Results 271 to 280 of about 3,364,352 (377)

Nuclear Import Defects Drive Cell Cycle Dysregulation in Neurodegeneration

open access: yesAging Cell, EarlyView.
Overview of Dysregulated Cell Cycle Mechanisms in Neuronal Cells. A nuclear import block drives cell cycle re‐entry from G0, culminating in cell cycle arrest at G1/S. This cell cycle arrest is associated with activation of CKIs from the INK locus (p15, p16, p18, p19) and Cip/Kip (p21, p27) which act on specific CDK/Cyclin complexes.
Jonathan Plessis‐Belair   +3 more
wiley   +1 more source

ElixirSeeker: A Machine Learning Framework Utilizing Fusion Molecular Fingerprints for the Discovery of Lifespan‐Extending Compounds

open access: yesAging Cell, EarlyView.
ElixirSeeker is a machine learning architecture based on a phenotype‐driven drug discovery approach to screen lifespan‐extending compounds. By integrating molecular fingerprints, ElixirSeeker could maximize feature capture of lifespan‐extending compounds.
Yan Pan   +15 more
wiley   +1 more source

A case of silent myasthenia gravis with bilateral vocal cord paralysis' onset after thyroidectomy. [PDF]

open access: yesInt J Surg Case Rep
Donniacuo A   +5 more
europepmc   +1 more source

Calabadion: A New Agent to Reverse the Effects of Benzylisoquinoline and Steroidal Neuromuscular-blocking Agents

open access: yesAnesthesiology, 2013
Ulrike Hoffmann   +8 more
semanticscholar   +1 more source

Fatal drug overdoses in healthcare workers: A thematic framework analysis of coroner reports

open access: yesAddiction, EarlyView.
Abstract Background and aims Healthcare workers face specific vulnerabilities for drug overdose due to their unique access to medications, clinical knowledge and work‐related stress. This study aimed to understand the characteristics of fatal overdoses in healthcare workers with a view to providing guidance for preventative strategies.
Thikra Algahtani   +6 more
wiley   +1 more source

Sugammadex for Reversal of Neuromuscular Blockade in Neonates and Infants Less than 2 Years Old: Results from a Phase IV Randomized Clinical Trial. [PDF]

open access: yesAnesthesiology
Mensah-Osman E   +10 more
europepmc   +1 more source

Acute onset neurological deficits and hypocalcaemia associated with nutritional secondary hyperparathyroidism in three juvenile servals (Leptailurus serval)

open access: yesAustralian Veterinary Journal, EarlyView.
Nutritional secondary hyperparathyroidism is a metabolic disorder caused by an imbalance in calcium homeostasis and is typically associated with the feeding of a calcium‐deficient diet. Nutritional secondary hyperparathyroidism has been reported in domestic species, including cats and dogs, as well as captive carnivores and wildlife including lions ...
JL Austen   +5 more
wiley   +1 more source

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