Results 171 to 180 of about 115,230 (317)
Resolution of generalized tonic seizures following focal ablative or resective surgery
Epileptic Disorders, EarlyView.Abstract Objective Focal brain lesions may underlie generalized tonic seizures, as seen in Lennox–Gastaut syndrome, by engaging bilateral neural networks. However, this seizure type is often not considered surgically remediable. Here, we describe the resolution of apparent electroclinically classic generalized tonic seizures in children originating ...
Sem L. Kampman +3 more
wiley +1 more source
Epileptic Disorders, EarlyView.Abstract Epilepsy surgery remains the most effective treatment for focal drug‐resistant epilepsy, and stereoelectroencephalography (SEEG) is increasingly used to define the epileptogenic‐zone network (EZN) and guide curative or palliative interventions.
Ionuț‐Flavius Bratu +4 more
wiley +1 more source
A guide to neuromodulation in drug‐resistant epilepsy
Epileptic Disorders, EarlyView.Abstract Neuromodulation is approved for the treatment of drug‐resistant epilepsy. It has been increasingly utilized over the past two decades with the approval of deep brain stimulation (DBS) and responsive neurostimulation (RNS) in addition to vagus nerve stimulation (VNS)—particularly in patients who are not deemed to be good resective surgical ...
Prachi Parikh +10 more
wiley +1 more source
Cardiorespiratory cross‐frequency coupling biomarker for sudden unexpected death in epilepsy
Epilepsia, EarlyView.Abstract Objective Sudden unexpected death in epilepsy (SUDEP) often follows generalized tonic–clonic seizures during sleep, likely resulting from impaired brainstem cardiorespiratory function. We used ictal electrocardiogram (ECG)‐based cross‐frequency phase–amplitude coupling (PAC) to detect cardiorespiratory disruptions, comparing SUDEP to non‐SUDEP
Adam C. Gravitis +7 more
wiley +1 more source
Epilepsia, EarlyView.Abstract Objective Antiseizure medications are approved based on clinical trials that demonstrate their efficacy as measured by reductions in seizure frequency (SF). When designing these trials, trialists must select inclusion criteria where SF can be reliably measured to maintain statistical power.
Wesley T. Kerr +6 more
wiley +1 more source
Epilepsia, EarlyView.Abstract Objective The thalamus is a key hub in seizure propagation, and its nuclei are emerging targets for neuromodulation. However, the contributions of individual nuclei to epileptic networks remain unclear, particularly in children, who are less studied than adults.
Xiyu Feng +11 more
wiley +1 more source
Epilepsia, EarlyView.Abstract High‐frequency oscillations (HFOs) were discovered more than 20 years ago, and since then they have been studied intensively in the context of epilepsy. HFOs encompass a broad spectrum of oscillations, typically ranging from 80 Hz to several kHz, that include both normal and pathological oscillations, documented in people with epilepsy and ...
Christos Panagiotis Lisgaras +6 more
wiley +1 more source
Epilepsia, EarlyView.Abstract Objective This work was undertaken to study the association between vagus nerve stimulation (VNS) parameters and the apnea–hypopnea index (AHI) measured by polysomnography in patients with drug‐resistant epilepsy. Methods Patients with epilepsy who underwent polysomnography with an active VNS device between 2018 and 2023 were retrospectively ...
Jacques‐François Massa +8 more
wiley +1 more source