Results 41 to 50 of about 540,580 (353)

Alois Alzheimer and vascular brain disease: Arteriosclerotic atrophy of the brain. [PDF]

, 2015
Alois Alzheimer is best known for his description of neurofibrillary changes in brain neurons of a demented patient, identifying a novel disease, soon named after him by Kraepelin.
Engelhardt, Eliasz, Grinberg, Lea T
core   +2 more sources

Climate change and disorders of the nervous system.

Lancet Neurology
Anthropogenic climate change is affecting people's health, including those with neurological and psychiatric diseases. Currently, making inferences about the effect of climate change on neurological and psychiatric diseases is challenging because of an ...
S. Sisodiya, Medine I. Gulcebi, Francesco Fortunato, James D Mills, E. Haynes, E. Bramon, P. Chadwick, O. Ciccarelli, A. S. David, K. De Meyer, Nick C Fox, Joanna Davan Wetton, Martin Koltzenburg, Dimitri M. Kullmann, M. Kurian, Hadi Manji, M. Maslin, Manjit Matharu, Hugh Montgomery, M. Romanello, D. Werring, Lisa Zhang, K. Friston, Michael G Hanna   +23 more
semanticscholar   +1 more source

Cell-surface central nervous system autoantibodies: Clinical relevance and emerging paradigms

Annals of Neurology, 2014
The recent discovery of several potentially pathogenic autoantibodies has helped identify patients with clinically distinctive central nervous system diseases that appear to benefit from immunotherapy.
S. Irani, J. Gelfand, Adam Al‐Diwani, A. Vincent   +3 more
semanticscholar   +1 more source

Enteric Nervous System and Its Relationship with Neurological Diseases

Journal of Clinical Medicine
The enteric nervous system (ENS) is a fundamental component of the gastrointestinal system, composed of a vast network of neurons and glial cells. It operates autonomously but is interconnected with the central nervous system (CNS) through the vagus nerve.
María José Luesma, Liberto López-Marco, Marta Monzón, Sonia Santander   +3 more
openaire   +4 more sources

Viral vectors in neurodegenerative diseases: immune responses and therapeutic applications

Frontiers in Neurology
Gene transfer-based therapies utilizing viral vectors have undergone remarkable advancements and hold significant promise in addressing neurodegenerative diseases in recent years, whose potential mechanisms include replacing or silencing pathogenic genes
Yifei Wang, Yifei Wang, Yifei Wang, Siyu Mu, Siyu Mu, Siyu Mu, Fangxi Liu, Fangxi Liu, Fangxi Liu   +8 more
doaj   +1 more source

Targeting foam cell formation in inflammatory brain diseases by the histone modifier MS‐275

Annals of Clinical and Translational Neurology, 2020
Objective To assess class I‐histone deacetylase (HDAC) inhibition on formation of lipid‐accumulating, disease‐promoting phagocytes upon myelin load in vitro, relevant for neuroinflammatory disorders like multiple sclerosis (MS) and cerebral X‐linked ...
Bettina Zierfuss, Isabelle Weinhofer, Agnieszka Buda, Niko Popitsch, Lena Hess, Verena Moos, Simon Hametner, Stephan Kemp, Wolfgang Köhler, Sonja Forss‐Petter, Christian Seiser, Johannes Berger   +11 more
doaj   +1 more source

Poor Outcome in a Mitochondrial Neurogastrointestinal Encephalomyopathy Patient with a Novel TYMP Mutation: The Need for Early Diagnosis. [PDF]

, 2012
Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is a devastating autosomal recessive disorder due to mutations in TYMP, which cause loss of function of thymidine phosphorylase (TP), nucleoside accumulation in plasma and tissues and ...
Bax, BE, Bereczki, C, Buono, R, Filosto, M, Padovani, A, Russignan, A, Scarpelli, M, Tonin, P, Zappini, F, Zombor, M   +9 more
core   +3 more sources

Neuroimmune crosstalk in the central nervous system and its significance for neurological diseases [PDF]

Journal of Neuroinflammation, 2012
The central nervous system (CNS) is now known to actively communicate with the immune system to control immune responses both centrally and peripherally. Within the CNS, while studies on glial cells, especially microglia, have highlighted the importance of this cell type in innate immune responses of the CNS, the immune regulatory functions of other ...
Ma Li, Tian Li, Kaarela Tiina, Li Zhilin   +3 more
openaire   +4 more sources

Cerebrospinal Fluid Concentrations of the Synaptic Marker Neurogranin in Neuro-HIV and Other Neurological Disorders. [PDF]

, 2019
Purpose of reviewThe aim of this study was to examine the synaptic biomarker neurogranin in cerebrospinal fluid (CSF) in different stages of HIV infection and in relation to what is known about CSF neurogranin in other neurodegenerative diseases.Recent ...
Blennow, Kaj, Fuchs, Dietmar, Gisslén, Magnus, Price, Richard W, Spudich, Serena, Yilmaz, Aylin, Zetterberg, Henrik   +6 more
core   +2 more sources

Repopulation of microglia and its implications for CNS disorders: Insights from the single-cell era

Neurobiology of Disease
Microglia, as resident macrophages in the central nervous system (CNS), have been the focus of the scientific community. The pace of exploration in the origin and development of microglia, though tortuous, never stops.
Cong Chen, Guanjia Qiao, Dantong Tang, Fengling Xu, Jiawen Dong, Jinpan Zhang, Boru Jin   +6 more
doaj   +1 more source