Results 11 to 20 of about 7,807 (215)

Functional connectivity response to acute pain assessed by fNIRS is associated with BDNF genotype in fibromyalgia: an exploratory study

Scientific Reports, 2022
Fibromyalgia is a heterogenous primary pain syndrome whose severity has been associated with descending pain modulatory system (DPMS) function and functional connectivity (FC) between pain processing areas.
Álvaro de Oliveira Franco, Guilherme de Oliveira Venturini, Camila Fernanda da Silveira Alves, Rael Lopes Alves, Paul Vicuña, Leticia Ramalho, Rafaela Tomedi, Samara Machado Bruck, Iraci L. S. Torres, Felipe Fregni, Wolnei Caumo   +10 more
doaj   +1 more source

Optimised transcranial direct current stimulation (tDCS) for fibromyalgia—targeting the endogenous pain control system: a randomised, double-blind, factorial clinical trial protocol

BMJ Open, 2019
Introduction Fibromyalgia (FM) is a common debilitating condition with limited therapeutic options. Medications have low efficacy and are often associated with adverse effects.
Luis Castelo-Branco, Elif Uygur Kucukseymen, Dante Duarte, Mirret M El-Hagrassy, Camila Bonin Pinto, Muhammed Enes Gunduz, Alejandra Cardenas-Rojas, Kevin Pacheco-Barrios, Yiling Yang, Paola Gonzalez-Mego, Anayali Estudillo-Guerra, Ludmilla Candido-Santos, Ines Mesia-Toledo, Haley Rafferty, Wolnei Caumo, Felipe Fregni   +15 more
doaj   +1 more source

Connectivity‐based selection of optimal deep brain stimulation contacts: A feasibility study

Annals of Clinical and Translational Neurology, 2019
Background The selection of optimal deep brain stimulation (DBS) parameters is time‐consuming, experience‐dependent, and best suited when acute effects of stimulation can be observed (e.g., tremor reduction).
Vibhor Krishna, Francesco Sammartino, Qinwan Rabbani, Barbara Changizi, Punit Agrawal, Milind Deogaonkar, Michael Knopp, Nicole Young, Ali Rezai   +8 more
doaj   +1 more source

Objective wearable measures correlate with self-reported chronic pain levels in people with spinal cord stimulation systems

npj Digital Medicine, 2023
Spinal Cord Stimulation (SCS) is a well-established therapy for treating chronic pain. However, perceived treatment response to SCS therapy may vary among people with chronic pain due to diverse needs and backgrounds.
Denis G. Patterson, Derron Wilson, Michael A. Fishman, Gregory Moore, Ioannis Skaribas, Robert Heros, Soroush Dehghan, Erika Ross, Anahita Kyani   +8 more
doaj   +1 more source

Neurotransmitters and Neuromodulators [PDF]

Acta geneticae medicae et gemellologiae, 1974
In the central nervous system, besides the neurotransmitters, the occurrence of substances which modify neuronal excitability has been proposed. Since their effect is a matter of modulating neuronal responsiveness, these substances may be called neuromodulators.Examples of neurotransmitters or putative neurotransmitters in the central nervous system ...
openaire   +1 more source

Searching for the optimal tDCS target for motor rehabilitation

Journal of NeuroEngineering and Rehabilitation, 2019
Background Transcranial direct current stimulation (tDCS) has been investigated over the years due to its short and also long-term effects on cortical excitability and neuroplasticity.
Isadora Santos Ferreira, Beatriz Teixeira Costa, Clara Lima Ramos, Pedro Lucena, Aurore Thibaut, Felipe Fregni   +5 more
doaj   +1 more source

Digital Health Integration With Neuromodulation Therapies: The Future of Patient-Centric Innovation in Neuromodulation

Frontiers in Digital Health, 2021
Digital health can drive patient-centric innovation in neuromodulation by leveraging current tools to identify response predictors and digital biomarkers.
Yagna J. Pathak, Walter Greenleaf, Leo Verhagen Metman, Pieter Kubben, Sridevi Sarma, Brian Pepin, Douglas Lautner, Scott DeBates, Alex M. Benison, Binesh Balasingh, Erika Ross   +10 more
doaj   +1 more source

Sensory Neuromodulation [PDF]

Frontiers in Systems Neuroscience, 2018
We describe a model of neurological disease based on dysfunctional brain oscillators.  This is not a new model, but it is not one that is generally appreciated by clinicians.  The value of this model lies in the predictions it makes and the utility it provides in translational applications, in particular for neuromodulation devices ...
Robert D. Black, Lesco L. Rogers
openaire   +3 more sources

Natural Frequencies of Levodopa‐Induced Dyskinesia in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Abnormal involuntary movements, known as dyskinesias, are common complications of levodopa treatment in patients with Parkinson's disease and can significantly impair quality of life. The underlying pathophysiology remains unclear, and current therapeutic options are limited.
Ioannis U. Isaias, Federica Avantaggiato, Gianni Pezzoli, Andrea Canessa   +3 more
wiley   +1 more source

Development of a remote therapeutic monitoring platform: applications for movement disorders

Scientific Reports
Digital health tools are emerging as a promising solution for optimizing Deep Brain Stimulation (DBS) therapy for neurodegenerative diseases such as Parkinson’s Disease (PD), addressing challenges of therapy maintenance, care access, and discrete ...
Sreetharan Thankathuraipandian, Walter Greenleaf, Anahita Kyani, Tucker Tomlinson, Binesh Balasingh, Erika Ross, Yagna Pathak   +6 more
doaj   +1 more source