Results 161 to 170 of about 19,227 (236)

Mechanism‐Informed Pharmacotherapy Optimization and Deprescribing: A Redox–Mitochondrial Framework

open access: yesPharmacology Research &Perspectives, Volume 14, Issue 5, October 2026.
From cumulative drug burden to mitochondrial stress and functional decline. The graphical abstract summarizes the central concept of the review, illustrating how cumulative pharmacotherapy exposure may contribute to redox–mitochondrial stress and thereby reduce biological and functional resilience.
Boštjan Martinc
wiley   +1 more source

The prevalence of genetic variants of the Mas-related G-protein-coupled receptor X2 in patients does not explain perioperative hypersensitivity reactions to neuromuscular blocking agents. [PDF]

open access: yesFront Pharmacol
Dziadowiec A   +10 more
europepmc   +1 more source

Cannabinoid CB1 allosteric ligands suppress inflammatory pain in male mice without tolerance, motor impairment, memory deficits or respiratory depression

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 20, Page 6132-6153, October 2026.
Abstract Background and Purpose Positive allosteric modulators (PAMs) engage sites distinct from the orthosteric CB1 cannabinoid receptor binding site. GAT211, a racemic ligand, contains GAT228 (R) and GAT229 (S) enantiomers. Whether enantiomer‐mediated differences in allosteric activation or positive allosteric modulation translate into differences in
Ifeoluwa D. Solomon   +3 more
wiley   +1 more source

Association Between Neuromuscular Blocking Agents and Outcomes of Emergency Tracheal Intubation: A Secondary Analysis of Randomized Trials. [PDF]

open access: yesAnn Emerg Med
DeMasi SC   +50 more
europepmc   +1 more source

Urgent intubation without neuromuscular blocking agents and the risk of tracheostomy. [PDF]

open access: yesIntern Emerg Med, 2020
Fujinaga J   +4 more
europepmc   +1 more source

Huangqi Guizhi Wuwu Decoction Ameliorates Cachexia in Lung Cancer Mice Through Regulating Amino Acid Metabolism: Insights From Transcriptomics, Metabolomics and Experimental Validation

open access: yesJournal of Cellular and Molecular Medicine, Volume 30, Issue 19, October 2026.
ABSTRACTThe effects and mechanisms of Huangqi Guizhi Wuwu Decoction (HGWD) in cancer cachexia remain unclear. We generated an in vivo cachexia model by implanting Lewis lung carcinoma cells into mice and treated animals with HGWD. We evaluated muscle function using grip strength and wire‐grip tests.
Yingjia Zhou   +9 more
wiley   +1 more source

Three‐Dimensional Assessment of Upper Airway Morphology and Sleep‐Disordered Breathing Risk in Unilateral Craniofacial Microsomia: A Pilot Study

open access: yesOrthodontics &Craniofacial Research, Volume 29, Issue 5, Page 926-936, October 2026.
ABSTRACT Objective Unilateral craniofacial microsomia (UCM) presents varying unilateral deficiencies of the temporomandibular joint, mandibular ramus, masticatory muscles, and adjacent soft tissues and ear. Reduced mandibular and maxillary dimensions may decrease upper airway volume and may increase the risk of sleep‐disordered breathing (SDB).
Akila Aiyar   +3 more
wiley   +1 more source

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