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BIOCHEMISTRY AND NEUROLOGY: METABOLIC DISORDERS IN DISEASES OF THE CENTRAL NERVOUS SYSTEM

The central nervous system (CNS) is one of the most metabolically active systems in the human body. Proper neuronal function depends on continuous energy production, balanced neurotransmitter metabolism, mitochondrial integrity, and redox homeostasis. Metabolic disturbances can impair neuronal communication, accelerate neurodegeneration, and contribute
Tuychieva Mashhuraxon Alisher qizi   +1 more
openaire   +1 more source

Inflammatory and Autoimmune Central Nervous System Diseases and the Neurology of Sepsis

2016
Headache is considered to be a nearly universal experience. Approximately 98% of the population will experience some form of headache in a lifetime. The number of migraineurs worldwide is approximately 1 billion, and nearly 1 in every 4 households in the United States has at least one family member who experiences migraine.
openaire   +1 more source

The role of secretory phospholipase A₂ in the central nervous system and neurological diseases.

Molecular neurobiology, 2014
Secretory phospholipase A2 (sPLA2s) are small secreted proteins (14-18 kDa) and require submillimolar levels of Ca(2+) for liberating arachidonic acid from cell membrane lipids. In addition to the enzymatic function, sPLA2 can exert various biological responses by binding to specific receptors.
Tatsurou, Yagami   +2 more
openaire   +1 more source

ACSL4-Mediated Ferroptosis and Its Potential Role in Central Nervous System Diseases and Injuries

International Journal of Molecular Sciences, 2023
Chengliang Luo
exaly  

S100-mediated signal transduction in the nervous system and neurological diseases.

Cellular and molecular biology (Noisy-le-Grand, France), 2006
This article presents new information regarding the complement/level of S100 family members expressed in the brain and reviews the contribution of brain S100 family members to nervous system function and disease. A total of ten S100 family members are reported in the literature to be expressed in brain -S100A1, S100A2, S100A4, S100A5, S100A6, S100A10 ...
D B, Zimmer   +3 more
openaire   +1 more source

The glymphatic system: implications for drugs for central nervous system diseases

Nature Reviews Drug Discovery, 2022
Maiken Nedergaard   +2 more
exaly  

Targeting sialylation to treat central nervous system diseases

Trends in Pharmacological Sciences, 2021
Jan Lunemann, Harald Neumann
exaly  

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