Results 231 to 240 of about 18,575 (296)

Age‐Associated Dysregulation of Postsynaptic Mitochondria Perturbs Reinnervation Kinetics

Aging Cell, Volume 25, Issue 1, January 2026.
We show that aging results in postsynaptic mitochondrial loss at the neuromuscular junction and impaired muscle reinnervation. In vivo CRISPR knockout of mitochondrial genes, CHCHD10 and CHCHD2, in young muscles led to fragmented endplates, aberrant innervation, and impaired transcriptional maturation of sub‐synaptic myonuclei during regeneration ...
Steve D. Guzman, Paula M. Fraczek, Klimentini Itsani, Esraa K. Furati, Devin Juros, Grace Kenney, Gregorio Valdez, Joe V. Chakkalakal, Carlos A. Aguilar   +8 more
wiley   +1 more source

Myasthenia Gravis Outcomes After Use of Statins and Other Contraindicated Treatments: Results From the French National Insurance Database

European Journal of Neurology, Volume 33, Issue 1, January 2026.
In this real‐world study among 14,459 adults with MG, exposure to any contraindicated treatment was not significantly associated with risk of ICU admission for MG but was associated with significantly higher risk of death. In contrast, statins were associated with a greater risk of ICU admission but a lower risk of death.
Guilhem Solé, Jean Philippe Camdessanché, Shahram Attarian, Mariana Ciumas, Cécile Blein, Benjamin Grenier, Eléonore Herquelot, Andoni Echaniz‐Laguna   +7 more
wiley   +1 more source

Motor pathway evaluation by transcranial magnetic stimulation in Swedish horses with acquired equine polyneuropathy

Equine Veterinary Journal, Volume 58, Issue 1, Page 115-124, January 2026.
Abstract Background Acquired equine polyneuropathy in Nordic horses (AEP) is the most prevalent equine polyneuropathy in Norway, Sweden, and Finland and is characterised by pelvic limb knuckling due to metatarsophalangeal extension dysfunction.
Anna May, Siv Hanche‐Olsen, Lutz S. Goehring, Kaspar Matiasek, Karin Hultin Jäderlund, Yury Zablotski, Gittan Gröndahl   +6 more
wiley   +1 more source

Further Insights Into Anticholinergic Action Informed by Japanese Anticholinergic Risk Scale

Geriatrics &Gerontology International, Volume 26, Issue 1, January 2026.
ABSTRACT The increased anticholinergic burden caused by medications in older adults is one of the adverse drug reactions of particular concern, as it can exacerbate the onset of geriatric syndromes or induce cognitive dysfunction, and is also related to the issue of polypharmacy.
Masaki Mogi, Shuang Liu, Yasuyuki Suzuki, Yuuka Shibata, Shizuo Yamada   +4 more
wiley   +1 more source

New cases of δ‐aminolevulinic acid dehydratase deficiency: Functional insights into gene variants using an innovative mouse liver model

Journal of Internal Medicine, Volume 299, Issue 1, Page 126-142, January 2026.
Abstract Background Dysfunction of δ‐aminolevulinic acid dehydratase (ALAD), the second enzyme involved in heme biosynthesis, leads to two pathologies: genetic and acquired. The genetic form is an ultrarare, severe childhood‐onset disease inherited in an autosomal recessive manner, whereas the acquired form usually affects adults due to enzyme ...
Elena Di Pierro, Isabel Solares, Daniel Jericó, Francisco J. Castelbón, Javier Tomás Solera, Antoni Riera‐Mestre, María Barreda‐Sánchez, Carlo Poci, Annamaria Nicolli, Francesco Urigo, Ana Sampedro, Rafael Enríquez de Salamanca, Matteo Marcacci, Matías A. Ávila, Pauline Harper, Marta G. Fanlo‐Maresma, Encarna Guillén‐Navarro, Giovanna Graziadei, Andrea Wenzel, Bodo B. Beck, Paolo Ventura, Montserrat Morales‐Conejo, Antonio Fontanellas   +22 more
wiley   +1 more source

Clinical Trial: Efficacy and Safety of Velusetrag in Chronic Intestinal Pseudo‐Obstruction: A Randomized, Phase 2, Placebo‐Controlled, Crossover, Multiple (n = 1), Proof‐of‐Concept Study

Neurogastroenterology &Motility, Volume 38, Issue 1, January 2026.
This phase 2 proof‐of‐concept trial evaluated the efficacy and safety of velusetrag in patients with chronic intestinal pseudo‐obstruction. Velusetrag treatment was generally well tolerated and was associated with improved symptoms and a reduction in pseudo‐obstructive episodes versus placebo, although these differences did not reach statistical ...
Carolina Malagelada, Roberto De Giorgio, Rosanna Francesca Cogliandro, Luis Alcalá‐González, Anna Costanzini, Valeria Scuderi, Sara Manzoni, Elena Pasquali, Jan Tack, Vincenzo Stanghellini   +9 more
wiley   +1 more source

Intestinal and Multivisceral Transplantation: Where We Stand Today

Pediatric Transplantation, Volume 30, Issue 1, January 2026.
ABSTRACT Intestinal and multivisceral transplantation has evolved from an experimental to a life‐saving procedure for children and adults with complications of gut failure (GF). Suboptimal long‐term outcomes of transplant elicit recent advances in surgical and medical gut rehabilitation along with the introduction of glucagon‐like peptide‐2 (GLP‐2 ...
Mohamed Maklad, Mohammed Osman, Mariam Ismail, Tetsuya Tajima, Kadakkal Radhakrishnan, Masato Fujiki   +5 more
wiley   +1 more source

Welfare Indicators for Aquaculture Research: Toolboxes for Five Farmed European Fish Species

Reviews in Aquaculture, Volume 18, Issue 1, January 2026.
ABSTRACT Refining approaches to measuring, monitoring and appraising animal welfare in aquaculture research is key to (i) protecting and optimizing it, (ii) documenting the severity of how and when it deviates, and (iii) ensuring good scientific quality, reliable results and reproducibility, amongst other factors.
Chris Noble, Wout Abbink, René Alvestad, László Ardó, Marie‐Laure Bégout, Nina Bloecher, Erik Burgerhout, Josep Calduch‐Giner, Mauro Chivite‐Alcalde, Petr Císař, Evan Durland, Åsa M. Espmark, Lynne Falconer, Martin Føre, Dimitra G. Georgopoulou, Karsten Heia, Gaute A. N. Helberg, David Izquierdo Gomez, Lill‐Heidi Johansen, Gunhild Seljehaug Johansson, Kristbjörg Edda Jónsdóttir, Jelena Kolarevic, Aleksei Krasnov, Santhosh K. Kumaran, Bjarne Kvæstad, Thomas Larsson, Carlo C. Lazado, Angelico Madaro, Federico Moroni, Ingrid Måge, Jonatan Nilsson, Samuel Ortega, Nikos Papandroulakis, Jaume Pérez‐Sánchez, Pamela M. Prentice, Sonia Rey Planellas, Bjørn Roth, Adrian Smith, Lars Erik Solberg, Orestis Stavrakidis‐Zachou, Lars Helge Stien, Anja Striberny, Ragnhild Aven Svalheim, Bjørn‐Steinar Sæther, Gerrit Timmerhaus, Hilde Toften, Linda Tschirren, Hans van de Vis, Elisabeth Ytteborg, Lucas A. Zena, Tone‐Kari Knutsdatter Østbye   +50 more
wiley   +1 more source

Chimeric Antigen Receptor T‐Cell Therapy: More Than an Anti‐Cancer Drug

HLA, Volume 107, Issue 1, January 2026.
ABSTRACT Initially, chimeric antigen receptor (CAR) T‐cell therapy was developed to eliminate malignant B cells in haematological B‐cell malignancies by targeting CD19 and B‐cell maturation antigen. This approach achieved notable success, resulting in (malignant) B‐cell depletion and inducing clinical remission in cancer patients.
Hannah C. M. Schenk, Ilse Gille, Carolt Arana, Jordi Rovira, Eduard Palou, Fritz Diekmann, Dave L. Roelen, Mirjam H. M. Heemskerk, Sebastiaan Heidt   +8 more
wiley   +1 more source