Tanaka +7 more
doaj +1 more source
Pyridostigmine Treatment Trial in Neurogenic Orthostatic Hypotension [PDF]
Midodrine hydrochloride is the only drug demonstrated in a placebo-controlled treatment trial to improve orthostatic hypotension (OH) but it significantly worsens supine hypertension. By enhancing ganglionic transmission, pyridostigmine bromide can potentially ameliorate OH without worsening supine hypertension.To evaluate the efficacy of a single 60 ...
Wolfgang, Singer +8 more
openaire +2 more sources
Reliability of orthostatic beat-to-beat blood pressure tests: implications for population and clinical studies [PDF]
Objective: To assess the test–retest reliability of orthostatic beat-to-beat blood pressure responses to active standing and related clinical definitions of orthostatic hypotension. Methods: A random sample of community-dwelling older adults from the pan-
A Costa +34 more
core +1 more source

