Results 121 to 130 of about 77,782 (191)

Ngn2-Induced Differentiation of the NG108-15 Cell Line Enhances Motor Neuronal Differentiation and Neuromuscular Junction Formation. [PDF]

open access: yesBiomolecules
Meli M   +9 more
europepmc   +1 more source

Nuclear Import Defects Drive Cell Cycle Dysregulation in Neurodegeneration

open access: yesAging Cell, EarlyView.
Overview of Dysregulated Cell Cycle Mechanisms in Neuronal Cells. A nuclear import block drives cell cycle re‐entry from G0, culminating in cell cycle arrest at G1/S. This cell cycle arrest is associated with activation of CKIs from the INK locus (p15, p16, p18, p19) and Cip/Kip (p21, p27) which act on specific CDK/Cyclin complexes.
Jonathan Plessis‐Belair   +3 more
wiley   +1 more source

Increased Frequency of Giant Miniature End-Plate Potentials at the Neuromuscular Junction in Diabetic Rats. [PDF]

open access: yesBiomedicines, 2023
Martínez-Sánchez JE   +8 more
europepmc   +1 more source

ElixirSeeker: A Machine Learning Framework Utilizing Fusion Molecular Fingerprints for the Discovery of Lifespan‐Extending Compounds

open access: yesAging Cell, EarlyView.
ElixirSeeker is a machine learning architecture based on a phenotype‐driven drug discovery approach to screen lifespan‐extending compounds. By integrating molecular fingerprints, ElixirSeeker could maximize feature capture of lifespan‐extending compounds.
Yan Pan   +15 more
wiley   +1 more source

Sleep‐disordered breathing – clinical spectrum

open access: yesAustralian Dental Journal, Volume 69, Issue S1, Page S45-S52, June 2024.
ABSTRACT The clinical spectrum of sleep‐disordered breathing comprises a range of diverse conditions including obstructive sleep apnoea, central sleep apnoea and sleep‐related hypoventilation syndromes. These distinct conditions have specific diagnostic features and are managed differently from one another.
AM Mohammadieh, ASL Chan, PA Cistulli
wiley   +1 more source

Comparison of the effects of occlusal splint and Botox injections on the amount of mouth opening and chronic pain in individuals with temporomandibular disorders: a systematic review and meta‐analysis

open access: yesAustralian Dental Journal, EarlyView.
Abstract Objective This systematic review and meta‐analysis study was carried out to compare the effectiveness of occlusal splint (OS) and Botox (BTX) injections in temporomandibular disorders (TMDs). Material and Methods Irrespective of the starting year, studies were searched for up to 2024 using PubMed, Web of Science, Scopus databases and the ...
Ö İşisağ, H Atasoy, S Yıldız
wiley   +1 more source

Endotypes in Immune Mediated Drug Reactions: Present and Future of Relevant Biomarkers. An EAACI Task Force Report

open access: yesAllergy, EarlyView.
ABSTRACT Drug‐induced immune reactions are an important burden for patients and health systems. They can be classified into immediate‐drug hypersensitivity reactions (IDHRs) and delayed‐DHRs (DDHRs) based on their phenotype. Drugs do not always behave as allergens and need to bind to proteins, forming adducts.
C. Mayorga   +7 more
wiley   +1 more source

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