Results 181 to 190 of about 8,039 (253)

Immunomodulation of the Prostate Tumor Microenvironment Following Inorganic Arsenic Exposure

Journal of Applied Toxicology, EarlyView.
ABSTRACT The tumor microenvironment (TME) influences prostate cancer (PCa) progression through stromal and immune interactions. Adipose‐derived mesenchymal stromal cells (ASCs) modulate immune tone, while inorganic arsenic (iAs), a widespread toxicant, is linked to immune suppression and carcinogenesis.
Joseph J. Shearer, Cosette Rivera‐Cruz, Alexandre M. B. Cavalca, Carlos Eduardo Fonseca‐Alves, Marxa L. Figueiredo   +4 more
wiley   +1 more source

Ivermectin Toxicity in Humans and Animals: Clinical Spectrum, Mechanisms, and Management

Journal of Applied Toxicology, EarlyView.
ABSTRACT Ivermectin is a widely used macrocyclic lactone with established efficacy against a broad range of parasitic infections in humans and animals and a long‐standing reputation for clinical safety. However, increasing evidence indicates that ivermectin can produce clinically relevant toxicity under specific conditions, particularly involving the ...
Serkan Yilmaz, Bayram Göktaş, İlker Ateş, Mustafa Çelik   +3 more
wiley   +1 more source

Derivation and validation of the Pediatric Community‐Acquired Pneumonia Severity (PedCAPS) score: A prospective cohort study

Journal of Hospital Medicine, EarlyView.
Abstract Introduction Community‐acquired pneumonia (CAP) is a frequent and costly cause of pediatric emergency department (ED) visits and hospitalizations. Previous prognostic tools for CAP are limited by small samples, single‐center or retrospective designs, lack of generalizability to ED settings, lack of biomarkers, or limited objective data.
Todd A. Florin, Ron Reeder, Lilliam Ambroggio, Richard M. Ruddy, Samir S. Shah, Allison Cator, Matthew J. Lipshaw, Geoffrey A. Capraro, Laura F. Sartori, Amy Y. Cheng, Leah Tzimenatos, Patrick S. Walsh, Claudia R. Morris, Chris A. Rees, Son H. McLaren, Tamar R. Lubell, Chari D. Larsen, Justin Moher, Eileen J. Klein, Shubhada Hooli, Nathan Kuppermann, Pediatric Emergency Care Applied Research Network (PECARN) PedCAPS Investigators   +21 more
wiley   +1 more source

Prevalence and costs of US pediatric hospitalizations, 2022

Journal of Hospital Medicine, EarlyView.
Abstract Background Pediatric hospitalizations represent an evolving component of US healthcare utilization. The coronavirus disease 2019 (COVID‐19) pandemic hastened rising mental health visits and shrinking rural hospital capacity. Understanding contemporary patterns in pediatric hospitalizations is critical to inform health system planning and ...
Anna J. Lytchakov, Nathan M. Money, Jennifer A. Hoffmann, Todd A. Florin, Kenneth A. Michelson, Sriram Ramgopal   +5 more
wiley   +1 more source

National trends in pediatric sepsis hospitalizations, case mix, and mortality, 2016–2022

Journal of Hospital Medicine, EarlyView.
Abstract Introduction Sepsis is a life‐threatening organ dysfunction caused by a dysregulated host response to infection. We evaluated changes in hospitalizations for children with sepsis between 2016 and 2022 and investigated factors associated with in‐hospital mortality.
Sriram Ramgopal
wiley   +1 more source

Corrigendum to “Learnings from a registry-based cohort study for spinal muscular atrophy disease” [Neuromuscular Disorders, Volume 59, February 2026, 106332] [PDF]

Carla J Jonker, Kelly Plueschke, Kieran C. Breen, Mencia de Lemus Belmonte, Laurent Servais, Patrice Verpillat, Alexandra Pacurariu   +6 more
openalex   +1 more source

Neuromuscular activity, axonal sprouting and stability of conronically enlarged motor units in an animal model of motoneuron disease

, 1999
Siu Lin Tam
openalex   +1 more source

The Role of Ultrasound across the Continuum of Care for Carpal Tunnel Syndrome

Journal of Ultrasound in Medicine, EarlyView.
Carpal tunnel syndrome (CTS) is the most common upper limb entrapment neuropathy and a leading cause of pain, functional impairment, and surgical referral. This article demonstrates the central role of ultrasound (US) across the continuum of CTS care, both for confirming the CTS diagnosis and for guiding treatments ranging from perineural injections to
Christopher M. Jobe, Levon N. Nazarian, Brett J. Kindle, Larry E. Miller, John R. Fowler   +4 more
wiley   +1 more source

PRMT5 Mediates Sepsis‐Associated Lung Injury by Modulating JAK1 Arginine Methylation: A Mechanism Study

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Lung injury is a common complication in critical sepsis. PRMT5 is implicated in endothelial inflammation and lung diseases, but its role in sepsis‐associated lung injury remains unclear. This study collected clinical sepsis samples and detected the mRNA expression of PRMT5.
Bo Wang, Zhen Ge, Fei‐Xiang Chen
wiley   +1 more source

Step‐by‐step insight into gait analysis: A narrative review unlocking knee biomechanics

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Gait analysis offers a powerful tool for clinical and orthopaedic decision‐making. By quantifying spatiotemporal, kinematic and kinetic parameters during walking, it provides a dynamic window into joint function that static imaging cannot capture.
Giovanni Spallone, Letizia Mancini, Arianna Carnevale, Stefano Campi, Alessandro de Sire, Emiliano Schena, Pieter D'Hooghe, Michael T. Hirschmann, Rocco Papalia, Umile Giuseppe Longo   +9 more
wiley   +1 more source