Results 291 to 300 of about 113,820 (381)

The Second Hit Hypothesis in Animal and Human Dystonia: The Role of Peripheral Nerve Trauma and Spinal Cord Injury

open access: yesMovement Disorders, EarlyView.
The “second‐hit” hypothesis proposes that both a genetic predisposition and an environmental insult—such as peripheral nerve trauma or spinal cord injury—are required for dystonia development. This review explores how neuroinflammation and maladaptive plasticity, triggered by nerve and spinal cord injury, contribute to dystonia pathogenesis.
Lisa Harder‐Rauschenberger   +1 more
wiley   +1 more source

Comorbid Obsessive Compulsive Disorder in Tourette's Syndrome: Questioning its Impact

open access: yes
Movement Disorders Clinical Practice, EarlyView.
Lyna Hanafi, Marc E. Lavoie
wiley   +1 more source

A Network Centered on the Visual‐Motor Cortex Is Critically Involved in Postural Abnormality in Parkinson's Disease

open access: yesMovement Disorders, EarlyView.
Abstract Background Postural abnormality (PA) is a key motor symptom in Parkinson's disease (PD) that leads to disability and death. However, the pathophysiology underlying PA is still unknown. Objective The objective of this study was to explore the neural patterns behind PAs and measures toward functional restoration using repetitive transcranial ...
Zhuang Wu   +9 more
wiley   +1 more source

Feasibility of Simon Two‐Stage Futility Trials in People with Early, Symptomatically Treated Parkinson's Disease

open access: yesMovement Disorders, EarlyView.
Abstract Background Disease‐modifying treatments are a critical unmet need in Parkinson's disease (PD). Phase 2 futility trials using the Simon two‐stage design offer an efficient strategy to evaluate candidate treatments in an early PD population. Objective The aim was to assess the feasibility of Simon two‐stage futility trials in early, levodopa ...
Marcus W. Koch   +12 more
wiley   +1 more source

Transcranial Ultrasound Stimulation of Internal Globus Pallidus Region and Motor Cortex in Parkinson's Disease

open access: yesMovement Disorders, EarlyView.
Abstract Background Many patients with Parkinson's disease (PD) have motor impairments despite dopaminergic therapy. Low‐intensity transcranial ultrasound stimulation (TUS) is a non‐invasive neuromodulation method with high spatial precision. The effects of motor cortex (M1) and internal globus pallidus (GPi) TUS on PD motor signs and cortical ...
Yi‐Ying Lin   +8 more
wiley   +1 more source

Thalamocortical network neuromodulation for epilepsy. [PDF]

open access: yesBrain Commun
Agashe S   +12 more
europepmc   +1 more source

MR‐ARFI to evaluate intensity variability and enhance targeting of FUS: A brain study in rats

open access: yesMagnetic Resonance in Medicine, EarlyView.
Abstract Purpose Inconsistencies in focused ultrasound (FUS) transducer positioning and skull‐induced aberrations can reduce the targeting accuracy and cause inconsistencies in the intensity delivered during FUS neuromodulation procedures. This study aimed to evaluate the use of MR‐acoustic radiation force imaging (MR‐ARFI) in improving the targeting ...
Abubakr Eldirdiri   +7 more
wiley   +1 more source

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