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Neuromuscular blocking agents and reversal agents

Anaesthesia & Intensive Care Medicine, 2011
Abstract The neuromuscular junction consists of the motor nerve terminal, the synaptic cleft and post-synaptic nicotinic receptors on the motor end-plate of striated muscle. Neuromuscular blocking drugs are categorized into depolarizing and non-depolarizing agents.
Khorat Farooq   +3 more
openaire   +2 more sources

Neuromuscular Blocking Agents

Journal of Pharmacy Practice, 1994
Neuromuscular blocking (NMB) agents are frequently used in the operating room (OR) as well as the intensive care units. The number of NMB agents available for use in these areas continues to increase. The clinician currently has 10 agents from which to choose, with another (rocuronium) soon to be available.
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LITHIUM CARBONATE AND NEUROMUSCULAR BLOCKING AGENTS

Survey of Anesthesiology, 1977
The effects of lithium carbonate on the responses to five neuromuscular blocking agents were evaluated in dogs anesthetized with halothane (1 per cent) and N2O (60 per cent) in O2. Latency (time from first twitch-height depression to maximal blockade), maximal twitch-height depression, and times to return to 50 per cent and 100 per cent control twitch ...
Gary E. Hill   +2 more
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Neuromuscular Blocking Agents

2012
The effect of different antiepileptic drugs on the pharmacokinetics of various neuromuscular blocking agents including atracurium, cisatracurium, doxacurium, mivacurium, pancuronium, pipecuronium, rapacuronium, rocuronium and vecuronium are described. Also, potential pharmacodynamic interactions are highlighted.
Philip N. Patsalos, Philip N. Patsalos
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Neuromuscular Blocking Agents

1990
In animal experiments succinylcholine increases ICP (Cottrell et al. 1983, Lanier et al. 1986). The increase in ICP is also observed after pre-treatment with thiopentone (Thiagarajah et al. 1988). In dogs subjected to succinylcholine injection, CBF increases within a few minutes and this hyperperfusion is accompanied by EEG activation (Mori et al. 1973,
Georg E. Cold, Jörn Bo Madsen
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The Danger With Neuromuscular Blocking Agents

Journal of Emergency Nursing, 2004
Susan Paparella, Ches-mont Chapter, is Director for Consulting Services,Institute for Safe Medication Practices (ISMP*), Huntingdon Valley, Pa, and a member of ENA’s ED Safety Workgroup. For reprints, write: Susan Paparella, RN, MSN, 1800 Byberry Rd, Suite 800, Huntingdon Valley, PA 19006; E-mail: spaparella@ismp.org. J Emerg Nurs 2004;30:250-2.
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The history of neuromuscular blocking agents

Current Anaesthesia & Critical Care, 2000
Abstract Muscle relaxants play an important role in anaesthesia. Although the paralysing effect of some Indian poisons had been originally described in the 16th century, the active alkaloids of curare were only discovered early in the 20th century. The paralysing effect was first used for clinical purposes outside anaesthesia and surgery in the 18th ...
Pollard, Brian, Booij, H. H D J
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Neuromuscular blocking and reversal agents

Anaesthesia & Intensive Care Medicine, 2008
Abstract The neuromuscular junction consists of the motor nerve terminal, the synaptic cleft and post-synaptic nicotinic receptors on the motor end-plate of striated muscle. Neuromuscular blocking drugs are categorized into depolarizing and non-depolarizing agents.
Khorat Farooq, Jennifer M. Hunter
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Hypersensitivity Reactions to Neuromuscular Blocking Agents

Current Pharmaceutical Design, 2008
Neuromuscular blocking agents are the leading drugs responsible for immediate hypersensitivity reactions during anaesthesia. Most hypersensitivity reactions represent IgE-mediated allergic reactions. Their incidence is estimated to be between 1 in 3,000 to 1 in 110,000 general anaesthetics. However striking variations have been reported among countries.
H. Bouaziz   +9 more
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Neuromuscular Blocking Agents in ARDS

New England Journal of Medicine, 2010
In this issue of the Journal, Papazian and colleagues1 present intriguing results of their study examining neuromuscular blockade in patients with severe, early acute respiratory distress syndrome (ARDS). The investigators randomly assigned 340 patients to receive the neuromuscular blocking agent cisatracurium or placebo for a period of 48 hours.
openaire   +3 more sources

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