Results 241 to 250 of about 21,722 (324)

Report Of The 12th F.V. Hunt Postdoctoral Fellow (1989-1990) [PDF]

, 1991
Everbach, E. Carr
core   +2 more sources

The tau isoform 1N4R confers vulnerability of MAPT knockout human iPSC‐derived neurons to amyloid beta and phosphorylated tau‐induced neuronal dysfunction

Alzheimer's &Dementia, EarlyView.
Abstract INTRODUCTION Human tau protein, composed of six brain‐specific isoforms, is a major driver of Alzheimer's disease (AD). The role of its isoforms however remains unclear and human AD models are scarce. METHODS We generated human MAPT– (tau–) knockout (KO) induced pluripotent stem cells (iPSC) using CRISPR/Cas9, differentiated these into ...
Sarah Buchholz, Mohamed Aghyad Al Kabbani, Michael Bell‐Simons, Lena Kluge, Cagla Cagmak, Jennifer Klimek, Natja Haag, Lukas C. Iohan, Audrey Coulon, Marcos R. Costa, Devrim Kilinc, Hans Zempel   +11 more
wiley   +1 more source

Cachexia Alters Central Nervous System Morphology and Functionality in Cancer Patients. [PDF]

J Cachexia Sarcopenia Muscle
Simoes E, Uchida R, Nucci MP, Duran FLS, Lima JDCC, Gama LR, Costa NA, Otaduy MCG, Bin FC, Otoch JP, Alcantara P, Ramos A, Laviano A, Diaz MB, Esiri MM, DeLuca GC, Herzig S, Filho GB, Seelaender M.   +18 more
europepmc   +1 more source

Editorial: Women in neuroscience of Bioelectronic Medicine. [PDF]

Front Integr Neurosci
Thébault SC, Tremblay MÈ, Conde SV, González-González MA.   +3 more
europepmc   +1 more source

Sleep disturbance in bipolar disorder:Neuroglia and circadian rhythms [PDF]

, 2019
Carbone, Elvira Anna, De Fazio, Pasquale, De Filippis, Renato, Segura-Garcia, Cristina, Steardo, Luca J., Verkhratsky, Alexei   +5 more
core   +1 more source

Microglial ApoD‐induced NLRC4 inflammasome activation promotes Alzheimer's disease progression

Animal Models and Experimental Medicine, EarlyView.
We found that NLRC4 inflammasome was activated in microglia releasing IL6 and TNF‐α to impair the hippocampal neural stem cells (NSCs) self‐proliferation. ApoD contributed to activating NLRC4 inflammasome in microglia. Targeting the ApoD provides beneficial effects on NSCs self‐proliferation and mature neurons survival.
Yaliang Yu, Jianzhou Lv, Dan Ma, Ya Han, Yaheng Zhang, Shanlong Wang, Zhitao Wang   +6 more
wiley   +1 more source

Transcriptomic signatures of individual cell types in cerebral cavernous malformation. [PDF]

Cell Commun Signal
Li Y, Girard R, Srinath A, Cruz DV, Ciszewski C, Chen C, Lightle R, Romanos S, Sone JY, Moore T, DeBiasse D, Stadnik A, Lee JJ, Shenkar R, Koskimäki J, Lopez-Ramirez MA, Marchuk DA, Ginsberg MH, Kahn ML, Shi C, Awad IA.   +20 more
europepmc   +1 more source

The cumulative analgesic effect of repeated electroacupuncture is modulated by Adora3 in the SCDH of mice with neuropathic pain

Animal Models and Experimental Medicine, EarlyView.
Neuropathic pain management via repeated electroacupuncture. Abstract Background Existing remedial approaches for relieving neuropathic pain (NPP) are challenging and open the way for alternative therapeutic measures such as electroacupuncture (EA). The mechanism underlying the antinociceptive effects of repeated EA sessions, particularly concerning ...
Faisal Ayub Kiani, Hao Li, Panpan Guo, Qiulin Zhang, Mahmoud M. Abouelfetouh, Mingxing Ding, Yi Ding   +6 more
wiley   +1 more source

Alzheimer's Disease, Obesity, and Type 2 Diabetes: Focus on Common Neuroglial Dysfunctions (Critical Review and New Data on Human Brain and Models). [PDF]

Brain Sci
Toledano A, Rodríguez-Casado A, Älvarez MI, Toledano-Díaz A.   +3 more
europepmc   +1 more source

Exploring the co‐morbid relationship between Alzheimer's disease and lung cancer in the 5xFAD transgenic mouse model

Animal Models and Experimental Medicine, EarlyView.
Schematic diagram of inverse comorbidities of Alzheimer's disease and lung cancer. Abstract Background Alzheimer's disease (AD) and lung cancer are leading causes of mortality among the older population. Epidemiological evidence suggests an antagonistic relationship between them, whereby patients with AD exhibit a reduced risk of developing cancer and ...
Mingfeng Li, Xinghan Wu, Lin Jiang, Min Liu, Gong Yanju, Xiaomeng Li, Fan Tian, Fan Ye, Jinlong Wang, Siyuan Wang, Chuan Qin, Ling Zhang   +11 more
wiley   +1 more source