Results 91 to 100 of about 15,346 (302)

The Effect of Sialic Acid on MiR-320a and Let-7e Expression in Human Glial Cell Line

open access: yesBasic and Clinical Neuroscience, 2022
Introduction: Sialic acid is pivotal in various critical physiological events at molecular and cellular levels and pathological processes. Changes in sialic acid concentration are observed in many pathological processes; for example, some available data ...
Negar Noorbakhsh   +2 more
doaj  

A 3D Human Neuron‐on‐Chip Platform to Monitor Neuronal Injury Responses

open access: yesAdvanced Healthcare Materials, EarlyView.
This study presents a novel 3D Neuron‐on‐Chip model that can maintain human PSC‐derived excitatory prefrontal cortex neurons in 3D hydrogels and can be used to monitor neuronal injury responses over time. Results show injury‐induced acute neuronal excitotoxicity, declining neuronal connectivity, and the activation of a neurodegenerative, SASP‐like ...
Ruiping Tang   +16 more
wiley   +1 more source

ЗНАЧЕНИЕ МОЗГОВОГО ПЕСКА ЭПИФИЗА И КАЛЬЦИФИКАТОВ В НЕРВНОЙ ТКАНИ В ДИФФЕРЕНЦИАЛЬНОЙ ДИАГНОСТИКЕ ОПУХОЛЕЙ ГОЛОВНОГО МОЗГА

open access: yesCifra: Клиническая медицина
Медиана выживаемости пациентов с опухолями мозга варьирует по данным многих авторов от нескольких месяцев до 5 лет. Методов лечения, ведущих к выздоровлению, на современном этапе не существует.
Рева Г.В.   +11 more
doaj   +1 more source

Flash Assembloids: A Rapid Biofabrication of a Platform for Modeling Early Glioblastoma Invasion at the Glioblastoma–Brain Organoid Interfaces

open access: yesAdvanced Healthcare Materials, EarlyView.
This study presents a bioengineered assembloid (ASM) system combining glioblastoma (GBM) cells in oxidized alginate (OA) microgels with dorsal organoids (DOs). This model simulates brain tumor‐host interactions, revealing enhanced GBM invasion, altered gene expression, and aggressive infiltration patterns, demonstrating ASM as a valuable platform for ...
Chao Liang   +17 more
wiley   +1 more source

Neuroglia and Artificial Intelligence in Pediatric Neurodevelopmental Disorders: Integrating Biological Mechanisms with Precision Diagnostics

open access: yesNeuroglia
Pediatric neurodevelopmental disorders (NDDs) encompass a highly heterogeneous group of conditions characterized by complex interactions among genetic, molecular, developmental, and environmental factors.
Nikola Ilić, Adrijan Sarajlija
doaj   +1 more source

Cellular Responses to Mechanical Cues Across Scales: From Fundamental Insights to Translational Potential

open access: yesAdvanced Healthcare Materials, EarlyView.
This review examines how cellular behavior is regulated by mechanical cues transmitted through soft biomaterials, from single‐cell mechanosensing to tissue‐level adaptation. It highlights why physiological relevance, rather than model complexity alone, is critical for translational mechanobiology and introduces a scoring framework linking material ...
Mathias Polz   +9 more
wiley   +1 more source

Research progress on the effect of hypercholesterolemia on neural function and cerebrovascular disease

open access: yesChinese Journal of Contemporary Neurology and Neurosurgery, 2021
Cholesterol is an essential component for neural physiology. Cholesterol metabolism in brain is independent from that in peripheral tissues due to blood⁃brain barrier (BBB).
ZHUO Jie
doaj  

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