Results 81 to 90 of about 1,286,377 (194)

Voltage‐gated potassium channels mediate thyroid hormone control of skeletal muscle excitability

The Journal of Physiology, EarlyView.
Abstract figure legend Thyroid hormone (TH)‐dependent remodelling of potassium (K+) channel networks regulates skeletal muscle (SkM) excitability. Triiodothyronine (T3), locally generated from thyroxine (T4) by type 2 deiodinase (D2), binds thyroid hormone receptors (TRα/β) and modulates transcription via thyroid response elements (TREs).
Annarita Nappi, Caterina Miro, Annunziata Gaetana Cicatiello, Ilaria Piccialli, Serena Sagliocchi, Lucia Acampora, Federica Restolfer, Rosa Sirica, Melania Murolo, Emery Di Cicco, Daniela Terracciano, Anna Pannaccione, Monica Dentice   +12 more
wiley   +1 more source

Cholinesterase deficiency and anesthesia management: Clinical challenges and coping strategies

Journal of Family Medicine and Primary Care
Cholinesterase deficiency is a rare genetic disorder that impairs the activity of acetylcholinesterase and butyrylcholinesterase. It causes severe perioperative risks due to prolonged neuromuscular blockade induced by succinylcholine and ester-based ...
Tiantian Liu, Chaofeng Sun, Song Ye, Qinsong Ye, Ding Li   +4 more
doaj   +1 more source

Associations Between Neuromuscular Fatigue, Anxiety, and Peripheral Biomarkers of Neuronal Injury, Inflammation, and Mitochondrial Dysfunction in Treatment‐Naïve Relapsing‐Remitting Multiple Sclerosis

Brain and Behavior, Volume 16, Issue 8, August 2026.
ABSTRACT Objective To investigate whether neuromuscular fatigue and anxiety are associated with a peripheral biological signature involving inflammation, oxidative stress, mitochondrial homeostasis, neurotrophic support, and neuronal/glial injury markers in treatment‐naïve patients with relapsing‐remitting multiple sclerosis (RRMS).
Amanda V. Steckert, Keli Dias Feltrin, Luiz Fernando Silva Rodrigues, Felipe Moreira Liz, Maria Milena Figueiredo Muller, Daniel Paulo Bortoluzzi, Andréia Biolchi Mayer, Luciane Bisognin Ceretta, Tatiana Barichello, Felipe Dal‐Pizzol, Diogo Dominguini   +10 more
wiley   +1 more source

Error Traps in Pediatric Neuromuscular Block

Pediatric Anesthesia, Volume 36, Issue 8, Page 887-898, August 2026.
ABSTRACT Background Neuromuscular blocking agents are essential for safe pediatric anesthesia but remain a frequent source of preventable morbidity when misused, inadequately monitored, or incompletely reversed. Children, particularly neonates and infants, are especially vulnerable to residual neuromuscular block due to developmental pharmacological ...
Gabriel Soares de Sousa, Debra Faulk, Vinicius Caldeira Quintao, Niekoo Abbasian, Hans D. de Boer, Ricardo Vieira Carlos   +5 more
wiley   +1 more source

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, Volume 46, Issue 4, Page 1173-1229, July 2026.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Incidence of postoperative residual neuromuscular blockade: a prospective observational study

Colombian Journal of Anesthesiology
Introduction: The use of non-depolarizing neuromuscular blockers (ND-NMB) is essential in anesthetic management as it improves ventilation conditions, airway management, and surgical conditions.
Diego Luis Vélez-Agudelo, Santiago Andrés Salazar-Cortés, Alex García, Fabián David Casas-Arroyave   +3 more
doaj   +1 more source

Probing Cinnamamides and Benzamides as Anthelmintics: Discovery of Potent Drug‐Like Agents Against Angiostrongylus cantonensis

Chemical Biology &Drug Design, Volume 108, Issue 1, July 2026.
Cynnamoyl benzylpiperazine was identified as drug‐like derivative of cinnarizine with anthelmintic activity against A. cantonensis. In this work, 15 out of 31 derivatives showed improved anthelmintic activity with increased solubility. A SAR study was carried out to determine the molecular features involved in such effect.
Bruna L. Lemes, Mariana A. Siegl‐Breno, Marina T. Varela, Flavia B. Lopes, Mikaelly K. Silva‐Nunes, Thaiane D. Santos, Lucas Fukui‐Silva, Daniel B. Roquini, Vinicius G. Maltarollo, Josué de Moraes, João Paulo S. Fernandes   +10 more
wiley   +1 more source

Neural Organoid Models as a Platform for Studying Disease Mechanisms in Amyotrophic Lateral Sclerosis

Journal of Neurochemistry, Volume 170, Issue 7, July 2026.
Amyotrophic lateral sclerosis (ALS) involves widespread cortical pathology beyond the motor cortex. Human‐induced pluripotent stem cell‐derived neural organoids model cortical tissue in vitro and provide a physiologically relevant platform to study disease mechanisms in ALS.
Kristel N. Eigenhuis, Roberto Montoro Ferrer, R. Jeroen Pasterkamp   +2 more
wiley   +1 more source

Amino acid modulation of the carotid body selectively modulates peripheral chemoreceptor respiratory reflex

The Journal of Physiology, Volume 604, Issue 14, Page 6196-6224, 15 July 2026.
Abstract figure legend When the carotid body (CB) detects low oxygen levels (hypoxia), this leads to: (1) depolarization of the chemosensory cells (glomus cells) within the CB – the resulting increase in intracellular Ca2+ stimulates the exocytotic co‐release of vesicles containing ATP and glutamate; (2) synaptic ATP acts on postsynaptic petrosal ...
Olivia M. S. Gold, Audrys G. Pauza, Igor S. A. Felippe, Xin Shen, Julian F. R. Paton   +4 more
wiley   +1 more source

Neuromuscular blocking agents. Replacement of quaternary ammonium groups in bis-onium compounds by amidinium, guanidinium, thiouronium, sulphonium and sulphoxonium groups

, 1970
The quaternary ammonium groups of suxamethonium have been replaced by amidinium, guanidinium and thiouronium groups. The guanidine compound exhibited competitive neuromuscular activity of a low order of potency; the other compounds were ineffective ...
D F Biggs, M Davis, D G Bamford, P Chaplen   +3 more
core   +1 more source