Results 121 to 130 of about 171 (170)

Alpha‐Lipoic Acid Alleviates Isoflurane‐Induced Cognitive Dysfunction in Juvenile Mice by Activating Peroxisome Proliferator Activated Receptor Gamma Coactivator ‐1 Alpha

Food Frontiers, EarlyView.
Alpha‐lipoic acid (ALA) plays a significant role in alleviating isoflurane‐induced cognitive dysfunction in juvenile mice by activating PGC‐1α, which improves mitochondrial function and energy metabolism in astrocytes. As a potent antioxidant, ALA is commonly found in foods like spinach, broccoli, and yeast, and its supplementation may offer ...
Xingkai Zhao, Donglu Wang, Shuai Li, Xueting Zhang, Zhenlei Zhou   +4 more
wiley   +1 more source

Neuroprotective Properties of Wild Mango (Mangifera caloneura Kurz) Leaves on Alleviating Urban Air Pollutant Toxicity: Insights From Transcriptome Analysis of a Human Neuronal Cell Model

Food Frontiers, EarlyView.
ABSTRACT Exposure to urban air pollution, particularly particulate matter (PM), has been correlated with an increased risk of neurodegenerative diseases, notably Alzheimer's and Parkinson's diseases. However, the mechanisms underlying the association between urban air pollution and neurodegenerative diseases remain unclear.
Parinee Kittimongkolsuk, Suporn Sukjamnong, Sakawrat Janpaijit, Panthakarn Rangsinth, Sawarin Chumpolphant, Kamonwan Chaikhong, George Pak‐Heng Leung, Valerie W. Hu, Tewarit Sarachana, Anchalee Prasansuklab, Tewin Tencomnao   +10 more
wiley   +1 more source

Multi‐Cohort Analysis Reveals Genetic Predispositions to Clonal Hematopoiesis as Mutation‐Specific Risk Factors for Stroke

Advanced Genetics, Volume 6, Issue 1, March 2025.
This study comprehensively evaluated the differential effect of clonal hematopoiesis (CH) mutations on the risk of various stroke subtypes and functional recovery. It shows that TET2 is associated with small vessel stroke possibly via a pro‐inflammatory pathway. Abstract Recent observational studies have found an association between Clonal Hematopoesis
Shuyang Lin, Yang E. Li, Yan Wang
wiley   +1 more source

Proteome‐Wide Mendelian Randomization Identifies Candidate Causal Proteins for Cardiovascular Diseases

Advanced Genetics, EarlyView.
Here, causal relations are examined between 2940 plasma proteins and 19 cardiovascular diseases (CVD) using a human genetics‐based method. 218 proteins are found whose blood levels influence CVD risks, with about half being new discoveries and largely confirmed in an independent cohort.
Chen Li, Nicolas De Jay, Shan‐Shan Zhang, Xin Fang, Supriya Sharma, Katrina A. Catalano, Venkatesh Sridharan, Zhaoqing Wang, Lei Zhao, Joseph D. Szustakowski, Ching‐Pin Chang, Joseph C. Maranville, Emily R. Holzinger, Erika M. Kvikstad   +13 more
wiley   +1 more source

Behavioural aspects of neuroinflammation

Behavioural Pharmacology, 2019
Louk J. M. J. Vanderschuren, Jack Bergman, Paul Willner   +2 more
openaire   +3 more sources

FABP7 Expression Modulates the Response of Astrocytes to Induced Endotoxemia

Glia, EarlyView.
FABP7 silencing reduces inflammatory response in astrocytes. FABP7 silencing decreases astrocyte‐mediated neurotoxicity. FABP7 silencing attenuates NF‐κB‐dependent transcriptional response during endotoxemia. ABSTRACT Fatty acid binding proteins (FABPs) are a family of small proteins involved in fatty acid (FA) subcellular trafficking.
Mariana Bresque, Daniel Esteve, Garret Balmer, Haylee L. Hamilton, Joshua S. Stephany, Mariana Pehar, Marcelo R. Vargas   +6 more
wiley   +1 more source

The Aquaporin‐4 Expression and Localization in the Olfactory Epithelium Modulate the Odorant‐Evoked Responses and Olfactory‐Driven Behavior

Glia, EarlyView.
ABSTRACT Aquaporin‐4 (AQP4) is a water‐selective channel expressed in glial cells throughout the central nervous system (CNS). It serves as the primary water channel in the neuropil and plays roles in physiological functions, including regulating water homeostasis by adjusting cell volume and modulating neuronal activity. Different isoforms of AQP4 are
Donatella Lobraico, Pasqua Abbrescia, Maria Grazia Fioriello, Barbara Barile, Claudia Palazzo, Onofrio Valente, Grazia Paola Nicchia, Michele Dibattista, Antonio Frigeri   +8 more
wiley   +1 more source

Subtle Alterations in Hippocampal Neuronal Activity Coincide With Early Sex‐Specific Differences in Amyloidosis and Microglia in a Pre‐Symptomatic Mouse Model of Alzheimer‐Like Pathology

Glia, EarlyView.
In a pre‐symptomatic mouse model of Alzheimer disease, despite higher amyloid‐β load, females display fewer plaques than males. More efficient synaptic transmission as well as less microgliosis point to better early coping with pathogenesis in females.
Thomas Chaigneau, Sha Sha, Candice M. Roux, Saba Aïd, Alice Faucher, Yannick Chantran, Guillaume Dorothée, Slavica Krantic   +7 more
wiley   +1 more source

Microglial IKKβ Alters Central and Peripheral Immune Activity at Distinct Time Points After Spinal Cord Injury

Glia, EarlyView.
Microglial NF‐κB signaling increases M1‐like spinal microglia over time after spinal cord injury. Microglial NF‐κB signaling broadly affects gene expression in spinal cord. Microglial NF‐κB signaling modulates splenocytes acutely after spinal cord injury.
Micaela L. O'Reilly, Mariah J. Wulf, Theresa M. Connors, Ying Jin, Frank Bearoff, Julien Bouyer, Sandhya Kortagere, John R. Bethea, Veronica J. Tom   +8 more
wiley   +1 more source

Spatial Transcriptomic Analysis Reveals HDAC Inhibition Modulates Microglial Dynamics to Protect Against Ischemic Stroke in Mice

Glia, EarlyView.
Spatial transcriptomic analysis unravels the mechanisms by which HDACi ameliorates neuroinflammation and enhances neuroprotection by modulating the expression of microglial transcriptomes in the ischemic mouse brain. ABSTRACT Ischemic stroke significantly contributes to global morbidity and disability through a cascade of neurological responses ...
Kevin Jayaraj, Ritesh Kumar, Sukanya Shyamasundar, Thiruma V. Arumugam, Jai S. Polepalli, S. Thameem Dheen   +5 more
wiley   +1 more source