Results 251 to 260 of about 47,410 (348)

The neuropharmacology of baclofen [PDF]

open access: yes, 1988
AI Shapovalov   +104 more
core   +1 more source

A computational tool to optimize clinical trial parameter selection in Duchenne muscular dystrophy: A practical guide and case studies

open access: yesCPT: Pharmacometrics &Systems Pharmacology, EarlyView.
Abstract Duchenne muscular dystrophy (DMD), a rare pediatric disease, presents numerous challenges when designing clinical trials, mainly due to the scarcity of available trial participants and the heterogeneity of disease progression. A quantitative clinical trial simulator (CTS) has been developed based on previously published five disease ...
Jordan Wilk   +18 more
wiley   +1 more source

ANTAGONISM OF NEUROMUSCULAR BLOCKADE

open access: yesBritish Journal of Anaesthesia, 1985
S.W. Millar, C.J. Lamb, J.B. Liban
openaire   +2 more sources

Review of published research on primary dysautonomia of domestic animals

open access: yesVeterinary Record, EarlyView.
Abstract An article published in 1992 by Marion M. Pollin and I.R. Griffiths reviewed the topic of primary dysautonomias of the autonomic nervous system of unidentified origin in multiple domestic species, specifically cats, dogs and horses. Thirty‐one years later, we appear no closer to identifying the causal agents of these strikingly similar ...
Tanith Harte   +3 more
wiley   +1 more source

Effect of Volatile Anesthetics on Vecuronium-Induced Neuromuscular Blockade in Children

open access: bronze, 1990
Jean‐François Pittet   +5 more
openalex   +1 more source

Targeting the SOD1‒MMP‐2‒COLXVII axis: A therapeutic strategy for age‐related tissue degeneration

open access: yesVIEW, EarlyView.
Our work identifies a novel role for MMP‐2 in driving senescence‐associated skin and muscle degeneration through ECM degradation. We demonstrate that inhibiting MMP‐2 activity restores tissue integrity by preserving COLXVII, revealing a new therapeutic pathway for combating oxidative stress‐induced tissue aging. Using both mammalian and nematode models,
Juewon Kim   +8 more
wiley   +1 more source

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