Results 101 to 110 of about 17,069 (317)

Cerebrospinal fluid replacement solutions promote neuroglia migratory behaviors and spinal explant outgrowth in microfluidic culture

Journal of Tissue Engineering and Regenerative Medicine, 2020
Disorders of the nervous system (NS) impact millions of adults, worldwide, as a consequence of traumatic injury, genetic illness, or chronic health conditions. Contemporary studies have begun to incorporate neuroglia into emerging NS therapies to harness
Richard N. Cliver, B. Ayers, A. Brady, B. Firestein, Maribel Vazquez   +4 more
semanticscholar   +1 more source

“Therapies Through Gut:” Targeted Drug Delivery for Non‐Gastrointestinal Diseases by Oral Administration

Advanced Healthcare Materials, EarlyView.
Schematic illustration of the mechanism of targeted delivery of nanoparticles including 1) paracellular, 2) endolysosomal escape, 3) receptor mediated endocytosis, and 4) M cell mediated transport for non‐GI diseases by oral administration such as atherosclerosis, cancer, diabetes, and brain diseases. Abstract Oral drug delivery is a promising approach
Subarna Ray, Shehzahdi S. Moonshi, Hang Thu Ta   +2 more
wiley   +1 more source

An In Situ Curing, Shear‐Responsive Biomaterial Designed for Durable Embolization of Microvasculature

Advanced Healthcare Materials, EarlyView.
NeoCast is a next‐generation, solvent‐free, non‐adhesive liquid embolic designed for indications where deep occlusion is desired (e.g., tumors and chronic subdural hematoma). This novel agent offers ideal embolic properties: injectability, controllability, excellent visibility, and biocompatibility.
Quynh P. Pham, Jeffrey V. Groom II, Chander Sadasivan, David J. Fiorella, David C. Madoff, Lee‐Jae Guo, Michael Fornaciari, Courtney Guertin, Craig Wiltsey, Lee Core, Jonathan Merlo, William Wustenberg, Renu Virmani, Adam S. Arthur, Robert S. Langer, George M. Whitesides, Upma Sharma   +16 more
wiley   +1 more source

Berberine reduces neuroglia activation and inflammation in streptozotocin-induced diabetic mice

International Journal of Immunopathology and Pharmacology, 2019
We aimed to analyze the action of berberine on the neuropathic pain and neuroglia activation in experimental diabetes mellitus (DM) model. Diabetes in mice was induced by intraperitoneal injection of streptozotocin (STZ) followed by the administration of
Mei Liu, Linlin Gao, N. Zhang
semanticscholar   +1 more source

Engineering the Future of Restorative Clinical Peripheral Nerve Surgery

Advanced Healthcare Materials, EarlyView.
What if damaged nerves could regenerate more effectively? This review unveils cutting‐edge strategies to restore nerve function, from biomaterial scaffolds and bioactive molecules to living engineered tissues. By accelerating axonal regrowth, preserving Schwann cells, and enhancing connectivity, these approaches are reshaping nerve repair—offering new ...
Justin C. Burrell, Zarina S. Ali, Eric L. Zager, Joseph M. Rosen, Mykhailo M. Tatarchuk, D. Kacy Cullen   +5 more
wiley   +1 more source

3D Organotypic Spinal Cultures: Exploring Neuron and Neuroglia Responses Upon Prolonged Exposure to Graphene Oxide

Frontiers in Systems Neuroscience, 2019
Graphene-based nanomaterials are increasingly engineered as components of biosensors, interfaces or drug delivery platforms in neuro-repair strategies. In these developments, the mostly used derivative of graphene is graphene oxide (GO).
Mattia Musto, R. Rauti, A. F. Rodrigues, E. Bonechi, C. Ballerini, Kostas Kostarelos, L. Ballerini   +6 more
semanticscholar   +1 more source

Multifunctional Neural Probes Enable Bidirectional Electrical, Optical, and Chemical Recording and Stimulation In Vivo

Advanced Materials, EarlyView.
Convergence drawing is used to create flexible, microscale, multifunctional fiber‐based neural probes. Optimized materials selection enables individual devices to perform neural recording, electrical stimulation, optogenetics, fiber photometry, fluid delivery, and voltammetric neurotransmitter detection in rodents.
Nicolette Driscoll, Marc‐Joseph Antonini, Taylor M. Cannon, Pema Maretich, Greatness Olaitan, Valerie Doan Phi Van, Keisuke Nagao, Atharva Sahasrabudhe, Emmanuel Vargas Paniagua, Ethan J. Frey, Ye Ji Kim, Sydney Hunt, Melissa Hummel, Sanju Mupparaju, Alan Jasanoff, B. Jill Venton, Polina Anikeeva   +16 more
wiley   +1 more source

Recent Advances in Stimuli‐Responsive Materials and Soft Robotic Actuators for Bioelectronic Medicine

Advanced Materials, EarlyView.
This review explores the integration of responsive materials and soft robotic actuators with implantable electronics to address key challenges in bioelectronic medicine. By enabling shape actuation, these technologies improve deployment, adaptability, and accuracy in minimally invasive procedures.
Chaoqun Dong, George G. Malliaras
wiley   +1 more source

Mitochondrial Transplantation via Magnetically Responsive Artificial Cells Promotes Intracerebral Hemorrhage Recovery by Supporting Microglia Immunological Homeostasis

Advanced Materials, Volume 37, Issue 13, April 2, 2025.
A type of magnetically responsive artificial cells (ACs) has been developed, demonstrating the loading of mitochondria and self‐enclosure processes to ensure the protection of mitochondrial transport via the bloodstream. The treatment with ACs effectively transplanted mitochondria around the lesion, thereby improving neurological recovery by supporting
Mi Zhou, Jinhui Zang, Yuxuan Qian, Qiang Zhang, Yifan Wang, Tingting Yao, Hongyu Yan, Kai Zhang, Xiaojun Cai, Lixian Jiang, Yuanyi Zheng   +10 more
wiley   +1 more source

Development and Optimization of Micro‐Nanotopographical Platforms for Surface Enhanced Raman Scattering Biomolecular Detection

Advanced Materials Interfaces, EarlyView.
Lithographically defined concentric micro‐ and nanostructures systematically designed and fabricated as reproducible arrays for Surface‐enhanced Raman spectroscopy applications. Abstract Topologically designed micro‐ and nanostructured surface‐enhanced Raman scattering (SERS) substrates propel the advancements of innovative applications, including ...
David Femi Odetade, Jonathan J. S. Rickard, Pola Goldberg Oppenheimer   +2 more
wiley   +1 more source