Results 141 to 150 of about 77,782 (191)

Novel FKBP prolyl isomerase 1A (FKBP12) ligand promotes functional improvement in SOD1G93A amyotrophic lateral sclerosis (ALS) mice

British Journal of Pharmacology, Volume 182, Issue 11, Page 2466-2486, June 2025.
Background and Purpose Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease with limited treatment options. ALS pathogenesis involves intricate processes within motor neurons, characterized by dysregulated Ca2+ influx and buffering in early ALS‐affected motor neurones. This study proposes the modulation of ryanodine receptors (
Laura Moreno‐Martinez, Núria Gaja‐Capdevila, Laura Mosqueira‐Martín, Mireia Herrando‐Grabulosa, Laura Rodriguez‐Gomez, Klaudia Gonzalez‐Imaz, Ana C. Calvo, Maialen Sagartzazu‐Aizpurua, Leticia Moreno‐García, Jose Manuel Fuentes, Abraham Acevedo‐Arozena, Jesús María Aizpurua, José Ignacio Miranda, Adolfo López de Munain, Ainara Vallejo‐Illarramendi, Xavier Navarro, Rosario Osta, Francisco Javier Gil‐Bea   +17 more
wiley   +1 more source

Effects of physical exercise on neuromuscular junction degeneration during ageing: A systematic review. [PDF]

J Orthop Translat
Wang Q, Cui C, Zhang N, Lin W, Chai S, Chow SK, Wong RMY, Hu Y, Law SW, Cheung WH.   +9 more
europepmc   +1 more source

Pathogenic Role of Age‐Associated B Cells in Autoimmune Disorders and Myasthenia Gravis

Clinical and Experimental Neuroimmunology, EarlyView.
ABSTRACT Age‐associated B cell (ABC) is a distinctive B cell subset characterized by CD11c and T‐bet expression that accumulates with aging and in autoimmune conditions. This review summarizes current understanding of ABCs in the immunological function and autoimmune pathogenesis of autoimmune diseases, including myasthenia gravis (MG). ABCs arise when
Hiroyuki Akamine, Akiyuki Uzawa
wiley   +1 more source

Neuromuscular junction dysfunction in Lafora disease.

Dis Model Mech
Shukla M, Chugh D, Ganesh S.
europepmc   +1 more source

Acetylcholine receptor-β inhibition by interleukin-6 in skeletal muscles contributes to modulating neuromuscular junction during aging. [PDF]

Mol Med
Zhao Y, Yan H, Liu K, Ma J, Sun W, Lai H, Li H, Gu J, Huang H.   +8 more
europepmc   +1 more source

NEUROMYODredger: Whole Exome Sequencing for the Diagnosis of Neurodevelopmental and Neuromuscular Disorders in Seven Countries

Clinical Genetics, EarlyView.
NEUROMYODredger‐3billion Megaproject was created to provide a genetic diagnosis for 245 children and adults with neurologic disorders in seven countries for free. With whole exome sequencing on a single patient, we could end the diagnostic odyssey in around 30% of cases.
Edoardo Malfatti, Alexandru Caramizaru, Hane Lee, JiHye Kim, Hussein Shoaito, Alessandra Pennisi, Sarah Souvannanorath, François‐Jérôme Authier, Andreea Dumitrescu, Nagia Fahmy, Rosa Elena Escobar‐Cedillo, Antonio Miranda‐Duarte, Alexandra Berenice Luna‐Angulo, Sonia Nouioua, Ouissem Benchaabi, Meriem Tazir, Sihem Hallal, Peggy Martinez, Claudia Castiglioni, Amelia Dobrescu, Homa Tajsharghi   +20 more
wiley   +1 more source

Basal lamina: A novel pH regulator at the neuromuscular junction. [PDF]

Sci Prog
Durbin R, Renden R.
europepmc   +1 more source

Variability in venom composition of European viper subspecies limits the cross-effectiveness of antivenoms [PDF]

, 2018
Duregotti, Elisa, Giampreti, Andrea, Locatelli, Carlo Alessandro, Lonati, Davide, Pirazzini, Marco, Rossetto, Ornella, Zanetti, Giulia   +6 more
core   +1 more source

Negative effects on oral motor function after submandibular and parotid botulinum neurotoxin A injections for drooling in children with developmental disabilities

Developmental Medicine &Child Neurology, Volume 67, Issue 5, Page 656-664, May 2025.
Graphical representation of the research objective, methodology, key findings, and implications. Plain language summary: https://onlinelibrary.wiley.com/doi/10.1111/dmcn.16171 Abstract Aim To evaluate negative effects on oral motor function after concurrent submandibular and parotid (four‐gland) botulinum neurotoxin A (BoNT‐A) injections as a treatment
Reva M. van Eck, Lynn B. Orriëns, Corinne P. A. Delsing, Frank J. A. van den Hoogen, Corrie E. Erasmus, Karen van Hulst   +5 more
wiley   +1 more source

Sympathetic innervation in skeletal muscle and its role at the neuromuscular junction. [PDF]

J Muscle Res Cell Motil
Rudolf R, Kettelhut IC, Navegantes LCC.
europepmc   +1 more source