Neurogenic Orthostatic Hypotension. Lessons From Synucleinopathies [PDF]
American Journal of Hypertension, 2020 Abstract Maintenance of upright blood pressure critically depends on the autonomic nervous system and its failure leads to neurogenic orthostatic hypotension (NOH). The most severe cases are seen in neurodegenerative disorders caused by abnormal α-synuclein deposits: multiple system atrophy (MSA), Parkinson’s disease, Lewy body dementia,
Juan Francisco Idiaquez +3 more
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Norepinephrine reuptake blockade to treat neurogenic orthostatic hypotension [PDF]
Clinical Autonomic Research, 2021 <jats:title>Abstract</jats:title><jats:p>GNSS satellite and receiving antennas exhibit group delay variations (GDV), which affect code pseudorange measurements. Like antenna phase center variations, which affect phase measurements, they are frequency-dependent and vary with the direction of the transmitted and received signal.
Eisenhofer, Graeme, Goldstein, David S.
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Neurogenic Orthostatic Hypotension: State of the Art and Therapeutic Strategies [PDF]
Clinical Medicine Insights: Cardiology, 2020 Neurogenic orthostatic hypotension (nOH) is a subtype of orthostatic hypotension in which patients have impaired regulation of standing blood pressure due to autonomic dysfunction. Several primary and secondary causes of this disease exist.
Dinesh K Kalra, Anvi Raina, Sumit Sohal
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Genetics of Neurogenic Orthostatic Hypotension in Parkinson’s Disease, Results from a Cross-Sectional In Silico Study [PDF]
Brain Sciences, 2023 The genetic basis of Neurogenic Orthostatic Hypotension (NOH) in Parkinson’s disease (PD) has been inadequately explored. In a cross-sectional study, we examined the association between NOH and PD-related single-nucleotide polymorphisms (SNPs) and mapped
Guenson Chevalier +7 more
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Reduction in Pulse Pressure during Standing Can Distinguish Neurogenic Orthostatic Hypotension [PDF]
Diagnostics, 2021 Background: We investigated whether changes in the pulse pressure (PP) reduction ratio during the head-up tilt test (HUTT) can aid in distinguishing neurogenic orthostatic hypotension (OH) from non-neurogenic OH. Methods: We enrolled consecutive patients
Kyu-On Jung +3 more
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Efficacy of atomoxetine versus midodrine for neurogenic orthostatic hypotension [PDF]
Annals of Clinical and Translational Neurology, 2020 Objective The efficacy and safety of 1‐month atomoxetine and midodrine therapies were compared. Three‐month atomoxetine and combination therapies were investigated for additional benefits.
Jung‐Ick Byun +13 more
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Association of neurogenic orthostatic hypotension with cognitive decline in Parkinson’s disease: a longitudinal cohort study [PDF]
Frontiers in NeurologyIntroductionNeurogenic orthostatic hypotension (nOH), a common non-motor feature of Parkinson’s disease (PD), is defined as a sustained drop in blood pressure (BP) upon standing due to autonomic dysfunction.
Neda Bagheri +2 more
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Droxidopa Persistence in Neurogenic Orthostatic Hypotension May Be Affected by Titration Approach [PDF]
International Journal of General Medicine, 2021 Fahd Amjad,1 Brett Polenchar,2 Antonella Favit3 1Department of Neurology, Georgetown University Hospital Pasquerilla Healthcare Center, Washington, DC, USA; 2Business Insights, Lundbeck, Deerfield, IL, USA; 3Medical Affairs, Lundbeck, Deerfield, IL ...
Amjad F, Polenchar B, Favit A
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Characterization of the changes in supine blood pressure with long‐term use of droxidopa in patients with neurogenic orthostatic hypotension [PDF]
Health Science Reports, 2021 Background and Aims Patients with neurogenic orthostatic hypotension (nOH) due to autonomic dysfunction may also experience supine hypertension (defined as supine systolic blood pressure [SBP] ≥140 mmHg).
L. Arthur Hewitt +5 more
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Psychometric validation of a patient-reported single-item assessment of ‘Good Day Bad Day’ in a neurogenic orthostatic hypotension population treated with droxidopa [PDF]
Journal of Market Access & Health Policy, 2022 Background Symptoms of neurogenic orthostatic hypotension (nOH), including lightheadedness/dizziness, presyncope, syncope, and falls, can lead to impaired functional ability and reduced quality of life.
Clément François +5 more
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