Results 121 to 130 of about 540,580 (353)
Do we need broad immunological work-up in all patients with CIS? [PDF]
, 2012 BACKGROUND: The aim of this study was to determine the prevalence of altered immunological tests and their clinical significance in patients with clinically isolated syndrome (CIS) suggestive of multiple sclerosis (MS). ----- PATIENTS AND METHODS:
Adamec, Ivan +6 more
core +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective In multiple sclerosis, the optimal time for deploying a therapeutic intervention is before the central nervous system is damaged; given the success of trials treating the earliest stage of MS, the radiologically isolated syndrome, developing primary prevention strategies is an important next challenge.
Amy W. Laitinen +7 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao +6 more
wiley +1 more source
Jules Joseph Dejerine: an outstanding neurologist and Charcot's enemy
Arquivos de Neuro-PsiquiatriaJules Joseph Dejerine (1849-1917) became renowned for his many contributions to neurology, including his anatomical and anatomo-functional studies, particularly those in the field of language and the peripheral nervous system. A disciple of Vulpian and a
Gustavo Koíti Kondo +3 more
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives Retrograde trans‐synaptic degeneration (rTSD) from posterior visual pathway lesions in multiple sclerosis (MS) is characterized by hemi‐macular ganglion cell‐inner plexiform layer (GCIPL) thinning and contralateral visual field loss.
Abdul Jaber Tayem +17 more
wiley +1 more source
Ecotoxicology and Environmental SafetyThis study applied network toxicology and multimodal biological approaches integrated with machine learning to systematically identify four TCS-IS-related genes, providing a comprehensive understanding of the pathophysiological relationship between ...
Fangyuan Cheng +4 more
doaj +1 more source
Low Incidence of Relapses After Vaccination in Anti‐Aquaporin‐4 Antibody‐Positive NMOSD
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Patients with neuromyelitis optica spectrum disorder (NMOSD) may experience increased signs and symptoms of their underlying disease when vaccinated against meningococcal disease before receiving complement component 5 inhibitor therapies. This retrospective analysis indicated an overall low relapse incidence (mean [range], 3.3% [0.7%–10.6 ...
Sean J. Pittock +4 more
wiley +1 more source
Optimizing filter trap assay for the detection of aggregated alpha-synuclein in brain samples
Free Neuropathology, 2020 Thibauld Oullier +5 more
doaj +1 more source
The Role and Mechanism of Metformin in the Treatment of Nervous System Diseases
BiomoleculesNervous system diseases represent a significant global burden, affecting approximately 16% of the world’s population and leading to disability and mortality.
Hui Li, Ruhui Liu, Junyan Liu, Yi Qu
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To explore how cerebral hypoxia and Normal‐Appearing White Matter (NAWM) integrity affect MS lesion burden and clinical course. Methods Seventy‐nine MS patients, including 13 clinically isolated syndrome (CIS) patients and 66 relapsing–remitting multiple sclerosis (RRMS) patients, and 44 healthy controls (HCs) were recruited from ...
Xinli Wang +8 more
wiley +1 more source